Synchrotron-based intra-venous K-edge digital subtraction angiography in a pig model: a feasibility study. - Archive ouverte HAL Access content directly
Journal Articles European Journal of Radiology Year : 2010

Synchrotron-based intra-venous K-edge digital subtraction angiography in a pig model: a feasibility study.

(1, 2, 3) , (4) , (5) , (1) , (1, 6) , (7) , (8) , (5) , (5) , (5) , (5) , (3) , (1)
1
2
3
4
5
6
7
8

Abstract

BACKGROUND: K-edge digital subtraction angiography (KEDSA) combined with the tunability of synchrotron beam yields an imaging technique that is highly sensitive to low concentrations of contrast agents. Thus, contrast agent can be administered intravenously, obviating the need for insertion of a guided catheter to deliver a bolus of contrast agent close to the target tissue. With the high-resolution detectors used at synchrotron facilities, images can be acquired at high spatial resolution. Thus, the KEDSA appears particularly suited for studies of neurovascular pathology in animal models, where the vascular diameters are significantly smaller than in human patients. MATERIALS AND METHODS: This feasibility study was designed to test the suitability of KEDSA after intravenous injection of iodine-based contrast agent for use in a pig model. Four adult male pigs were used for our experiments. Neurovascular angiographic images were acquired using KEDSA with a solid state Germanium (Ge) detector at the European Synchrotron Radiation Facility (ESRF) in Grenoble, France. RESULTS: After intravenous injection of 0.9 ml/kg iodinated contrast agent (Xenetix), the peak iodine concentrations in the internal carotid and middle cerebral arteries reached 35 mg/ml. KEDSA images in radiography mode allowed the visualization of intracranial arteries of less than 1.5mm diameter.
Embargoed file
Embargoed file
Ne sera jamais visible
Loading...

Dates and versions

inserm-00498248 , version 1 (12-09-2011)

Identifiers

Cite

Elisabeth Schültke, Stefan Fiedler, Christian Nemoz, Lissa Ogieglo, Michael E. Kelly, et al.. Synchrotron-based intra-venous K-edge digital subtraction angiography in a pig model: a feasibility study.. European Journal of Radiology, 2010, 73 (3), pp.677-81. ⟨10.1016/j.ejrad.2009.01.019⟩. ⟨inserm-00498248⟩

Collections

INSERM UGA U836
124 View
0 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More