Skip to Main content Skip to Navigation
Journal articles

Motor neuron-immune interactions: the vicious circle of ALS.

Abstract : Because microglial cells, the resident macrophages of the CNS, react to any lesion of the nervous system, they have for long been regarded as potential players in the pathogenesis of several neurodegenerative disorders including amyotrophic lateral sclerosis, the most common motor neuron disease in the adult. In recent years, this microglial reaction to motor neuron injury, in particular, and the innate immune response, in general, has been implicated in the progression of the disease, in mouse models of ALS. The mechanisms by which microglial cells influence motor neuron death in ALS are still largely unknown. Microglial activation increases over the course of the disease and is associated with an alteration in the production of toxic factors and also neurotrophic factors. Adding to the microglial/macrophage response to motor neuron degeneration, the adaptive immune system can likewise influence the disease process. Exploring these motor neuron-immune interactions could lead to a better understanding in the physiopathology of ALS to find new pathways to slow down motor neuron degeneration.
Document type :
Journal articles
Complete list of metadata

Cited literature [216 references]  Display  Hide  Download
Contributor : Severine Boillee <>
Submitted on : Thursday, June 17, 2010 - 6:13:21 PM
Last modification on : Thursday, December 10, 2020 - 12:35:34 PM
Long-term archiving on: : Monday, September 20, 2010 - 5:36:34 PM


Files produced by the author(s)



Ana Barbeito, Pinar Mesci, Séverine Boillée. Motor neuron-immune interactions: the vicious circle of ALS.. Journal of Neural Transmission, Springer Verlag, 2010, 117 (8), pp.981-1000. ⟨10.1007/s00702-010-0429-0⟩. ⟨inserm-00493049⟩



Record views


Files downloads