Occurrence of minimal change nephrotic syndrome in classical Hodgkin lymphoma is closely related to the induction of c-mip in Hodgkin-Reed Sternberg cells and podocytes.

Vincent Audard 1 Shao-Yu Zhang 1 Christiane Copie-Bergman 1, 2 Catherine Rucker-Martin 3 Virginie Ory 1 Marina Candelier 1 Maryse Baia 1, 2 Philippe Lang 1, 4, 5 André Pawlak 1 Djillali Sahali 1, 4, 5, *
* Auteur correspondant
1 IMRB - Institut Mondor de Recherche Biomédicale
2 Département de pathologie [Mondor]
3 RTFSPP - Remodelage tissulaire et fonctionnel : signalisation et physio-pathologie
4 Service de néphrologie et transplantation
5 Institut francilien de recherche en néphrologie et transplantation
Abstract : It is currently considered that idiopathic minimal change nephrotic syndrome is an immune-mediated glomerular disease. Its association with classical Hodgkin lymphoma minimal change nephrotic syndrome (cHL-MCNS) suggests a molecular link, which remains to be elucidated. We analyzed the expression of cmaf inducing protein (c-mip) in lymphomatous tissues and kidney biopsy samples of patients with cHL-MCNS (n = 8) and in lymphomatous tissues of patients with isolated cHL (n = 9). Because c-mip affects the regulatory loop involving Fyn, we investigated possible structural defects in this signaling pathway, using laser capture microdissection, reverse transcription polymerase chain reaction, and Western blotting. We found that c-mip was selectively expressed in Hodgkin and Reed-Sternberg (HRS) cells and podocytes of patients with cHL-MCNS but is undetectable in patients with isolated cHL. We demonstrated that c-mip was specifically involved in the negative regulation of early proximal signaling through its interaction with phosphoprotein associated with glycosphingolipid-enriched microdomains and Fyn. We showed that the up-regulation of c-mip in cHL-MCNS was associated with a possible Fyn defect in HRS cells and podocytes. Moreover, we showed that c-mip was up-regulated in Fyn-deficient podocytes. c-mip may be a useful marker of cHL-MCNS and its induction reflects the dysregulation of proximal signaling.
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Blood, American Society of Hematology, 2010, 115 (18), pp.3756-62. 〈10.1182/blood-2009-11-251132〉
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Vincent Audard, Shao-Yu Zhang, Christiane Copie-Bergman, Catherine Rucker-Martin, Virginie Ory, et al.. Occurrence of minimal change nephrotic syndrome in classical Hodgkin lymphoma is closely related to the induction of c-mip in Hodgkin-Reed Sternberg cells and podocytes.. Blood, American Society of Hematology, 2010, 115 (18), pp.3756-62. 〈10.1182/blood-2009-11-251132〉. 〈inserm-00485558〉

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