Pivotal role of translokin/CEP57 in the unconventional secretion versus nuclear translocation of FGF2.

Abstract : Intracellular trafficking of fibroblast growth factor 2 (FGF2) exhibits two unusual features: (i) it is secreted despite the lack of signal peptide and (ii) it can translocate to the nucleus after interaction with high- and low-affinity receptors on the cell surface, although it does not possess any classical nuclear localization signal. This nuclear translocation constitutes an important part of the response to the growth factor. Previously, we identified Translokin/CEP57, an FGF2 binding partner, as an intracellular mediator of FGF2 trafficking, which is essential for the nuclear translocation of the growth factor. Here, we report the identification of four Translokin partners: sorting nexin 6, Ran-binding protein M and the kinesins KIF3A and KIF3B. These proteins, through their interaction with Translokin, are involved in two exclusive complexes allowing the bidirectional trafficking of FGF2. Thus, Translokin plays a pivotal role in this original mechanism. In addition, we show that FGF2 secretion is regulated by a negative loop, retro-controlled by FGF receptor and involving FGF2 itself.
Type de document :
Article dans une revue
Traffic, Wiley, 2009, 10 (12), pp.1765-72. 〈10.1111/j.1600-0854.2009.00985.x〉
Liste complète des métadonnées

http://www.hal.inserm.fr/inserm-00504711
Contributeur : Marie Francoise Simon <>
Soumis le : mercredi 21 juillet 2010 - 11:15:01
Dernière modification le : jeudi 13 septembre 2018 - 10:26:05

Lien texte intégral

Identifiants

Collections

Citation

Sylvain Meunier, Marina García-Jove Navarro, Carine Bossard, Henrik Laurell, Christian Touriol, et al.. Pivotal role of translokin/CEP57 in the unconventional secretion versus nuclear translocation of FGF2.. Traffic, Wiley, 2009, 10 (12), pp.1765-72. 〈10.1111/j.1600-0854.2009.00985.x〉. 〈inserm-00504711〉

Partager

Métriques

Consultations de la notice

133