Dual role of GABA in the neonatal rat hippocampus. - Archive ouverte HAL Access content directly
Journal Articles Developmental Neuroscience Year : 1999

Dual role of GABA in the neonatal rat hippocampus.

(1, 2) , (1) , (1) , (1, 2)
1
2

Abstract

The effects of modulators of GABA-A receptors on neuronal network activity were studied in the neonatal (postnatal days 0-5) rat hippocampus in vitro. Under control conditions, the physiological pattern of activity of the neonatal hippocampal network was characterized by spontaneous network-driven giant depolarizing potentials (GDPs). The GABA-A receptor agonist isoguvacine (1-2 microM) and the allosteric modulator diazepam (2 microM) induced biphasic responses: initially the frequency of GDPs increased 3 to 4 fold followed by blockade of GDPs and desynchronization of the network activity. The GABA-A receptor antagonists bicuculline (10 microM) and picrotoxin (100 microM) blocked GDPs and induced glutamate (AMPA and NMDA)-receptor-mediated interictal- and ictal-like activities in the hippocampal slices and the intact hippocampus. These data suggest that at early postnatal ages GABA can exert a dual - both excitatory and inhibitory - action on the network activity.
Embargoed file
Embargoed file
Ne sera jamais visible

Dates and versions

inserm-00486267 , version 1 (25-05-2010)

Identifiers

  • HAL Id : inserm-00486267 , version 1
  • PUBMED : 10575254

Cite

Ilgam Khalilov, Volodymyr Dzhala, Yehezkel Ben-Ari, Roustem Khazipov. Dual role of GABA in the neonatal rat hippocampus.. Developmental Neuroscience, 1999, 21 (3-5), pp.310-9. ⟨inserm-00486267⟩

Collections

INSERM UNIV-AMU
232 View
0 Download

Altmetric

Share

Gmail Facebook Twitter LinkedIn More