Dependence receptors: mechanisms of an announced death.

Abstract : Dependence receptors form a family of functionally related receptors which are all able to induce two completely opposite intracellular signals depending on the availability of their ligand. Indeed, in its presence, they mediate a positive, classical signal transduction of survival, differentiation or migration but without it, they trigger a negative signal which leads to cell death. The molecular mechanisms involved in triggering cell death in the absence of ligand are starting to be unravelled: dependence receptors are recruited at well-defined domains at the plasma membrane, they trigger cell death through a monomeric form, they are cleaved by caspases and they recruit a caspase activating complex.
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Cell Cycle, Taylor & Francis, 2010, 9 (11), pp.2085-91
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Chantal Thibert, Joanna Fombonne. Dependence receptors: mechanisms of an announced death.. Cell Cycle, Taylor & Francis, 2010, 9 (11), pp.2085-91. 〈inserm-00498255〉

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