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Essential role of TRPC1 channels in cardiomyoblasts hypertrophy mediated by 5-HT2A serotonin receptors.

Abstract : Serotonin (5-HT) participates in the development of cardiac hypertrophy through 5-HT(2A) serotonin receptors. The hypertrophic growth of cardiomyoblasts induced by 5-HT(2A) receptors involves the activation of the Ca(2+) responsive calcineurin/NFAT pathway. However, the mechanism whereby NFAT is activated by 5-HT(2A) receptors remains indeterminate. In this study, we examined whether transient receptor potential canonical (TRPC) channels participate in NFAT activation and hypertrophic response triggered by 5-HT. We demonstrate that TRPC1 expression is upregulated in 5-HT-treated rat cardiomyoblasts whereas TRPC6 is induced in a mouse model of heart hypertrophy. Moreover, TRPC1 knockdown by small interfering RNA inhibits NFAT activation and hypertrophic response mediated by 5-HT(2A) receptors. These findings provide new insights about a mechanistic basis for the activation of the calcineurin/NFAT pathway by 5-HT(2A) receptors and highlight the critical role of TRPC1 in the development of cardiac hypertrophy.
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https://www.hal.inserm.fr/inserm-00505015
Contributor : Marie Francoise Simon <>
Submitted on : Thursday, July 22, 2010 - 11:37:52 AM
Last modification on : Friday, January 10, 2020 - 9:09:09 PM

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Cécile Vindis, Romina d'Angelo, Elodie Mucher, Anne Nègre-Salvayre, Angelo Parini, et al.. Essential role of TRPC1 channels in cardiomyoblasts hypertrophy mediated by 5-HT2A serotonin receptors.. Biochemical and Biophysical Research Communications, Elsevier, 2010, 391 (1), pp.979-83. ⟨10.1016/j.bbrc.2009.12.001⟩. ⟨inserm-00505015⟩

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