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Influencing factors on the suitability of organ-cultured corneas.

Abstract : PURPOSE: To determine the factors related to donor and tissue retrieval, which influence the suitability of organ-cultured corneas for transplantation. PATIENTS AND METHODS: We retrospectively analysed 2596 donor corneas. Polytomic logistic regression analysis was used to assess the influence of various factors (that is, donor age, cause of death, death-to-tissue retrieval time, tissue retrieval-to-reception time, and tissue retrieval method) on the suitability of grafts for transplantation. Positive predictive values (PPVs) were computed. RESULTS: Forty-three percent (1118/2596) of corneas were discarded. The leading cause for discarding corneas was poor endothelial quality (21.5%). Corneas from donors older than 80 years were more likely to be discarded because of endothelial insufficiency (OR=2.37, P=0.001). Longer time between death and tissue retrieval was associated with increased risk of positive serology (OR=1.43, P=0.02). Increased time between tissue retrieval and reception was associated with increased risk of contamination (OR=1.57, P=0.03). PPV increased from 38.5% for corneas retrieved from donors older than 80 years featuring a death-to-tissue retrieval time of more than 6 h and a tissue retrieval-to-reception time of more than 24 h to 64.7% for corneas retrieved from donors younger than 80 years featuring a death-to tissue retrieval time shorter than 6 h and a tissue retrieval-to-reception time shorter than 24 h. CONCLUSION: The percentage of discarded corneas can be reduced by including donors aged 80 years or less, using a time from donor's death to tissue retrieval shorter than 6 h, and a tissue retrieval-to-reception time shorter than 24 h.
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https://www.hal.inserm.fr/inserm-00508120
Contributor : Philippe Saas <>
Submitted on : Monday, August 2, 2010 - 3:19:34 PM
Last modification on : Tuesday, October 27, 2020 - 2:35:49 PM

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Jean-Christophe Gavrilov, Vincent Borderie, Laurent Laroche, Bernard Delbosc. Influencing factors on the suitability of organ-cultured corneas.. Eye (Lond), 2010, 24 (7), pp.1227-33. ⟨10.1038/eye.2009.312⟩. ⟨inserm-00508120⟩

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