Insulin resistance and pancreatic ?? cell failure, Journal of Clinical Investigation, vol.116, issue.7, pp.1756-1760, 2006. ,
DOI : 10.1172/JCI29189
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1483164
Role of nuclear receptors in the modulation of insulin secretion in lipid-induced insulin resistance, Biochemical Society Transactions, vol.36, issue.5, pp.891-900, 2008. ,
DOI : 10.1042/BST0360891
Identification of a Nuclear Receptor for Bile Acids, Science, vol.284, issue.5418, pp.1362-1365, 1999. ,
DOI : 10.1126/science.284.5418.1362
Endogenous Bile Acids Are Ligands for the Nuclear Receptor FXR/BAR, Molecular Cell, vol.3, issue.5, pp.543-553, 1999. ,
DOI : 10.1016/S1097-2765(00)80348-2
Bile Acids: Natural Ligands for an Orphan Nuclear Receptor, Science, vol.284, issue.5418, pp.1365-1368, 1999. ,
DOI : 10.1126/science.284.5418.1365
The Farnesoid X Receptor (FXR) as Modulator of Bile Acid Metabolism, Reviews in Endocrine and Metabolic Disorders, vol.5, issue.4, pp.319-326, 2004. ,
DOI : 10.1023/B:REMD.0000045103.00467.9a
Role of Bile Acids and Bile Acid Receptors in Metabolic Regulation, Physiological Reviews, vol.89, issue.1, pp.147-191, 2009. ,
DOI : 10.1152/physrev.00010.2008
Glucose Regulates the Expression of the Farnesoid X Receptor in Liver, Diabetes, vol.53, issue.4, pp.890-898, 2004. ,
DOI : 10.2337/diabetes.53.4.890
Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice, Proc. Natl. Acad. Sci. USA 103, pp.1006-1011, 2006. ,
DOI : 10.1073/pnas.0506982103
A Review of Bile Acid Sequestrants: Potential Mechanism(s) for Glucose-Lowering Effects in Type 2 Diabetes Mellitus, Postgraduate Medicine, vol.121, issue.sup1, pp.25-30, 2009. ,
DOI : 10.3810/pgm.2009.05.suppl53.290
Regulation of Carbohydrate Metabolism by the Farnesoid X Receptor, Endocrinology, vol.146, issue.3, pp.984-991, 2005. ,
DOI : 10.1210/en.2004-0965
Bile Acids Regulate Gluconeogenic Gene Expression via Small Heterodimer Partner-mediated Repression of Hepatocyte Nuclear Factor 4 and Foxo1, Journal of Biological Chemistry, vol.279, issue.22, pp.23158-23165, 2004. ,
DOI : 10.1074/jbc.M314322200
Farnesoid X receptor is essential for normal glucose homeostasis, Journal of Clinical Investigation, vol.116, issue.4, pp.1102-1109, 2006. ,
DOI : 10.1172/JCI25604
The Farnesoid X Receptor Modulates Adiposity and Peripheral Insulin Sensitivity in Mice, Journal of Biological Chemistry, vol.281, issue.16, pp.11039-11049, 2006. ,
DOI : 10.1074/jbc.M510258200
Temporal and quantitative correlations between insulin secretion and stably elevated or oscilatory cytoplasmic Ca 2+ in mouse pancreatic ?-cells, Diabetes, vol.47, pp.1266-1273, 1998. ,
Peroxisome Proliferator-Activated Receptor ?? Improves Pancreatic Adaptation to Insulin Resistance in Obese Mice and Reduces Lipotoxicity in Human Islets, Diabetes, vol.55, issue.6, pp.1605-1613, 2006. ,
DOI : 10.2337/db06-0016
Immunolocalization of farnesoid X receptor (FXR) in mouse tissues using tissue microarray, Acta Histochemica, vol.110, issue.1, pp.86-93, 2008. ,
DOI : 10.1016/j.acthis.2007.08.001
Regulation of the insulin gene by glucose and fatty acids, J. Nutr, vol.136, pp.873-876, 2006. ,
Diabetes, defective pancreatic morphogenesis, and abnormal enteroendocrine differentiation in BETA2/NeuroD-deficient??mice, Genes & Development, vol.11, issue.18, pp.2323-2334, 1997. ,
DOI : 10.1101/gad.11.18.2323
Pancreatic beta cells express a diverse set of homeobox genes., Proc.Natl. Acad. Sci. 91, pp.12203-12207, 1994. ,
DOI : 10.1073/pnas.91.25.12203
Definition of a novel growth factor-dependent signal cascade for the suppression of bile acid biosynthesis, Genes & Development, vol.17, issue.13, pp.1581-1591, 2003. ,
DOI : 10.1101/gad.1083503
Research Resource: Nuclear Hormone Receptor Expression in the Endocrine Pancreas, Molecular Endocrinology, vol.22, issue.10, pp.2353-2363, 2008. ,
DOI : 10.1210/me.2007-0568
The bile acid sensor FXR regulates insulin transcription and secretion, Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, vol.1802, issue.3, 2010. ,
DOI : 10.1016/j.bbadis.2010.01.002
Synergistic activation of the insulin gene promoter by the ?-cell-enriched transcription factors MafA, Beta2 and PDX-1, Biochem. Biophys. Acta, vol.1730, pp.41-46, 2005. ,
Attenuation of FGF signalling in mouse ?-cells leads to diabetes, Nature, vol.408, pp.864-868, 2000. ,
Fibroblast Growth Factor-19, a Novel Factor That Inhibits Hepatic Fatty Acid Synthesis, Journal of Biological Chemistry, vol.284, issue.15, pp.10023-10033, 2009. ,
DOI : 10.1074/jbc.M808818200
URL : http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2665057
Glucagon Receptor Knockout Mice Display Increased Insulin Sensitivity and Impaired ??-Cell Function, Diabetes, vol.55, issue.12, pp.3463-3469, 2006. ,
DOI : 10.2337/db06-0307
Glucokinase and IRS-2 are required for compensatory ?? cell hyperplasia in response to high-fat diet-induced insulin resistance, Journal of Clinical Investigation, vol.117, issue.1, 2007. ,
DOI : 10.1172/JCI17645DS1