Metabolism and proliferation share common regulatory pathways in cancer cells. - Inserm - Institut national de la santé et de la recherche médicale Accéder directement au contenu
Article Dans Une Revue Oncogene Année : 2010

Metabolism and proliferation share common regulatory pathways in cancer cells.

Résumé

Cancer development involves major alterations in cells' metabolism. Enhanced glycolysis and de novo fatty acids synthesis are indeed characteristic features of cancer. Cell proliferation and metabolism are tightly linked cellular processes. Others and we have previously shown a close relationship between metabolic responses and proliferative stimuli. In addition to trigger proliferative and survival signaling pathways, most oncoproteins also trigger metabolic changes to transform the cell. We present herein the view that participation of cell-cycle regulators and oncogenic proteins to cancer development extend beyond the control of cell proliferation, and discuss how these new functions may be implicated in metabolic alterations concomitant to the pathogenesis of human cancers.

Domaines

Cancer
Fichier principal
Vignette du fichier
29777_1_merged_1271230065.pdf (158.34 Ko) Télécharger le fichier
inserm-00491405_edited.pdf (386.46 Ko) Télécharger le fichier
Origine : Fichiers produits par l'(les) auteur(s)
Origine : Fichiers produits par l'(les) auteur(s)
Loading...

Dates et versions

inserm-00491405 , version 1 (02-12-2010)

Identifiants

Citer

Vanessa Fritz, Lluis Fajas. Metabolism and proliferation share common regulatory pathways in cancer cells.: metabolism, proliferation, and cancer. Oncogene, 2010, 29 (31), pp.4369-77. ⟨10.1038/onc.2010.182⟩. ⟨inserm-00491405⟩
298 Consultations
1499 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More