Comment se comparent néphrectomies partielles et élargies pour le traitement des carcinomes papillaires pT1aN0M0 ? Étude comparative rétrospective de 277 cas. [How radical nephrectomy compares to partial nephrectomy for the treatment of pT1a papillary renal cell carcinomas?]

Pierre Bigot 1, 2 Jean-Christophe Bernhard 3 Maxime Crépel 1 Karim Bensalah 1 Alexandre De La Taille 4 Laurent Salomon 4 Jacques Tostain 5 Vincenzo Ficarra 6 Allan J Pantuck 7 Arie S Belldegrun 7 Arnaud Méjean 8 Jean-Marie Ferrière 3 Christian Pfister 9 Baptiste Albouy 9 Marc Colombel 10 Laurent Zini 11 Arnauld Villers 11 Francesco Montorsi 12 Shahrokh Shariat 13 Nathalie Rioux-Leclercq 14 Jean-Jacques Patard 1, *
* Auteur correspondant
1 IGDR - Institut de Génétique et Développement de Rennes
2 Service d'urologie
3 Service d'urologie, andrologie et transplantation rénale
4 Service d'urologie [Mondor]
5 Service d'urologie-andrologie
6 Departement of Oncological and Surgical Sciences
7 Department of Urology
8 Service d'urologie
9 Service d'urologie [Rouen]
10 Service d'urologie [Centre Hospitalier Lyon Sud - HCL]
11 Service d'urologie
12 Department of urology
13 Division of Urology
14 Service d'anatomie et cytologie pathologiques [Rennes]
Abstract : PURPOSE: Our objective was to compare oncologic results of nephron sparing surgery (NSS) versus radical nephrectomy (RN) in T1aN0-x M0 papillary renal cell carcinoma (PRCC). PATIENTS AND METHODS: We retrospectively reviewed 277 patients treated for a pT1aN0M0 PRCC selected from an academic database from 12 centres. We compared the clinico-pathological features by using Chi-square and Student statistical analyses. Survivals analyses using Kaplan-Meier and Log-rank models were performed. RESULTS: The two groups were composed by 186 patients treated by NSS and 91 by RN. The TNM stage was fixed and the two groups were, in terms of age and Fuhrman grade, comparable. Median age at diagnosis was 59 years (27-85). Median tumor size was 2.7 cm (0.4-4). The average follow-up was 49 months (1-246). Very few events arose in both groups: two local recurrences were observed in the NSS group (1.07%), three patients died of cancer in the NSS treated group (1.6%) and five in the RN treated group (5.5%). The five and 10 cancer-specific survival rate were comparable in the two groups (98% vs. 100% and 98% vs. 97%). The specific survival curves were perfectly similar for both groups (log rank test, p=0.25). CONCLUSION: NSS is equivalent to RN as far as oncologic control of pT1aN0M0 PRCC is concerned.
Type de document :
Article dans une revue
Progrès en Urologie, Elsevier Masson, 2010, 20 (5), pp.350-5. 〈10.1016/j.purol.2010.01.007〉
Liste complète des métadonnées
http://www.hal.inserm.fr/inserm-00486239
Contributeur : Hervé De Villemeur <>
Soumis le : mardi 25 mai 2010 - 13:55:04
Dernière modification le : jeudi 14 juin 2018 - 10:54:02

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Pierre Bigot, Jean-Christophe Bernhard, Maxime Crépel, Karim Bensalah, Alexandre De La Taille, et al.. Comment se comparent néphrectomies partielles et élargies pour le traitement des carcinomes papillaires pT1aN0M0 ? Étude comparative rétrospective de 277 cas. [How radical nephrectomy compares to partial nephrectomy for the treatment of pT1a papillary renal cell carcinomas?]. Progrès en Urologie, Elsevier Masson, 2010, 20 (5), pp.350-5. 〈10.1016/j.purol.2010.01.007〉. 〈inserm-00486239〉

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