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Dependence receptors: mechanisms of an announced death.

Chantal Thibert 1, * Joanna Fombonne 1 
* Corresponding author
Abstract : Dependence receptors form a family of functionally related receptors which are all able to induce two completely opposite intracellular signals depending on the availability of their ligand. Indeed, in its presence, they mediate a positive, classical signal transduction of survival, differentiation or migration but without it, they trigger a negative signal which leads to cell death. The molecular mechanisms involved in triggering cell death in the absence of ligand are starting to be unravelled: dependence receptors are recruited at well-defined domains at the plasma membrane, they trigger cell death through a monomeric form, they are cleaved by caspases and they recruit a caspase activating complex.
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Submitted on : Monday, March 19, 2012 - 9:55:21 AM
Last modification on : Wednesday, February 24, 2021 - 11:06:03 AM
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  • HAL Id : inserm-00498255, version 1
  • PUBMED : 20495383



Chantal Thibert, Joanna Fombonne. Dependence receptors: mechanisms of an announced death.. Cell Cycle, Taylor & Francis, 2010, 9 (11), pp.2085-91. ⟨inserm-00498255⟩



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