The nuclear receptor FXR is expressed in pancreatic beta-cells and protects human islets from lipotoxicity.

Farnesoid X receptor (FXR) is highly expressed in liver and intestine where it controls bile acid (BA), lipid and glucose homeostasis. Here we show that FXR is expressed and functional, as assessed by target gene expression analysis, in human islets and beta-cell lines. FXR is predominantly cytosolic-localized in the islets of lean mice, but nuclear in obese mice. Compared to FXR+/+ mice, FXR-/- mice display a normal architecture and beta-cell mass but the expression of certain islet-specific genes is altered. Moreover, glucose-stimulated insulin secretion (GSIS) is impaired in the islets of FXR-/- mice. Finally, FXR activation protects human islets from lipotoxicity and ameliorates their secretory index.

Keywords

FXR type 2 diabetes islets lipotoxicity

Domains

Biochemistry, Molecular Biology

Fichier principal

Art_RISTEA.pdf (522.72 Ko)

Origin : Files produced by the author(s)

Marie-Hélène Derudas : Connect in order to contact the contributor

https://www.hal.inserm.fr/inserm-00485665

Submitted on : Friday, May 21, 2010-2:14:47 PM

Last modification on : Tuesday, May 23, 2023-3:30:50 AM

Long-term archiving on: Thursday, December 1, 2016-12:13:34 AM

Dates and versions

inserm-00485665 , version 1 (21-05-2010)

Identifiers

HAL Id : inserm-00485665 , version 1
DOI : 10.1016/j.febslet.2010.04.068
PUBMED : 20447400

Cite

Iuliana Ristea Popescu, Audrey Helleboid-Chapman, Anthony Lucas, Brigitte Vandewalle, Julie Dumont, et al.. The nuclear receptor FXR is expressed in pancreatic beta-cells and protects human islets from lipotoxicity.. FEBS Letters, 2010, 584 (13), pp.2845-51. ⟨10.1016/j.febslet.2010.04.068⟩. ⟨inserm-00485665⟩

Export

BibTeX TEI Dublin Core DC Terms EndNote Datacite

Collections

INSERM RIIP RIIP_LILLE UNIV-LILLE RNMCD

144 View

308 Download