Skip to Main content Skip to Navigation
Journal articles

Metabolism and proliferation share common regulatory pathways in cancer cells.: metabolism, proliferation, and cancer

Abstract : Cancer development involves major alterations in cells' metabolism. Enhanced glycolysis and de novo fatty acids synthesis are indeed characteristic features of cancer. Cell proliferation and metabolism are tightly linked cellular processes. Others and we have previously shown a close relationship between metabolic responses and proliferative stimuli. In addition to trigger proliferative and survival signaling pathways, most oncoproteins also trigger metabolic changes to transform the cell. We present herein the view that participation of cell-cycle regulators and oncogenic proteins to cancer development extend beyond the control of cell proliferation, and discuss how these new functions may be implicated in metabolic alterations concomitant to the pathogenesis of human cancers.
Document type :
Journal articles
Complete list of metadatas

Cited literature [71 references]  Display  Hide  Download

https://www.hal.inserm.fr/inserm-00491405
Contributor : Yves Le Ster <>
Submitted on : Thursday, December 2, 2010 - 1:54:05 PM
Last modification on : Wednesday, October 3, 2018 - 4:02:22 PM
Long-term archiving on: : Thursday, March 3, 2011 - 2:30:36 AM

Files

29777_1_merged_1271230065.pdf
Files produced by the author(s)

Identifiers

Collections

Citation

Vanessa Fritz, Lluis Fajas. Metabolism and proliferation share common regulatory pathways in cancer cells.: metabolism, proliferation, and cancer. Oncogene, Nature Publishing Group, 2010, 29 (31), pp.4369-77. ⟨10.1038/onc.2010.182⟩. ⟨inserm-00491405⟩

Share

Metrics

Record views

337

Files downloads

2205