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Journal articles
Kainate, a double agent that generates seizures: two decades of progress.
Abstract : Studies using kainate, an excitatory amino acid extracted from a seaweed, have provided major contributions to the understanding of epileptogenesis. Here we review pioneering and more recent studies aimed at determining how kainate generates seizures and, in particular, how inhibition is altered during seizures. We focus on target and subunit-specific effects of kainate on hippocampal pyramidal neurons and interneurons that lead to an excitation of both types of neurons and thus to the parallel increase of glutamatergic and GABAergic spontaneous currents. We propose that kainate excites all its targets, the net consequence depending on the level of activity of the network.
Cited literature [15 references]
https://www.hal.inserm.fr/inserm-00485223
Contributor : Roman Tyzio Connect in order to contact the contributor
Submitted on : Thursday, May 20, 2010 - 12:10:41 PM
Last modification on : Friday, April 16, 2021 - 3:10:03 AM
Long-term archiving on: : Wednesday, November 30, 2016 - 10:37:42 PM
Contributor : Roman Tyzio Connect in order to contact the contributor
Submitted on : Thursday, May 20, 2010 - 12:10:41 PM
Last modification on : Friday, April 16, 2021 - 3:10:03 AM
Long-term archiving on: : Wednesday, November 30, 2016 - 10:37:42 PM