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Decreased seizure threshold and more rapid rate of kindling in rats with cortical malformation induced by prenatal treatment with methylazoxymethanol.

Abstract : In humans, cortical malformations are highly epileptogenic. In rats, prenatal treatment with methylazoxymethanol (MAM) cause a diffuse cortical malformation that is yet not associated with seizures. We performed rapid hippocampal kindling in MAM and control rats. We show that MAM rats present (i) a lower initial afterdischarge threshold; (ii) a more rapid progression to generalized seizures. We conclude that MAM rats may serve as models for human epileptogenic cortical malformations.
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https://www.hal.inserm.fr/inserm-00487297
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  • HAL Id : inserm-00487297, version 1
  • PUBMED : 9813354

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Nicolas Chevassus-Au-Louis, Yehezkel Ben-Ari, Marguerite Vergnes. Decreased seizure threshold and more rapid rate of kindling in rats with cortical malformation induced by prenatal treatment with methylazoxymethanol.. Brain Research, Elsevier, 1998, 812 (1-2), pp.252-5. ⟨inserm-00487297⟩

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