Skip to Main content Skip to Navigation
Journal articles

Cystic fibrosis transmembrane conductance regulator (CFTR) regulates the production of osteoprotegerin (OPG) and prostaglandin (PG) E2 in human bone.

Abstract : Bone loss is an important clinical issue in patients with cystic fibrosis (CF). Whether the cystic fibrosis transmembrane conductance regulator (CFTR) plays a direct role in bone cell function is yet unknown. In this study, we provide evidence that inhibition of CFTR-Cl(-) channel function results in a significant decrease of osteoprotegerin (OPG) secretion accompanied with a concomitant increase of prostaglandin (PG) E(2) secretion of primary human osteoblast cultures (n=5). Our data therefore suggest that in bone cells of CF patients, the loss of CFTR activity may result in an increased inflammation-driven bone resorption (through both the reduced OPG and increased PGE(2) production), and thus might contribute to the early bone loss reported in young children with CF.
Complete list of metadatas

https://www.hal.inserm.fr/inserm-00501818
Contributor : Jacky Jacquot <>
Submitted on : Monday, July 12, 2010 - 4:14:40 PM
Last modification on : Friday, March 27, 2020 - 2:37:30 AM
Long-term archiving on: : Thursday, December 1, 2016 - 10:03:43 AM

File

 Restricted access
To satisfy the distribution rights of the publisher, the document is embargoed until : jamais

Please log in to resquest access to the document

Identifiers

Collections

Citation

Louis Le Heron, Christine Guillaume, Frédéric Velard, Julien Braux, Lhousseine Touqui, et al.. Cystic fibrosis transmembrane conductance regulator (CFTR) regulates the production of osteoprotegerin (OPG) and prostaglandin (PG) E2 in human bone.. Journal of Cystic Fibrosis, Elsevier, 2010, 9 (1), pp.69-72. ⟨10.1016/j.jcf.2009.11.005⟩. ⟨inserm-00501818⟩

Share

Metrics

Record views

567