J. Beckman, Peroxynitrite versus Hydroxyl Radical: The Role of Nitric Oxide in Superoxide-Dependent Cerebral Injurya, Annals of the New York Academy of Sciences, vol.73, issue.S1, pp.69-75, 1994.
DOI : 10.1111/j.1749-6632.1994.tb21791.x

J. Beckman, T. Beckman, T. Chen, P. Marshall, and F. B. , Apparent hydroxyl radical production by peroxynitrite: implications for endothelial injury from nitric oxide and superoxide., Proc. Natl. Acad. Sci. USA, pp.1620-1624, 1990.
DOI : 10.1073/pnas.87.4.1620

N. Benjelloun, S. Renolleau, A. Represa, Y. Ben-ari, and C. Charriaut-marlangue, Inflammatory Responses in the Cerebral Cortex After Ischemia in the P7 Neonatal Rat ?? Editorial Comment, Stroke, vol.30, issue.9, pp.1916-1924, 1999.
DOI : 10.1161/01.STR.30.9.1916

N. Berger, Poly(ADP-Ribose) in the Cellular Response to DNA Damage, Radiation Research, vol.101, issue.1, pp.4-15, 1985.
DOI : 10.2307/3576299

E. Bona, B. Johansson, and H. Hagberg, Sensorimotor Function and Neuropathology Five to Six Weeks after Hypoxia-Ischemia in Seven-Day-Old Rats, Pediatric Research, vol.5, issue.5, pp.678-683, 1997.
DOI : 10.1203/00006450-199711000-00021

P. Chan, Role of Oxidants in Ischemic Brain Damage, Stroke, vol.27, issue.6, pp.1124-1129, 1996.
DOI : 10.1161/01.STR.27.6.1124

C. Charriaut-marlangue, E. Richard, B. , and Y. , DNA damage and DNA damage-inducible protein Gadd45 following ischemia in the P7 neonatal rat, Developmental Brain Research, vol.116, issue.2, pp.133-140, 1999.
DOI : 10.1016/S0165-3806(99)00084-X

URL : https://hal.archives-ouvertes.fr/inserm-00486258

D. Choi, Excitotoxic cell death, Journal of Neurobiology, vol.68, issue.9, pp.1261-1276, 1992.
DOI : 10.1002/neu.480230915

D. Choi, Calcium: still center-stage in hypoxic-ischemic neuronal death, Trends in Neurosciences, vol.18, issue.2, pp.58-60, 1995.
DOI : 10.1016/0166-2236(95)80018-W

L. Coeroli, S. Renolleau, S. Arnaud, D. Plotkine, N. Cachin et al., Nitric Oxide Production and Perivascular Tyrosine Nitration Following Focal Ischemia in Neonatal Rat, Journal of Neurochemistry, vol.70, issue.6, pp.2516-2525, 1998.
DOI : 10.1046/j.1471-4159.1998.70062516.x

C. Cosi, H. Suzuki, D. Milani, L. Facci, M. Menegazzi et al., Poly(ADP-ribose) polymerase: Early involvement in glutamate-induced neurotoxicity in cultured cerebellar granule cells, Journal of Neuroscience Research, vol.284, issue.1, pp.38-46, 1994.
DOI : 10.1002/jnr.490390106

S. Cuzzocrea, B. Zingarelli, E. Gilad, P. Hake, A. Salzman et al., Protective effects of 3-aminobenzamide, an inhibitor of poly (ADP-ribose) synthase in a carrageenan-induced model of local inflammation, European Journal of Pharmacology, vol.342, issue.1, pp.67-76, 1998.
DOI : 10.1016/S0014-2999(97)01417-9

V. Dawson, Nitric oxide and focal cerebral ischemia: multiplicity of actions and diverse outcome, Cerebrovasc. Brain Metab. Rev, vol.6, pp.299-324, 1994.

M. Eliasson, K. Sampei, A. Mandir, P. D. Hurn, R. Traystman et al., Poly(ADP-ribose) polymerase gene disruption renders mice resistant to cerebral ischemia, Nature Medicine, vol.28, issue.10, pp.1089-1095, 1997.
DOI : 10.1016/0896-6273(92)90211-U

M. Endres, Z. Wang, S. Namura, C. Waeber, and M. Moskowitz, Ischemic brain injury is mediated by the activation of poly(ADPribose ) polymerase, J. Cereb. Blood Flow Metab, vol.17, pp.1143-1151, 1997.

M. Endres, G. Scott, A. Salzman, E. Kun, M. Moskowitz et al., Protective effects of 5-iodo-6-amino-1,2-benzopyrone, an inhibitor of poly(ADP-ribose) synthetase against peroxynitrite-induced glial damage and stroke development, European Journal of Pharmacology, vol.351, issue.3, pp.377-382, 1998.
DOI : 10.1016/S0014-2999(98)00381-1

E. Golanov and D. Reis, Contribution of Cerebral Edema to the Neuronal Salvage Elicited by Stimulation of Cerebellar Fastigial Nucleus after Occlusion of the Middle Cerebral Artery in Rat, Journal of Cerebral Blood Flow & Metabolism, vol.12, issue.1, pp.172-174, 1995.
DOI : 10.1161/01.STR.24.1.117

C. Iadecola, D. Pelligrino, M. Moskowitz, and N. Lassen, Nitric Oxide Synthase Inhibition and Cerebrovascular Regulation, Journal of Cerebral Blood Flow & Metabolism, vol.14, issue.1, pp.175-192, 1994.
DOI : 10.1038/jcbfm.1994.25

J. Oliver, F. Menissier-de-murcia, J. Andrianantsitohaina, R. Muller, S. Delarubia et al., Resistance to endotoxic shock as a consequence of defective NF-kappa B activation in poly (ADP-ribose) polymerase-1 deficient mice, The EMBO Journal, vol.18, issue.16, pp.4446-4454, 1999.
DOI : 10.1093/emboj/18.16.4446

M. I. Levene, Outcome after Asphyxial and Circulatory Disturbances in the Brain, International Journal of Technology Assessment in Health Care, vol.33, issue.S1, pp.113-117, 1991.
DOI : 10.1016/S0140-6736(86)90718-X

E. Lo, P. Bosque-hamilton, and M. W. , Inhibition of Poly(ADP-Ribose) Polymerase : Reduction of Ischemic Injury and Attenuation of N-Methyl-D-Aspartate??Induced Neurotransmitter Dysregulation ?? Editorial Comment: Reduction of Ischemic Injury and Attenuation of N-Methyl-D-Aspartate??Induced Neurotransmitter Dysregulation, Stroke, vol.29, issue.4, pp.830-836, 1998.
DOI : 10.1161/01.STR.29.4.830

O. H. Lowry, N. J. Rosebrough, A. L. Farr, and R. R. , Protein measurement with the Folin phenol reagent, J. Biol. Chem, vol.193, pp.265-272, 1951.

A. Pieper, A. Verma, J. Zhang, and S. Snyder, Poly (ADP-ribose) polymerase, nitric oxide and cell death, Trends in Pharmacological Sciences, vol.20, issue.4, pp.171-181, 1999.
DOI : 10.1016/S0165-6147(99)01292-4

S. Renolleau, D. Aggoun-zouaoui, Y. Ben-ari, and C. Charriaut-marlangue, A Model of Transient Unilateral Focal Ischemia With Reperfusion in the P7 Neonatal Rat : Morphological Changes Indicative of Apoptosis ?? Editorial Comment: Morphological Changes Indicative of Apoptosis, Stroke, vol.29, issue.7, pp.1454-1461, 1998.
DOI : 10.1161/01.STR.29.7.1454

S. Rothman and J. Olney, Glutamate and the pathophysiology of hypoxic-ischemic brain damage, Annals of Neurology, vol.56, issue.2, pp.105-111, 1985.
DOI : 10.1002/ana.410190202

M. Satoh and T. Lindahl, Role of poly(ADP-ribose) formation in DNA repair, Nature, vol.356, issue.6367, pp.356-358, 1992.
DOI : 10.1038/356356a0

G. Scott, L. Jakeman, B. Stokes, and C. Szabo, Peroxynitrite production and activation of poly (adenosine diphosphate-ribose) synthetase in spinal cord injury, Annals of Neurology, vol.94, issue.1, pp.120-124, 1999.
DOI : 10.1002/1531-8249(199901)45:1<120::AID-ART18>3.0.CO;2-I

A. Sun and J. Cheng, Neuroprotective effects of poly(ADPribose ) polymerase inhibitors in transient focal cerebral ischemia of rats, pp.104-108, 1998.

C. Szabo and V. Dawson, Role of poly(ADP-ribose) synthetase in inflammation and ischaemia???reperfusion, Trends in Pharmacological Sciences, vol.19, issue.7, pp.287-298, 1998.
DOI : 10.1016/S0165-6147(98)01193-6

C. Szabo, L. Lim, S. Cuzzocrea, S. Getting, B. Zingarelli et al., Inhibition of poly (ADP-ribose) Synthetase Attenuates Neutrophil Recruitment and Exerts Antiinflammatory Effects, The Journal of Experimental Medicine, vol.1092, issue.7, pp.1041-1049, 1997.
DOI : 10.1074/jbc.270.32.18966

K. Takahashi and J. Greenberg, The effect of reperfusion on neuroprotection using an inhibitor of poly(ADP-ribose) polymerase, NeuroReport, vol.10, issue.10, pp.2017-2022, 1999.
DOI : 10.1097/00001756-199907130-00005

K. Takahashi, J. Greenberg, P. Jackson, K. Maclin, and J. Zhang, Neuroprotective effects of inhibiting poly(ADP-ribose) synthase on focal cerebral ischemia in rats, J. Cereb. Blood Flow Metab, vol.17, pp.1137-1142, 1997.

K. Takahashi, A. Pieper, S. Croul, J. Zhang, S. Snyder et al., Post-treatment with an inhibitor of poly(ADP-ribose) polymerase attenuates cerebral damage in focal ischemia, Brain Research, vol.829, issue.1-2, pp.46-54, 1999.
DOI : 10.1016/S0006-8993(99)01335-9

C. Thiemermann, J. Bowes, F. Myint, and J. Vane, Inhibition of the activity of poly(ADP-ribose) synthase reduces ischemia? reperfusion injury in the heart and skeletal muscle, Proc. Natl. Acad. Sci. USA 94, pp.679-683, 1997.

T. Tokime, K. Nozaki, T. Sugino, H. Kikuchi, N. Hashimoto et al., Enhanced Poly(ADP-ribosyl)ation After Focal Ischemia in Rat Brain, Journal of Cerebral Blood Flow & Metabolism, vol.156, pp.991-997, 1998.
DOI : 10.1097/00004647-199809000-00008

J. Towfighi, N. Zec, J. Yager, C. Housman, and R. Vannucci, Temporal evolution of neuropathologic changes in an immature rat model of cerebral hypoxia: a light microscopic study, Acta Neuropathologica, vol.17, issue.4, pp.375-386, 1995.
DOI : 10.1007/BF00315011

L. Virag, A. Salzman, and C. Szabo, Poly(ADP-ribose) synthetase activation mediates mitochondrial injury during oxidantinduced cell death, J. Immunol, vol.161, pp.3753-3759, 1998.

F. Wahl, M. Allix, M. Plotkine, and R. Boulu, Neurological and behavioral outcomes of focal cerebral ischemia in rats, Stroke, vol.23, issue.2, pp.267-272, 1992.
DOI : 10.1161/01.STR.23.2.267

M. Whalen, R. Clark, C. Dixon, P. Robichaud, D. Marion et al., Reduction of Cognitive and Motor Deficits After Traumatic Brain Injury in Mice Deficient in Poly(ADP-Ribose) Polymerase, Journal of Cerebral Blood Flow & Metabolism, vol.65, pp.835-841, 1999.
DOI : 10.1097/00004647-199908000-00002

Y. Ye, M. Strong, Z. Huang, and J. Beckman, [19] Antibodies that recognize nitrotyrosine, Methods Enzymol, vol.269, pp.201-209, 1996.
DOI : 10.1016/S0076-6879(96)69022-3

J. Zhang, V. Dawson, T. Dawson, and S. Snyder, Nitric oxide activation of poly(ADP-ribose) synthetase in neurotoxicity, Science, vol.263, issue.5147, pp.687-689, 1994.
DOI : 10.1126/science.8080500

J. Zhang, A. Pieper, and S. H. Snyder, Poly(ADP-Ribose) Synthetase Activation: An Early Indicator of Neurotoxic DNA Damage, Journal of Neurochemistry, vol.65, issue.3, pp.1411-1414, 1995.
DOI : 10.1046/j.1471-4159.1995.65031411.x

B. Zingarelli, A. Salzman, and C. Szabo, Genetic Disruption of Poly (ADP-Ribose) Synthetase Inhibits the Expression of P-Selectin and Intercellular Adhesion Molecule-1 in Myocardial Ischemia/Reperfusion Injury, Circulation Research, vol.83, issue.1, pp.85-94, 1998.
DOI : 10.1161/01.RES.83.1.85