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Journal articles
Dual role of GABA in the neonatal rat hippocampus.
Abstract : The effects of modulators of GABA-A receptors on neuronal network activity were studied in the neonatal (postnatal days 0-5) rat hippocampus in vitro. Under control conditions, the physiological pattern of activity of the neonatal hippocampal network was characterized by spontaneous network-driven giant depolarizing potentials (GDPs). The GABA-A receptor agonist isoguvacine (1-2 microM) and the allosteric modulator diazepam (2 microM) induced biphasic responses: initially the frequency of GDPs increased 3 to 4 fold followed by blockade of GDPs and desynchronization of the network activity. The GABA-A receptor antagonists bicuculline (10 microM) and picrotoxin (100 microM) blocked GDPs and induced glutamate (AMPA and NMDA)-receptor-mediated interictal- and ictal-like activities in the hippocampal slices and the intact hippocampus. These data suggest that at early postnatal ages GABA can exert a dual - both excitatory and inhibitory - action on the network activity.
https://www.hal.inserm.fr/inserm-00486267
Contributor : Roman Tyzio <>
Submitted on : Tuesday, May 25, 2010 - 2:32:26 PM
Last modification on : Thursday, March 5, 2020 - 6:59:42 PM
Long-term archiving on: : Wednesday, November 30, 2016 - 10:52:33 PM
Contributor : Roman Tyzio <>
Submitted on : Tuesday, May 25, 2010 - 2:32:26 PM
Last modification on : Thursday, March 5, 2020 - 6:59:42 PM
Long-term archiving on: : Wednesday, November 30, 2016 - 10:52:33 PM