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Journal articles
Decreased seizure threshold and more rapid rate of kindling in rats with cortical malformation induced by prenatal treatment with methylazoxymethanol.
Abstract : In humans, cortical malformations are highly epileptogenic. In rats, prenatal treatment with methylazoxymethanol (MAM) cause a diffuse cortical malformation that is yet not associated with seizures. We performed rapid hippocampal kindling in MAM and control rats. We show that MAM rats present (i) a lower initial afterdischarge threshold; (ii) a more rapid progression to generalized seizures. We conclude that MAM rats may serve as models for human epileptogenic cortical malformations.
https://www.hal.inserm.fr/inserm-00487297
Contributor : Roman Tyzio <>
Submitted on : Friday, May 28, 2010 - 3:28:51 PM
Last modification on : Friday, March 27, 2020 - 2:37:19 AM
Long-term archiving on: : Thursday, December 1, 2016 - 5:59:40 PM
Contributor : Roman Tyzio <>
Submitted on : Friday, May 28, 2010 - 3:28:51 PM
Last modification on : Friday, March 27, 2020 - 2:37:19 AM
Long-term archiving on: : Thursday, December 1, 2016 - 5:59:40 PM