M. Humbert, N. W. Morrell, S. L. Archer, K. R. Stenmark, M. R. Maclean et al., Cellular and molecular pathobiology of pulmonary arterial hypertension, Journal of the American College of Cardiology, vol.43, issue.12, pp.13-24, 2004.
DOI : 10.1016/j.jacc.2004.02.029

E. D. Michelakis, M. R. Wilkins, and M. Rabinovitch, Emerging Concepts and Translational Priorities in Pulmonary Arterial Hypertension, Circulation, vol.118, issue.14, pp.1486-1495, 2008.
DOI : 10.1161/CIRCULATIONAHA.106.673988

D. Caestecker and M. , Serotonin Signaling in Pulmonary Hypertension, Circulation Research, vol.98, issue.10, pp.1229-1231, 2006.
DOI : 10.1161/01.RES.0000225927.04710.33

M. R. Maclean, P. Herve, S. Eddahibi, and S. Adnot, 5-hydroxytryptamine and the pulmonary circulation: receptors, transporters and relevance to pulmonary arterial hypertension, British Journal of Pharmacology, vol.98, issue.Suppl., pp.161-168, 2000.
DOI : 10.1038/sj.bjp.0703570

S. L. Lee, W. W. Wang, and B. L. Fanburg, Association of Tyr phosphorylation of GTPase-activating protein with mitogenic action of serotonin, Am. J. Physiol, vol.272, pp.223-230, 1997.

C. Guilluy, S. Eddahibi, C. Agard, C. Guignabert, M. Izikki et al., RhoA and Rho Kinase Activation in Human Pulmonary Hypertension, American Journal of Respiratory and Critical Care Medicine, vol.179, issue.12, pp.1151-1158, 2009.
DOI : 10.1164/rccm.200805-691OC

Y. Liu, Y. J. Suzuki, R. M. Day, and B. L. Fanburg, Rho Kinase-Induced Nuclear Translocation of ERK1/ERK2 in Smooth Muscle Cell Mitogenesis Caused by Serotonin, Circulation Research, vol.95, issue.6, pp.579-586, 2004.
DOI : 10.1161/01.RES.0000141428.53262.a4

S. L. Lee, A. R. Simon, W. W. Wang, and B. L. Fanburg, O(2) signals 5-HT-induced ERK MAP kinase activation and mitogenesis of smooth muscle cells, Am. J. Physiol. Lung Cell. Mol. Physiol, vol.281, issue.2, pp.646-652, 2001.

S. L. Lee, W. W. Wang, and B. L. Fanburg, Superoxide as an intermediate signal for serotonin-induced mitogenesis. Free Radic, Biol. Med, vol.24, pp.855-858, 1998.

S. Eddahibi, M. Humbert, E. Fadel, B. Raffestin, M. Darmon et al., Serotonin transporter overexpression is responsible for pulmonary artery smooth muscle hyperplasia in primary pulmonary hypertension, Journal of Clinical Investigation, vol.108, issue.8, pp.1141-1150, 2001.
DOI : 10.1172/JCI200112805

C. Guignabert, B. Raffestin, R. Benferhat, W. Raoul, P. Zadigue et al., Serotonin Transporter Inhibition Prevents and Reverses Monocrotaline-Induced Pulmonary Hypertension in Rats, Circulation, vol.111, issue.21, pp.2812-2819, 2005.
DOI : 10.1161/CIRCULATIONAHA.104.524926
URL : https://hal.archives-ouvertes.fr/inserm-00499643

E. Marcos, S. Adnot, M. H. Pham, A. Nosjean, B. Raffestin et al., Serotonin Transporter Inhibitors Protect against Hypoxic Pulmonary Hypertension, American Journal of Respiratory and Critical Care Medicine, vol.168, issue.4, pp.487-493, 2003.
DOI : 10.1164/rccm.200210-1212OC

C. Guignabert, M. Izikki, L. I. Tu, Z. Li, P. Zadigue et al., Transgenic Mice Overexpressing the 5-Hydroxytryptamine Transporter Gene in Smooth Muscle Develop Pulmonary Hypertension, Circulation Research, vol.98, issue.10, pp.1323-1330, 2006.
DOI : 10.1161/01.RES.0000222546.45372.a0
URL : https://hal.archives-ouvertes.fr/inserm-00499636

S. Bonnet, E. D. Michelakis, C. J. Porter, M. A. Andrade-navarro, B. Thebaud et al., An Abnormal Mitochondrial-Hypoxia Inducible Factor-1??-Kv Channel Pathway Disrupts Oxygen Sensing and Triggers Pulmonary Arterial Hypertension in Fawn Hooded Rats: Similarities to Human Pulmonary Arterial Hypertension, Circulation, vol.113, issue.22, pp.2630-2641, 2006.
DOI : 10.1161/CIRCULATIONAHA.105.609008

X. J. Yuan, Voltage-Gated K+ Currents Regulate Resting Membrane Potential and [Ca2+]i in Pulmonary Arterial Myocytes, Circulation Research, vol.77, issue.2, pp.370-378, 1995.
DOI : 10.1161/01.RES.77.2.370

X. J. Yuan, J. Wang, M. Juhaszova, S. P. Gaine, R. et al., Attenuated K+ channel gene transcription in primary pulmonary hypertension, The Lancet, vol.351, issue.9104, pp.726-727, 1998.
DOI : 10.1016/S0140-6736(05)78495-6

S. L. Archer, M. Gomberg-maitland, M. L. Maitland, S. Rich, J. G. Garcia et al., Mitochondrial metabolism, redox signaling, and fusion: a mitochondria-ROS-HIF-1??-Kv1.5 O2-sensing pathway at the intersection of pulmonary hypertension and cancer, AJP: Heart and Circulatory Physiology, vol.294, issue.2, pp.570-578, 2008.
DOI : 10.1152/ajpheart.01324.2007

A. M. Evans, O. N. Osipenko, and A. M. Gurney, Properties of a novel K+ current that is active at resting potential in rabbit pulmonary artery smooth muscle cells., The Journal of Physiology, vol.496, issue.2, 1996.
DOI : 10.1113/jphysiol.1996.sp021694

J. M. Post, C. H. Gelband, and J. R. Hume, [Ca2+]i Inhibition of K+ Channels in Canine Pulmonary Artery : Novel Mechanism for Hypoxia-Induced Membrane Depolarization, Circulation Research, vol.77, issue.1, pp.131-139, 1995.
DOI : 10.1161/01.RES.77.1.131

M. S. Mcmurtry, S. L. Archer, D. C. Altieri, S. Bonnet, A. Haromy et al., Gene therapy targeting survivin selectively induces pulmonary vascular apoptosis and reverses pulmonary arterial hypertension, Journal of Clinical Investigation, vol.115, issue.6, pp.1479-1491, 2005.
DOI : 10.1172/JCI23203

M. S. Mcmurtry, S. Bonnet, X. Wu, J. R. Dyck, A. Haromy et al., Dichloroacetate Prevents and Reverses Pulmonary Hypertension by Inducing Pulmonary Artery Smooth Muscle Cell Apoptosis, Circulation Research, vol.95, issue.8, pp.830-840, 2004.
DOI : 10.1161/01.RES.0000145360.16770.9f

H. L. Reeve, E. Michelakis, D. P. Nelson, E. K. Weir, and S. L. Archer, Alterations in a redox oxygen sensing mechanism in chronic hypoxia, J. Appl. Physiol, vol.90, pp.2249-2256, 2001.

C. V. Remillard, D. D. Tigno, O. Platoshyn, E. D. Burg, E. E. Brevnova et al., Function of Kv1.5 channels and genetic variations of KCNA5 in patients with idiopathic pulmonary arterial hypertension, AJP: Cell Physiology, vol.292, issue.5, pp.1837-1853, 2007.
DOI : 10.1152/ajpcell.00405.2006

K. A. Young, C. Ivester, J. West, M. Carr, and D. M. Rodman, BMP signaling controls PASMC KV channel expression in vitro and in vivo, AJP: Lung Cellular and Molecular Physiology, vol.290, issue.5, pp.841-848, 2006.
DOI : 10.1152/ajplung.00158.2005

J. X. Yuan, A. M. Aldinger, M. Juhaszova, J. Wang, J. V. Conte et al., Dysfunctional Voltage-Gated K+ Channels in Pulmonary Artery Smooth Muscle Cells of Patients With Primary Pulmonary Hypertension, Circulation, vol.98, issue.14, pp.1400-1406, 1998.
DOI : 10.1161/01.CIR.98.14.1400

Y. Yu, O. Platoshyn, J. Zhang, S. Krick, Y. Zhao et al., c-Jun Decreases Voltage-Gated K+ Channel Activity in Pulmonary Artery Smooth Muscle Cells, Jun decreases voltagegated K() channel activity in pulmonary artery smooth muscle cells, pp.1557-1563, 2001.
DOI : 10.1161/hc3801.095662

A. Cogolludo, L. Moreno, F. Lodi, G. Frazziano, L. Cobeno et al., Serotonin Inhibits Voltage-Gated K+ Currents in Pulmonary Artery Smooth Muscle Cells: Role of 5-HT2A Receptors, Caveolin-1, and KV1.5 Channel Internalization, Circulation Research, vol.98, issue.7, pp.931-938, 2006.
DOI : 10.1161/01.RES.0000216858.04599.e1

E. D. Michelakis, M. S. Mcmurtry, X. C. Wu, J. R. Dyck, R. Moudgil et al., Dichloroacetate, a Metabolic Modulator, Prevents and Reverses Chronic Hypoxic Pulmonary Hypertension in Rats: Role of Increased Expression and Activity of Voltage-Gated Potassium Channels, Circulation, vol.105, issue.2, pp.244-250, 2002.
DOI : 10.1161/hc0202.101974

J. W. Kim, I. Tchernyshyov, G. L. Semenza, and C. V. Dang, HIF-1-mediated expression of pyruvate dehydrogenase kinase: A metabolic switch required for cellular adaptation to hypoxia, Cell Metabolism, vol.3, issue.3, pp.177-185, 2006.
DOI : 10.1016/j.cmet.2006.02.002

I. Papandreou, R. A. Cairns, L. Fontana, A. L. Lim, and N. C. Denko, HIF-1 mediates adaptation to hypoxia by actively downregulating mitochondrial oxygen consumption, Cell Metabolism, vol.3, issue.3, pp.187-197, 2006.
DOI : 10.1016/j.cmet.2006.01.012

E. D. Michelakis, L. Webster, and J. R. Mackey, Dichloroacetate (DCA) as a potential metabolic-targeting therapy for cancer, British Journal of Cancer, vol.284, issue.7, pp.989-994, 2008.
DOI : 10.1038/35048073

J. Y. Wong, G. S. Huggins, M. Debidda, N. C. Munshi, D. Vivo et al., Dichloroacetate induces apoptosis in endometrial cancer cells, Gynecologic Oncology, vol.109, issue.3, pp.394-402, 2008.
DOI : 10.1016/j.ygyno.2008.01.038

S. Bonnet, S. L. Archer, J. Allalunis-turner, A. Haromy, C. Beaulieu et al., A Mitochondria-K+ Channel Axis Is Suppressed in Cancer and Its Normalization Promotes Apoptosis and Inhibits Cancer Growth, Cancer Cell, vol.11, issue.1, pp.37-51, 2007.
DOI : 10.1016/j.ccr.2006.10.020

R. Moudgil, E. D. Michelakis, and S. L. Archer, Channels in Determining Pulmonary Vascular Tone, Oxygen Sensing, Cell Proliferation, and Apoptosis: Implications in Hypoxic Pulmonary Vasoconstriction and Pulmonary Arterial Hypertension, Microcirculation, vol.13, issue.8, pp.615-632, 2006.
DOI : 10.1080/10739680600930222

S. Eddahibi, N. Hanoun, L. Lanfumey, K. P. Lesch, B. Raffestin et al., Attenuated hypoxic pulmonary hypertension in mice lacking the 5-hydroxytryptamine transporter gene, Journal of Clinical Investigation, vol.105, issue.11, pp.1555-1562, 2000.
DOI : 10.1172/JCI8678

S. Eddahibi, C. Guignabert, A. M. Barlier-mur, L. Dewachter, E. Fadel et al., Cross Talk Between Endothelial and Smooth Muscle Cells in Pulmonary Hypertension: Critical Role for Serotonin-Induced Smooth Muscle Hyperplasia, Circulation, vol.113, issue.15, pp.1857-1864, 2006.
DOI : 10.1161/CIRCULATIONAHA.105.591321

S. Bonnet, G. Rochefort, G. Sutendra, S. L. Archer, A. Haromy et al., The nuclear factor of activated T cells in pulmonary arterial hypertension can be therapeutically targeted, Proceedings of the National Academy of Sciences, vol.104, issue.27, pp.11418-11423, 2007.
DOI : 10.1073/pnas.0610467104

M. Izikki, C. Guignabert, E. Fadel, M. Humbert, L. Tu et al., Endothelial-derived FGF2 contributes to the progression of pulmonary hypertension in humans and rodents, Journal of Clinical Investigation, vol.119, issue.3, pp.512-523, 2009.
DOI : 10.1172/JCI35070
URL : https://hal.archives-ouvertes.fr/inserm-00499635

S. L. Merklinger, P. L. Jones, E. C. Martinez, and M. Rabinovitch, Epidermal Growth Factor Receptor Blockade Mediates Smooth Muscle Cell Apoptosis and Improves Survival in Rats With Pulmonary Hypertension, Circulation, vol.112, issue.3, pp.423-431, 2005.
DOI : 10.1161/CIRCULATIONAHA.105.540542

R. T. Schermuly, E. Dony, H. A. Ghofrani, S. Pullamsetti, R. Savai et al., Reversal of experimental pulmonary hypertension by PDGF inhibition, Journal of Clinical Investigation, vol.115, issue.10, pp.2811-2821, 2005.
DOI : 10.1172/JCI24838

F. G. Zhai, X. H. Zhang, W. , and H. L. , Fluoxetine protects against monocrotaline-induced pulmonary arterial hypertension is relevant to induction of apoptosis and up-regulation of Kv1.5 channels in rats. [E-pub ahead of print, Clin. Exp. Pharmacol. Physiol, 2009.

N. F. Voelkel, C. Cool, S. D. Lee, L. Wright, M. W. Geraci et al., Primary Pulmonary Hypertension Between Inflammation and Cancer, Chest, vol.114, issue.3, pp.225-230, 1998.
DOI : 10.1378/chest.114.3_Supplement.225S

E. Bush, J. Fielitz, L. Melvin, M. Martinez-arnold, T. A. Mckinsey et al., A small molecular activator of cardiac hypertrophy uncovered in a chemical screen for modifiers of the calcineurin signaling pathway, Proceedings of the National Academy of Sciences, vol.101, issue.9, pp.2870-2875, 2004.
DOI : 10.1073/pnas.0308723101

A. Walczak-drzewiecka, M. Ratajewski, W. Wagner, and J. Dastych, HIF-1?? Is Up-Regulated in Activated Mast Cells by a Process That Involves Calcineurin and NFAT, The Journal of Immunology, vol.181, issue.3, pp.1665-1672, 2008.
DOI : 10.4049/jimmunol.181.3.1665

F. Macian, NFAT proteins: key regulators of T-cell development and function, Nature Reviews Immunology, vol.7, issue.6, pp.472-484, 2005.
DOI : 10.1073/pnas.0402803101