Skip to Main content Skip to Navigation
Journal articles

TLR5 signaling stimulates the innate production of IL-17 and IL-22 by CD3(neg)CD127+ immune cells in spleen and mucosa.

Abstract : In adaptive immunity, Th17 lymphocytes produce the IL-17 and IL-22 cytokines that stimulate mucosal antimicrobial defenses and tissue repair. In this study, we observed that the TLR5 agonist flagellin induced swift and transient transcription of genes encoding IL-17 and IL-22 in lymphoid, gut, and lung tissues. This innate response also temporarily enhanced the expression of genes associated with the antimicrobial Th17 signature. The source of the Th17-related cytokines was identified as novel populations of CD3(neg)CD127(+) immune cells among which CD4-expressing cells resembling lymphoid tissue inducer cells. We also demonstrated that dendritic cells are essential for expression of Th17-related cytokines and so for stimulation of innate cells. These data define that TLR-induced activation of CD3(neg)CD127(+) cells and production of Th17-related cytokines may be crucial for the early defenses against pathogen invasion of host tissues.
Complete list of metadatas

https://www.hal.inserm.fr/inserm-00495564
Contributor : Jean-Claude Sirard <>
Submitted on : Wednesday, December 22, 2010 - 9:16:11 AM
Last modification on : Wednesday, September 30, 2020 - 4:28:02 PM
Long-term archiving on: : Wednesday, March 23, 2011 - 2:24:24 AM

Identifiers

Citation

Laurye van Maele, Christophe Carnoy, Delphine Cayet, Pascal Songhet, Laure Dumoutier, et al.. TLR5 signaling stimulates the innate production of IL-17 and IL-22 by CD3(neg)CD127+ immune cells in spleen and mucosa.. Journal of Immunology, Publisher : Baltimore : Williams & Wilkins, c1950-. Latest Publisher : Bethesda, MD : American Association of Immunologists, 2010, 185 (2), pp.1177-85. ⟨10.4049/jimmunol.1000115⟩. ⟨inserm-00495564⟩

Share

Metrics

Record views

516

Files downloads

2882