Blockade of the kinin B1 receptor ameloriates glomerulonephritis. - Archive ouverte HAL Access content directly
Journal Articles Journal of the American Society of Nephrology Year : 2010

Blockade of the kinin B1 receptor ameloriates glomerulonephritis.

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Abstract

Severe inflammation characterizes rapidly progressive glomerulonephritides, and expression of the kinin B1 receptor (B1R) associates with inflammation. Delayed B1R blockade reduces renal inflammation in a model of unilateral ureteral obstruction, but whether B1R modulates the pathophysiology of glomerulonephritides is unknown. Here, we observed an association of B1R protein expression and inflammation, in both glomeruli and the renal interstitium, in biopsies of patients with glomerulonephritides, Henoch-Schönlein purpura nephropathy, and ANCA-associated vasculitis. In the nephrotoxic serum-induced glomerulonephritis model, we observed upregulation of the B1R receptor; treatment with a B1R antagonist beginning 2 weeks after the onset of disease reduced both glomerular and tubular lesions and improved renal function. B1R blockade reduced renal chemokine expression and macrophage accumulation. Collectively, our data demonstrate that blockade of the kinin B1R has significant potential for the treatment of glomerulonephritis.

Dates and versions

inserm-00506236 , version 1 (27-07-2010)

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Julie Klein, Julien Gonzalez, Stéphane Decramer, Flavio Bandin, Eric Neau, et al.. Blockade of the kinin B1 receptor ameloriates glomerulonephritis.. Journal of the American Society of Nephrology, 2010, 21 (7), pp.1157-64. ⟨10.1681/ASN.2009090887⟩. ⟨inserm-00506236⟩
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