Multiple interests in structural models of DARC transmembrane protein.

Dorota Smolarek 1, 2 Olivier Bertrand 2 Marcin Czerwinski 1 Yves Colin 2 Catherine Etchebest 2 Alexandre De Brevern 2, *
* Auteur correspondant
1 Ludwik Hirszfeld Institute of Immunology and Experimental Therapy
2 DSIMB - Dynamique des Structures et Interactions des Macromolécules Biologiques
Abstract : Duffy Antigen Receptor for Chemokines (DARC) is an unusual transmembrane chemokine receptor which (i) binds the two main chemokine families and (ii) does not transduct any signal as it lacks the DRY consensus sequence. It is considered as silent chemokine receptor, a tank useful for chemiotactism. DARC had been particularly studied as a major actor of malaria infection by Plasmodium vivax. It is also implicated in multiple chemokine inflammation, inflammatory diseases, in cancer and might play a role in HIV infection and AIDS. In this review, we focus on the interest to build structural model of DARC to understand more precisely its abilities to bind its physiological ligand CXCL8 and its malaria ligand. We also present innovative development on VHHs able to bind DARC protein. We underline difficulties and limitations of such bioinformatics approaches and highlight the crucial importance of biological data to conduct these kinds of researches.
Keywords : cancer transmembrane protein comparative modelling bioinformatics protein docking flexible docking camelid VHHs malaria cancer.
Type de document :
Article dans une revue
Transfusion Clinique et Biologique, Elsevier, 2010, 17 (3), pp.184-96. 〈10.1016/j.tracli.2010.05.003〉
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Dorota Smolarek, Olivier Bertrand, Marcin Czerwinski, Yves Colin, Catherine Etchebest, et al.. Multiple interests in structural models of DARC transmembrane protein.. Transfusion Clinique et Biologique, Elsevier, 2010, 17 (3), pp.184-96. 〈10.1016/j.tracli.2010.05.003〉. 〈inserm-00506537〉

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