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Dual role of GABA in the neonatal rat hippocampus.

Abstract : The effects of modulators of GABA-A receptors on neuronal network activity were studied in the neonatal (postnatal days 0-5) rat hippocampus in vitro. Under control conditions, the physiological pattern of activity of the neonatal hippocampal network was characterized by spontaneous network-driven giant depolarizing potentials (GDPs). The GABA-A receptor agonist isoguvacine (1-2 microM) and the allosteric modulator diazepam (2 microM) induced biphasic responses: initially the frequency of GDPs increased 3 to 4 fold followed by blockade of GDPs and desynchronization of the network activity. The GABA-A receptor antagonists bicuculline (10 microM) and picrotoxin (100 microM) blocked GDPs and induced glutamate (AMPA and NMDA)-receptor-mediated interictal- and ictal-like activities in the hippocampal slices and the intact hippocampus. These data suggest that at early postnatal ages GABA can exert a dual - both excitatory and inhibitory - action on the network activity.
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Submitted on : Tuesday, May 25, 2010 - 2:32:26 PM
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  • HAL Id : inserm-00486267, version 1
  • PUBMED : 10575254



Ilgam Khalilov, Volodymyr Dzhala, yehezkel Ben-Ari, Roustem Khazipov. Dual role of GABA in the neonatal rat hippocampus.. Developmental Neuroscience, Karger, 1999, 21 (3-5), pp.310-9. ⟨inserm-00486267⟩



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