Combining naturally occurring polyphenols with TNF-related apoptosis-inducing ligand: a promising approach to kill resistant cancer cells? - Archive ouverte HAL Access content directly
Journal Articles Cellular and Molecular Life Sciences Year : 2010

Combining naturally occurring polyphenols with TNF-related apoptosis-inducing ligand: a promising approach to kill resistant cancer cells?

(1) , (1) , (1, 2)
1
2

Abstract

TNF-related apoptosis-inducing ligand (TRAIL) and its receptors are attractive targets for anticancer therapy owing to their ability to trigger apoptosis selectively in cancer cells but not in normal cells. To date, many combinatorial strategies, such as chemotherapy or radiotherapy, have given encouraging results for overcoming TRAIL resistance in preclinical models. In this review, we provide an overview of the molecular mechanisms underlying sensitization to TRAIL-induced apoptosis by polyphenols. These naturally occurring compounds can restore tumor cell sensitivity to TRAIL-induced cell death with no apparent toxicity towards normal cells. Both extrinsic and intrinsic pathways can be modulated by polyphenols, the activation of which largely depends on the cell type, the particular polyphenolic compound, and the conditions of treatment. The large variety of polyphenol cellular targets could prove useful in circumventing TRAIL resistance. The relevance of these combined treatments for cancer therapy is discussed in the light of recent preclinical studies.
Fichier principal
Vignette du fichier
Fig_Legends.pdf (47.06 Ko) Télécharger le fichier
Vignette du fichier
Figures_cmls.pdf (2.03 Mo) Télécharger le fichier
Vignette du fichier
Review-jacquemin-R1.pdf (253 Ko) Télécharger le fichier
Origin : Files produced by the author(s)
Origin : Files produced by the author(s)
Origin : Files produced by the author(s)

Dates and versions

inserm-00491262 , version 1 (11-06-2010)

Identifiers

Cite

Guillaume Jacquemin, Sarah Shirley, Olivier Micheau. Combining naturally occurring polyphenols with TNF-related apoptosis-inducing ligand: a promising approach to kill resistant cancer cells?: TRAIL and polyphenols in anticancer therapy.. Cellular and Molecular Life Sciences, 2010, 67 (18), pp.3115-30. ⟨10.1007/s00018-010-0407-6⟩. ⟨inserm-00491262⟩
155 View
881 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More