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Overtime work and incident coronary heart disease: the Whitehall II prospective cohort study.

Abstract : AIMS: To examine the association between overtime work and incident coronary heart disease (CHD) among middle-aged employees. METHODS AND RESULTS: Six thousand and fourteen British civil servants (4262 men and 1752 women), aged 39-61 years who were free from CHD and worked full time at baseline (1991-1994), were followed until 2002-2004, an average of 11 years. The outcome measure was incident fatal CHD, clinically verified incident non-fatal myocardial infarction (MI), or definite angina (a total of 369 events). Cox proportional hazard models adjusted for sociodemographic characteristics showed that 3-4 h overtime work per day was associated with 1.60-fold (95% CI 1.15-2.23) increased risk of incident CHD compared with employees with no overtime work. Adjustment for all 21 cardiovascular risk factors measured made little difference to these estimates (HR 1.56, 95% CI 1.11-2.19). This association was replicated in multivariate analysis with only fatal cardiovascular disease and incident non-fatal MI as the outcome (HR 1.67, 95% CI 1.02-2.76). CONCLUSION: Overtime work is related to increased risk of incident CHD independently of conventional risk factors. These findings suggest that overtime work adversely affects coronary health.
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Submitted on : Friday, May 13, 2011 - 11:56:30 AM
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Marianna Virtanen, Jane E. Ferrie, Archana Singh-Manoux, Martin J. Shipley, Jussi Vahtera, et al.. Overtime work and incident coronary heart disease: the Whitehall II prospective cohort study.. European Heart Journal, Oxford University Press (OUP): Policy B, 2010, 31 (14), pp.1737-44. ⟨10.1093/eurheartj/ehq124⟩. ⟨inserm-00488827⟩



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