Skip to Main content Skip to Navigation
Journal articles

Multiple interests in structural models of DARC transmembrane protein.

Abstract : Duffy Antigen Receptor for Chemokines (DARC) is an unusual transmembrane chemokine receptor which (i) binds the two main chemokine families and (ii) does not transduct any signal as it lacks the DRY consensus sequence. It is considered as silent chemokine receptor, a tank useful for chemiotactism. DARC had been particularly studied as a major actor of malaria infection by Plasmodium vivax. It is also implicated in multiple chemokine inflammation, inflammatory diseases, in cancer and might play a role in HIV infection and AIDS. In this review, we focus on the interest to build structural model of DARC to understand more precisely its abilities to bind its physiological ligand CXCL8 and its malaria ligand. We also present innovative development on VHHs able to bind DARC protein. We underline difficulties and limitations of such bioinformatics approaches and highlight the crucial importance of biological data to conduct these kinds of researches.
Document type :
Journal articles
Complete list of metadatas

Cited literature [137 references]  Display  Hide  Download

https://www.hal.inserm.fr/inserm-00506537
Contributor : Alexandre G. de Brevern <>
Submitted on : Wednesday, July 28, 2010 - 10:06:34 AM
Last modification on : Saturday, March 28, 2020 - 2:20:59 AM
Long-term archiving on: : Friday, October 29, 2010 - 10:18:38 AM

File

Smolarek_TCB_2010_preprint.pdf
Files produced by the author(s)

Identifiers

Collections

Citation

Dorota Smolarek, Olivier Bertrand, Marcin Czerwinski, Yves Colin, Catherine Etchebest, et al.. Multiple interests in structural models of DARC transmembrane protein.. Transfusion Clinique et Biologique, Elsevier, 2010, 17 (3), pp.184-96. ⟨10.1016/j.tracli.2010.05.003⟩. ⟨inserm-00506537⟩

Share

Metrics

Record views

355

Files downloads

776