A. Abella, P. Dubus, M. Malumbres, S. Rane, H. Kiyokawa et al., Cdk4 promotes adipogenesis through PPAR?? activation, Cell Metabolism, vol.2, issue.4, pp.239-249, 2005.
DOI : 10.1016/j.cmet.2005.09.003
URL : http://doi.org/10.1016/j.cmet.2005.09.003

J. Annicotte, E. Blanchet, C. Chavey, I. Iankova, S. Costes et al., The CDK4???pRB???E2F1 pathway controls insulin secretion, Nature Cell Biology, vol.283, issue.8, pp.1017-1023, 2009.
DOI : 10.1016/j.cmet.2005.09.003
URL : https://hal.archives-ouvertes.fr/inserm-00418907

A. Barthel, S. Okino, J. Liao, K. Nakatani, J. Li et al., Regulation of GLUT1 Gene Transcription by the Serine/Threonine Kinase Akt1, Journal of Biological Chemistry, vol.274, issue.29, pp.20281-20286, 1999.
DOI : 10.1074/jbc.274.29.20281

D. Bauer, G. Hatzivassiliou, F. Zhao, C. Andreadis, and C. Thompson, ATP citrate lyase is an important component of cell growth and transformation, Oncogene, vol.268, issue.41, pp.6314-6322, 2005.
DOI : 10.1038/sj.onc.1208773

D. Berwick, I. Hers, K. Heesom, S. Moule, and J. Tavare, The Identification of ATP-citrate Lyase as a Protein Kinase B (Akt) Substrate in Primary Adipocytes, Journal of Biological Chemistry, vol.277, issue.37, pp.33895-33900, 2002.
DOI : 10.1074/jbc.M204681200

A. Black, J. Black, and J. Azizkhan-clifford, Sp1 and kr??ppel-like factor family of transcription factors in cell growth regulation and cancer, Journal of Cellular Physiology, vol.21, issue.2, pp.143-160, 2001.
DOI : 10.1002/jcp.1111

H. Cam, E. Balciunaite, A. Blais, A. Spektor, R. Scarpulla et al., A Common Set of Gene Regulatory Networks Links Metabolism and Growth Inhibition, Molecular Cell, vol.16, issue.3, pp.399-411, 2004.
DOI : 10.1016/j.molcel.2004.09.037

H. Chen, S. Tsai, and G. Leone, Emerging roles of E2Fs in cancer: an exit from cell cycle control, Nature Reviews Cancer, vol.94, issue.11, pp.785-797, 2009.
DOI : 10.1038/nrc2696

F. Chiaradonna, E. Sacco, R. Manzoni, M. Giorgio, M. Vanoni et al., Ras-dependent carbon metabolism and transformation in mouse fibroblasts, Oncogene, vol.12, issue.39, pp.5391-5404, 2006.
DOI : 10.1038/sj.onc.1209528

N. Dali-youcef, C. Mataki, A. Coste, N. Messaddeq, S. Giroud et al., Adipose tissue-specific inactivation of the retinoblastoma protein protects against diabesity because of increased energy expenditure, Proceedings of the National Academy of Sciences, vol.104, issue.25, pp.10703-10708, 2007.
DOI : 10.1073/pnas.0611568104
URL : https://hal.archives-ouvertes.fr/hal-00189403

S. Daniel and K. Kim, Sp1 Mediates Glucose Activation of the Acetyl-CoA Carboxylase Promoter, Journal of Biological Chemistry, vol.271, issue.3, pp.1385-1392, 1996.
DOI : 10.1074/jbc.271.3.1385

R. Deberardinis, J. Lum, G. Hatzivassiliou, and C. Thompson, The Biology of Cancer: Metabolic Reprogramming Fuels Cell Growth and Proliferation, Cell Metabolism, vol.7, issue.1, pp.11-20, 2008.
DOI : 10.1016/j.cmet.2007.10.002

P. Denechaud, R. Dentin, J. Girard, and C. Postic, Role of ChREBP in hepatic steatosis and insulin resistance, FEBS Letters, vol.340, issue.1, pp.68-73, 2008.
DOI : 10.1016/j.febslet.2007.07.084

R. Dentin, J. Pegorier, F. Benhamed, F. Foufelle, P. Ferre et al., Hepatic Glucokinase Is Required for the Synergistic Action of ChREBP and SREBP-1c on Glycolytic and Lipogenic Gene Expression, Journal of Biological Chemistry, vol.279, issue.19, pp.20314-20326, 2004.
DOI : 10.1074/jbc.M312475200

D. Dimova and N. Dyson, The E2F transcriptional network: old acquaintances with new faces, Oncogene, vol.15, issue.17, pp.2810-2826, 2005.
DOI : 10.1038/sj.onc.1208612

R. Elstrom, D. Bauer, M. Buzzai, R. Karnauskas, M. Harris et al., Akt Stimulates Aerobic Glycolysis in Cancer Cells, Cancer Research, vol.64, issue.11, pp.3892-3899, 2004.
DOI : 10.1158/0008-5472.CAN-03-2904

E. Fabbrizio, E. Messaoudi, S. Polanowska, J. Paul, C. Cook et al., Negative regulation of transcription by the type II arginine methyltransferase PRMT5, EMBO Reports, vol.3, issue.7, pp.641-645, 2002.
DOI : 10.1093/embo-reports/kvf136

L. Fajas, V. Egler, R. Reiter, J. Hansen, K. Kristiansen et al., The Retinoblastoma-Histone Deacetylase 3 Complex Inhibits PPAR?? and Adipocyte Differentiation, Developmental Cell, vol.3, issue.6, pp.903-910, 2002.
DOI : 10.1016/S1534-5807(02)00360-X

L. Fajas, R. Landsberg, Y. Huss-garcia, C. Sardet, J. Lees et al., E2Fs Regulate Adipocyte Differentiation, Developmental Cell, vol.3, issue.1, pp.39-49, 2002.
DOI : 10.1016/S1534-5807(02)00190-9
URL : http://doi.org/10.1016/s1534-5807(02)00190-9

L. Fajas, J. Annicotte, S. Miard, D. Sarruf, M. Watanabe et al., Impaired pancreatic growth, ?? cell mass, and ?? cell function in E2F1 ???/??? mice, Journal of Clinical Investigation, vol.113, issue.9, pp.1288-1295, 2004.
DOI : 10.1172/JCI18555

S. Field, F. Tsai, F. Kuo, A. Zubiaga, W. Kaelin et al., E2F-1 Functions in Mice to Promote Apoptosis and Suppress Proliferation, Cell, vol.85, issue.4, pp.549-561, 1996.
DOI : 10.1016/S0092-8674(00)81255-6

K. Gottlob, N. Majewski, S. Kennedy, E. Kandel, R. Robey et al., Inhibition of early apoptotic events by Akt/PKB is dependent on the first committed step of glycolysis and mitochondrial hexokinase, Genes & Development, vol.15, issue.11, pp.1406-1418, 2001.
DOI : 10.1101/gad.889901

K. Helin, Regulation of cell proliferation by the E2F transcription factors, Current Opinion in Genetics & Development, vol.8, issue.1, pp.28-35, 1998.
DOI : 10.1016/S0959-437X(98)80058-0

M. Hsieh, D. Das, N. Sambandam, M. Zhang, and Z. Nahle, Regulation of the PDK4 Isozyme by the Rb-E2F1 Complex, Journal of Biological Chemistry, vol.283, issue.41, pp.27410-27417, 2008.
DOI : 10.1074/jbc.M802418200

A. Iglesias, M. Murga, U. Laresgoiti, A. Skoudy, I. Bernales et al., Diabetes and exocrine pancreatic insufficiency in E2F1/E2F2 double-mutant mice, Journal of Clinical Investigation, vol.113, issue.10, pp.1398-1407, 2004.
DOI : 10.1172/JCI18879DS1

P. Jezek, L. Plecita-hlavata, K. Smolkova, and R. Rossignol, Distinctions and similarities of cell bioenergetics and the role of mitochondria in hypoxia, cancer, and embryonic development, The International Journal of Biochemistry & Cell Biology, vol.42, issue.5, pp.604-622, 2010.
DOI : 10.1016/j.biocel.2009.11.008

J. Kim, J. Lee, and V. Iyer, Global Identification of Myc Target Genes Reveals Its Direct Role in Mitochondrial Biogenesis and Its E-Box Usage In Vivo, PLoS ONE, vol.287, issue.3, p.1798, 2008.
DOI : 10.1371/journal.pone.0001798.s005

J. Kim, K. Zeller, Y. Wang, A. Jegga, B. Aronow et al., Evaluation of Myc E-Box Phylogenetic Footprints in Glycolytic Genes by Chromatin Immunoprecipitation Assays, Molecular and Cellular Biology, vol.24, issue.13, pp.5923-5936, 2004.
DOI : 10.1128/MCB.24.13.5923-5936.2004

J. Kim, P. Gao, Y. Liu, G. Semenza, and C. Dang, Hypoxia-Inducible Factor 1 and Dysregulated c-Myc Cooperatively Induce Vascular Endothelial Growth Factor and Metabolic Switches Hexokinase 2 and Pyruvate Dehydrogenase Kinase 1, Molecular and Cellular Biology, vol.27, issue.21, pp.7381-7393, 2007.
DOI : 10.1128/MCB.00440-07

G. Kroemer and J. Pouyssegur, Tumor Cell Metabolism: Cancer's Achilles' Heel, Cancer Cell, vol.13, issue.6, pp.472-482, 2008.
DOI : 10.1016/j.ccr.2008.05.005
URL : http://doi.org/10.1016/j.ccr.2008.05.005

F. Kuhajda, K. Jenner, F. Wood, R. Hennigar, L. Jacobs et al., Fatty acid synthesis: a potential selective target for antineoplastic therapy., Proceedings of the National Academy of Sciences, vol.91, issue.14, pp.6379-6383, 1994.
DOI : 10.1073/pnas.91.14.6379

F. Kuhajda, Fatty-acid synthase and human cancer: new perspectives on its role in tumor biology, Nutrition, vol.16, issue.3, pp.202-208, 2000.
DOI : 10.1016/S0899-9007(99)00266-X

B. Lewis, J. Prescott, S. Campbell, H. Shim, R. Orlowski et al., Tumor induction by the c-Myc target genes rcl and lactate dehydrogenase A, Cancer Res, vol.60, pp.6178-6183, 2000.

F. Li, Y. Wang, K. Zeller, J. Potter, D. Wonsey et al., Myc Stimulates Nuclearly Encoded Mitochondrial Genes and Mitochondrial Biogenesis, Molecular and Cellular Biology, vol.25, issue.14, pp.6225-6234, 2005.
DOI : 10.1128/MCB.25.14.6225-6234.2005
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1168798

F. Li, J. Zhu, J. Tessem, J. Beilke, M. Varella-garcia et al., The development of diabetes in E2f1/E2f2 mutant mice reveals important roles for bone marrow-derived cells in preventing islet cell loss, Proceedings of the National Academy of Sciences, vol.100, issue.22, pp.12935-12940, 2003.
DOI : 10.1073/pnas.2231861100

J. Li, Y. C. Liaw, D. Podsypanina, K. Bose, S. Wang et al., PTEN, a Putative Protein Tyrosine Phosphatase Gene Mutated in Human Brain, Breast, and Prostate Cancer, Science, vol.275, issue.5308, pp.1943-1947, 1997.
DOI : 10.1126/science.275.5308.1943

Y. Liu, F. Li, J. Handler, C. Huang, Y. Xiang et al., Global Regulation of Nucleotide Biosynthetic Genes by c-Myc, PLoS ONE, vol.286, issue.2, p.2722, 2008.
DOI : 10.1371/journal.pone.0002722.s006

S. Lu and M. Archer, lipogenesis and proliferation in cancer cells, International Journal of Cancer, vol.70, issue.Pt 2, pp.416-425, 2009.
DOI : 10.1002/ijc.24761

N. Majewski, V. Nogueira, P. Bhaskar, P. Coy, J. Skeen et al., Hexokinase-Mitochondria Interaction Mediated by Akt Is Required to Inhibit Apoptosis in the Presence or Absence of Bax and Bak, Molecular Cell, vol.16, issue.5, pp.819-830, 2004.
DOI : 10.1016/j.molcel.2004.11.014

B. Manning and L. Cantley, AKT/PKB Signaling: Navigating Downstream, Cell, vol.129, issue.7, pp.1261-1274, 2007.
DOI : 10.1016/j.cell.2007.06.009
URL : http://doi.org/10.1016/j.cell.2007.06.009

S. Matoba, J. Kang, W. Patino, A. Wragg, M. Boehm et al., p53 Regulates Mitochondrial Respiration, Science, vol.312, issue.5780, pp.1650-1653, 2006.
DOI : 10.1126/science.1126863

S. Mazurek, W. Zwerschke, P. Jansen-durr, and E. Eigenbrodt, Metabolic cooperation between different oncogenes during cell transformation: interaction between activated ras and HPV-16 E7, Oncogene, vol.20, issue.47, pp.6891-6898, 2001.
DOI : 10.1038/sj.onc.1204792

G. Medes, A. Thomas, and S. Weinhouse, Metabolism of neoplastic tissue. IV. A study of lipid synthesis in neoplastic tissue slices in vitro, Cancer Res, vol.13, pp.27-29, 1953.

J. Menendez, R. Colomer, and R. Lupu, Why does tumor-associated fatty acid synthase (oncogenic antigen-519) ignore dietary fatty acids?, Medical Hypotheses, vol.64, issue.2, pp.342-349, 2005.
DOI : 10.1016/j.mehy.2004.07.022

J. Menendez and R. Lupu, Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis, Nature Reviews Cancer, vol.280, issue.10, pp.763-777, 2007.
DOI : 10.1038/nrc2222

Y. Moon, K. Kim, U. Cho, D. Yoon, and S. Park, Characterization of regulatory elements on the promoter region of human ATP-citrate lyase, Experimental & Molecular Medicine, vol.31, issue.2, pp.108-114, 1999.
DOI : 10.1038/emm.1999.18

F. Morrish, N. Neretti, J. Sedivy, and D. Hockenbery, The oncogene c-Myc coordinates regulation of metabolic networks to enable rapid cell cycle entry, Cell Cycle, vol.7, issue.8, pp.1054-1066, 2008.
DOI : 10.4161/cc.7.8.5739

M. Nadolski and M. Linder, Protein lipidation, FEBS Journal, vol.195, issue.20, pp.5202-5210, 2007.
DOI : 10.1111/j.1742-4658.2007.06056.x

R. Osthus, H. Shim, S. Kim, Q. Li, R. Reddy et al., Deregulation of Glucose Transporter 1 and Glycolytic Gene Expression by c-Myc, Journal of Biological Chemistry, vol.275, issue.29, pp.21797-21800, 2000.
DOI : 10.1074/jbc.C000023200

T. Porstmann, C. Santos, C. Lewis, B. Griffiths, and A. Schulze, A new player in the orchestra of cell growth: SREBP activity is regulated by mTORC1 and contributes to the regulation of cell and organ size, Biochemical Society Transactions, vol.37, issue.1, pp.278-283, 2009.
DOI : 10.1042/BST0370278

A. Ramanathan, C. Wang, and S. Schreiber, Perturbational profiling of a cell-line model of tumorigenesis by using metabolic measurements, Proceedings of the National Academy of Sciences, vol.102, issue.17, pp.5992-5997, 2005.
DOI : 10.1073/pnas.0502267102

R. Robey and N. Hay, Mitochondrial hexokinases, novel mediators of the antiapoptotic effects of growth factors and Akt, Oncogene, vol.25, issue.25, pp.4683-4696, 2006.
DOI : 10.1016/j.bbrc.2005.03.191

J. Sabine, S. Abraham, and I. Chaikoff, Control of lipid metabolism in hepatomas: insensitivity of rate of fatty acid and cholesterol synthesis by mouse hepatoma BW7756 to fasting and to feedback control, Cancer Res, vol.27, pp.793-799, 1967.

D. Sarruf, I. Iankova, A. Abella, S. Assou, S. Miard et al., Cyclin D3 Promotes Adipogenesis through Activation of Peroxisome Proliferator-Activated Receptor ??, Molecular and Cellular Biology, vol.25, issue.22, pp.9985-9995, 2005.
DOI : 10.1128/MCB.25.22.9985-9995.2005
URL : https://hal.archives-ouvertes.fr/inserm-00144667

N. Scaglia and R. Igal, Inhibition of Stearoyl-CoA Desaturase 1 expression in human lung adenocarcinoma cells impairs tumorigenesis, Int J Oncol, vol.33, pp.839-850, 2008.

F. Schwartzenberg-bar-yoseph, M. Armoni, and E. Karnieli, The Tumor Suppressor p53 Down-Regulates Glucose Transporters GLUT1 and GLUT4 Gene Expression, Cancer Research, vol.64, issue.7, pp.2627-2633, 2004.
DOI : 10.1158/0008-5472.CAN-03-0846

H. Shim, C. Dolde, B. Lewis, C. Wu, G. Dang et al., c-Myc transactivation of LDH-A: Implications for tumor metabolism and growth, Proceedings of the National Academy of Sciences, vol.94, issue.13, pp.6658-6663, 1997.
DOI : 10.1073/pnas.94.13.6658

B. Stiles, Y. Wang, A. Stahl, S. Bassilian, W. Lee et al., Liver-specific deletion of negative regulator Pten results in fatty liver and insulin hypersensitivity, Proceedings of the National Academy of Sciences, vol.101, issue.7, pp.2082-2087, 2004.
DOI : 10.1073/pnas.0308617100

E. Tasdemir, M. Maiuri, L. Galluzzi, I. Vitale, M. Djavaheri-mergny et al., Regulation of autophagy by cytoplasmic p53, Nature Cell Biology, vol.13, issue.6, pp.676-687, 2008.
DOI : 10.1093/emboj/19.21.5720

X. Tong, F. Zhao, A. Mancuso, J. Gruber, and C. Thompson, The glucose-responsive transcription factor ChREBP contributes to glucose-dependent anabolic synthesis and cell proliferation, Proceedings of the National Academy of Sciences, vol.106, issue.51, pp.21660-21665, 2009.
DOI : 10.1073/pnas.0911316106

M. Vander-heiden, L. Cantley, and C. Thompson, Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation, Science, vol.324, issue.5930, pp.1029-1033, 2009.
DOI : 10.1126/science.1160809

O. Warburg, Metabolism of Tumors, 1930.

O. Warburg, On the Origin of Cancer Cells, Science, vol.123, issue.3191, pp.309-314, 1956.
DOI : 10.1126/science.123.3191.309

O. Warburg, On respiratory impairment in cancer cells, Science, vol.124, pp.269-270, 1956.

H. Wieman, J. Wofford, and J. Rathmell, Cytokine Stimulation Promotes Glucose Uptake via Phosphatidylinositol-3 Kinase/Akt Regulation of Glut1 Activity and Trafficking, Molecular Biology of the Cell, vol.18, issue.4, pp.1437-1446, 2007.
DOI : 10.1091/mbc.E06-07-0593

N. Wijesekara, D. Konrad, M. Eweida, C. Jefferies, N. Liadis et al., Muscle-Specific Pten Deletion Protects against Insulin Resistance and Diabetes, Molecular and Cellular Biology, vol.25, issue.3, pp.1135-1145, 2005.
DOI : 10.1128/MCB.25.3.1135-1145.2005
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC544010

J. Wofford, H. Wieman, S. Jacobs, Y. Zhao, and J. Rathmell, IL-7 promotes Glut1 trafficking and glucose uptake via STAT5-mediated activation of Akt to support T-cell survival, Blood, vol.111, issue.4, pp.2101-2111, 2008.
DOI : 10.1182/blood-2007-06-096297

S. Xiong, S. Chirala, and S. Wakil, Sterol regulation of human fatty acid synthase promoter I requires nuclear factor-Y- and Sp-1-binding sites, Proceedings of the National Academy of Sciences, vol.97, issue.8, pp.3948-3953, 2000.
DOI : 10.1073/pnas.040574197

L. Xue, D. Gollapalli, P. Maiti, W. Jahng, and R. Rando, A Palmitoylation Switch Mechanism in the Regulation of the Visual Cycle, Cell, vol.117, issue.6, pp.761-771, 2004.
DOI : 10.1016/j.cell.2004.05.016

L. Yamasaki, T. Jacks, R. Bronson, E. Goillot, E. Harlow et al., Tumor Induction and Tissue Atrophy in Mice Lacking E2F-1, Cell, vol.85, issue.4, pp.537-548, 1996.
DOI : 10.1016/S0092-8674(00)81254-4

Y. Yang, W. Han, P. Morin, F. Chrest, and E. Pizer, Activation of Fatty Acid Synthesis during Neoplastic Transformation: Role of Mitogen-Activated Protein Kinase and Phosphatidylinositol 3-Kinase, Experimental Cell Research, vol.279, issue.1, pp.80-90, 2002.
DOI : 10.1006/excr.2002.5600