FAN (factor associated with neutral sphingomyelinase activation), a moonlighting protein in TNF-R1 signaling. - Archive ouverte HAL Access content directly
Journal Articles Journal of Leukocyte Biology Year : 2010

FAN (factor associated with neutral sphingomyelinase activation), a moonlighting protein in TNF-R1 signaling.

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Abstract

TNF-alpha is a pleiotropic cytokine involved in the regulation of various biological effects, including cell survival and proliferation, cell differentiation, and cell death. Moreover, TNF-alpha triggers proinflammatory responses, essentially through its ability to promote the expression of various proinflammatory genes. Most of the biological effects initiated by TNF-alpha rely on its ability to bind to and activate TNF-R1. As a consequence, molecular complexes are being formed, resulting from the recruitment of multiple adaptor proteins to the intracellular TNF-R1 DD. The adaptor protein FAN constitutively binds to a proximal membrane domain of TNF-R1 called NSD. Herein, the role of FAN in TNF-alpha-induced cell signaling and biological responses is discussed.

Dates and versions

inserm-00504725 , version 1 (21-07-2010)

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Anne Montfort, Pascal G.P. Martin, Thierry Levade, Hervé Benoist, Bruno Ségui. FAN (factor associated with neutral sphingomyelinase activation), a moonlighting protein in TNF-R1 signaling.. Journal of Leukocyte Biology, 2010, 88 (5), epub ahead of print. ⟨10.1189/jlb.0410188⟩. ⟨inserm-00504725⟩
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