M. Kaufmann, G. Von-minckwitz, and A. Rody, Preoperative (neoadjuvant) systemic treatment of breast cancer, The Breast, vol.14, issue.6, pp.576-81, 2005.
DOI : 10.1016/j.breast.2005.08.010

L. Michaelis and M. Ratain, Measuring response in a post-RECIST world: from black and white to shades of grey, Nature Reviews Cancer, vol.23, issue.5, pp.409-423, 2006.
DOI : 10.1038/nrc1883

P. Bertheau, F. Lerebours, N. Mounier, A. De-roquancourt, M. Espie et al., Prognostic significance of a combined clinicopathologic score for response to primary systemic therapy in locally advanced breast cancer, Oncology Reports, vol.14, pp.513-533, 2005.
DOI : 10.3892/or.14.2.513

J. Brown and L. Attardi, The role of apoptosis in cancer development and treatment response, Nat Rev Cancer, vol.5, pp.231-238, 2005.

M. Collado, M. Blasco, and M. Serrano, Cellular Senescence in Cancer and Aging, Cell, vol.130, issue.2, pp.223-256, 2007.
DOI : 10.1016/j.cell.2007.07.003

Y. Deng, S. Chan, and S. Chang, Telomere dysfunction and tumour suppression: the senescence connection, Nature Reviews Cancer, vol.21, issue.6, pp.450-458, 2008.
DOI : 10.1038/nrc2393

A. Di-fagagna and F. , Living on a break: cellular senescence as a DNA-damage response, Nature Reviews Cancer, vol.67, issue.7, pp.512-534, 2008.
DOI : 10.1038/nrc2440

K. Cichowski and W. Hahn, Unexpected Pieces to the Senescence Puzzle, Cell, vol.133, issue.6, pp.958-61, 2008.
DOI : 10.1016/j.cell.2008.05.027

J. Royds and B. Iacopetta, p53 and disease: when the guardian angel fails, Cell Death and Differentiation, vol.280, issue.6, pp.1017-1043, 2006.
DOI : 10.1038/sj.cdd.4401913

G. Dimri, X. Lee, G. Basile, M. Acosta, G. Scott et al., A biomarker that identifies senescent human cells in culture and in aging skin in vivo., Proceedings of the National Academy of Sciences, vol.92, issue.20, pp.9363-9370, 1995.
DOI : 10.1073/pnas.92.20.9363

I. Roninson, Tumor cell senescence in cancer treatment, Cancer Res, vol.63, pp.2705-2720, 2003.

Q. Chen, J. Liu, and J. Merrett, Apoptosis or senescence-like growth arrest: influence of cell-cycle position, p53, p21 and bax in H2O2 response of normal human fibroblasts, Biochemical Journal, vol.347, issue.2, pp.543-51, 2000.
DOI : 10.1042/bj3470543

D. Hattangadi, G. Demasters, T. Walker, K. Jones, X. Di et al., Influence of p53 and caspase 3 activity on cell death and senescence in response to methotrexate in the breast tumor cell, Biochemical Pharmacology, vol.68, issue.9, pp.1699-708, 2004.
DOI : 10.1016/j.bcp.2004.06.033

J. Leal, J. Fominaya, A. Cascon, M. Guijarro, C. Blanco-aparicio et al., Cellular senescence bypass screen identifies new putative tumor suppressor genes, Oncogene, vol.16, issue.14, pp.1961-70, 2008.
DOI : 10.1038/sj.emboj.7600656

S. Courtois-cox, S. Jones, and K. Cichowski, Many roads lead to oncogene-induced senescence, Oncogene, vol.14, issue.20, pp.2801-2810, 2008.
DOI : 10.1016/j.molcel.2007.05.034

M. Collado, J. Gil, A. Efeyan, C. Guerra, A. Schuhmacher et al., Tumour biology: Senescence in premalignant tumours, Nature, vol.436, issue.7051, p.642, 2005.
DOI : 10.1038/436642a

H. Zhang, Molecular signaling and genetic pathways of senescence: Its role in tumorigenesis and aging, Journal of Cellular Physiology, vol.15, issue.3, pp.567-574, 2007.
DOI : 10.1002/jcp.20919

R. Te-poele, A. Okorokov, L. Jardine, J. Cummings, and S. Joel, DNA damage is able to induce senescence in tumor cells in vitro and in vivo, Cancer Res, vol.62, pp.1876-83, 2002.

L. Elmore, C. Rehder, X. Di, P. Mcchesney, C. Jackson-cook et al., Adriamycin-induced Senescence in Breast Tumor Cells Involves Functional p53 and Telomere Dysfunction, Journal of Biological Chemistry, vol.277, issue.38, pp.35509-35524, 2002.
DOI : 10.1074/jbc.M205477200

P. Bertheau, F. Plassa, M. Espie, E. Turpin, A. De-roquancourt et al., Effect of mutated TP53 on response of advanced breast cancers to high-dose chemotherapy, The Lancet, vol.360, issue.9336, pp.852-856, 2002.
DOI : 10.1016/S0140-6736(02)09969-5

J. Che and Y. Beuzard, Exquisite sensitivity of TP53 mutant and basal breast cancers to a dose-dense epirubicin-cyclophosphamide regimen, PLo S Med, vol.4, p.90, 2007.
URL : https://hal.archives-ouvertes.fr/inserm-00700961

E. Marangoni, A. Vincent-salomon, N. Auger, A. Degeorges, F. Assayag et al., A New Model of Patient Tumor-Derived Breast Cancer Xenografts for Preclinical Assays, Clinical Cancer Research, vol.13, issue.13, pp.3989-98, 2007.
DOI : 10.1158/1078-0432.CCR-07-0078

J. Flaman, T. Frebourg, V. Moreau, F. Charbonnier, C. Martin et al., A simple p53 functional assay for screening cell lines, blood, and tumors., Proceedings of the National Academy of Sciences, vol.92, issue.9, pp.3963-3970, 1995.
DOI : 10.1073/pnas.92.9.3963

T. Nielsen, F. Hsu, K. Jensen, M. Cheang, G. Karaca et al., Immunohistochemical and Clinical Characterization of the Basal-Like Subtype of Invasive Breast Carcinoma, Clinical Cancer Research, vol.10, issue.16, pp.5367-74, 2004.
DOI : 10.1158/1078-0432.CCR-04-0220

M. Nitta, O. Kobayashi, S. Honda, T. Hirota, S. Kuninaka et al., Spindle checkpoint function is required for mitotic catastrophe induced by DNA-damaging agents, Oncogene, vol.23, issue.39, pp.6548-58, 2004.
DOI : 10.1038/sj.onc.1207873

M. Castedo, J. Perfettini, T. Roumier, K. Yakushijin, D. Horne et al., The cell cycle checkpoint kinase Chk2 is a negative regulator of mitotic catastrophe, Oncogene, vol.23, issue.25, pp.4353-61, 2004.
DOI : 10.1038/sj.onc.1207573

C. Moreno, L. Matyunina, E. Dickerson, N. Schubert, N. Bowen et al., Evidence that p53-Mediated Cell-Cycle-Arrest Inhibits Chemotherapeutic Treatment of Ovarian Carcinomas, PLoS ONE, vol.7, issue.5, p.441, 2007.
DOI : 10.1371/journal.pone.0000441.s002

R. Middelburg, R. De-haas, H. Dekker, R. Kerkhoven, P. Pohlmann et al., Induction of p53 Up-Regulated Modulator of Apoptosis Messenger RNA by Chemotherapeutic Treatment of Locally Advanced Breast Cancer, Clinical Cancer Research, vol.11, issue.5, pp.1863-1869, 2005.
DOI : 10.1158/1078-0432.CCR-04-1372

M. Varna, H. Soliman, J. Feugeas, E. Turpin, D. Chapelin et al., Changes in allelic imbalances in locally advanced breast cancers after chemotherapy, British Journal of Cancer, vol.18, issue.8, pp.1157-1164, 2007.
DOI : 10.1038/sj.onc.1200812