Significant Increase in 1-Year Posttransplant Renal Arterial Index Predicts Graft Loss.

Mélanie Terebus Loock 1 Jamal Bamoulid 2, 3 Cécile Courivaud 2, 3 Philippe Manzoni 1 Dominique Simula-Faivre 4 Jean-Marc Chalopin 2, 3, 4 Bruno Kastler 1, 5 Didier Ducloux 2, 3, 4
1 Service de Radiologie A
2 HOTE GREFFON - Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098)
3 Service de Néphrologie et Urologie
4 CICB - Centre d'Investigation Clinique de Besançon
5 I4S - Intervention, innovation, imagerie, ingénierie en santé - UFC
Abstract : BACKGROUND AND OBJECTIVES: Conflicting data have been reported concerning the use of kidney graft arterial resistance index (RI) measured by Doppler to predict death-censored graft loss. We hypothesized that changes in RI values could carry better information than a single measure of RI. DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Four hundred twenty-five renal transplant recipients were included in the study. We tested whether changes in renal arterial resistance index between 4 and 12 months after transplant (DeltaRI(4-->12)) were predictive of graft loss. RESULTS: Neither 4-month nor 1-year RI predicted graft loss. The area under the receiver operating characteristics curve of DeltaRI(4-->12) for graft loss was 0.75. A DeltaRI(4-->12) >/=10% had the best sensitivity and specificity. One year after transplant, 22% of the study population had DeltaRI(4-->12) >/=10%. Fifty-five patients (12.9%) experienced graft loss during follow-up. The annual incidence of graft loss was higher in patients with DeltaRI(4-->12) >/=10% (3.5 versus 1.3%; P = 0.009). In multivariate analysis, patients with DeltaRI(4-->12) >/=10% had an increased risk of graft loss (hazard ratio, 6.21; 95% confidence interval, 1.99 to 22.15; P = 0.002). CONCLUSIONS: A variation in RI >/=10% in the first year after transplant is an independent risk factor for death-censored graft loss in renal transplant recipients.
Type de document :
Article dans une revue
Clinical Journal of the American Society of Nephrology, American Society of Nephrology, 2010, epub ahead of print. 〈10.2215/CJN.01210210〉
Liste complète des métadonnées
http://www.hal.inserm.fr/inserm-00508043
Contributeur : Philippe Saas <>
Soumis le : lundi 2 août 2010 - 14:53:57
Dernière modification le : lundi 9 juillet 2018 - 13:12:02

Lien texte intégral

openaccess

Identifiants

Collections

UNIV-FCOMTE | UMR645

Citation

Mélanie Terebus Loock, Jamal Bamoulid, Cécile Courivaud, Philippe Manzoni, Dominique Simula-Faivre, et al.. Significant Increase in 1-Year Posttransplant Renal Arterial Index Predicts Graft Loss.. Clinical Journal of the American Society of Nephrology, American Society of Nephrology, 2010, epub ahead of print. 〈10.2215/CJN.01210210〉. 〈inserm-00508043〉

Exporter

BibTeX TEI DC DCterms EndNote

Partager

Métriques

Consultations de la notice

78

Contact

support.ccsd.cnrs.fr
hal.support@ccsd.cnrs.fr
Logo CCSD