TLR5 signaling stimulates the innate production of IL-17 and IL-22 by CD3(neg)CD127+ immune cells in spleen and mucosa. - Archive ouverte HAL Access content directly
Journal Articles Journal of Immunology Year : 2010

TLR5 signaling stimulates the innate production of IL-17 and IL-22 by CD3(neg)CD127+ immune cells in spleen and mucosa.

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Laure Janot
  • Function : Author
  • PersonId : 760242
  • IdRef : 137147686
Arndt Benecke
Bernhard Ryffel
  • Function : Author
  • PersonId : 841831

Abstract

In adaptive immunity, Th17 lymphocytes produce the IL-17 and IL-22 cytokines that stimulate mucosal antimicrobial defenses and tissue repair. In this study, we observed that the TLR5 agonist flagellin induced swift and transient transcription of genes encoding IL-17 and IL-22 in lymphoid, gut, and lung tissues. This innate response also temporarily enhanced the expression of genes associated with the antimicrobial Th17 signature. The source of the Th17-related cytokines was identified as novel populations of CD3(neg)CD127(+) immune cells among which CD4-expressing cells resembling lymphoid tissue inducer cells. We also demonstrated that dendritic cells are essential for expression of Th17-related cytokines and so for stimulation of innate cells. These data define that TLR-induced activation of CD3(neg)CD127(+) cells and production of Th17-related cytokines may be crucial for the early defenses against pathogen invasion of host tissues.
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Dates and versions

inserm-00495564 , version 1 (22-12-2010)

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Cite

Laurye van Maele, Christophe Carnoy, Delphine Cayet, Pascal Songhet, Laure Dumoutier, et al.. TLR5 signaling stimulates the innate production of IL-17 and IL-22 by CD3(neg)CD127+ immune cells in spleen and mucosa.. Journal of Immunology, 2010, 185 (2), pp.1177-85. ⟨10.4049/jimmunol.1000115⟩. ⟨inserm-00495564⟩
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