Presynaptic kainate receptors that enhance the release of GABA on CA1 hippocampal interneurons. - Archive ouverte HAL Access content directly
Journal Articles Neuron Year : 2001

Presynaptic kainate receptors that enhance the release of GABA on CA1 hippocampal interneurons.

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Abstract

We report that kainate receptors are present on presynaptic GABAergic terminals contacting interneurons and that their activation increases GABA release. Application of kainate increased the frequency of miniature inhibitory postsynaptic currents recorded in CA1 interneurons. Local applications of glutamate but not of AMPA or NMDA also increased GABA quantal release. Application of kainate as well as synaptically released glutamate reduced the number of failures of GABAergic neurotransmission between interneurons. Thus, activation of presynaptic kainate receptors increases the probability of GABA release at interneuron-interneuron synapses. Glutamate may selectively control the communication between interneurons by increasing their mutual inhibition.
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inserm-00484921 , version 1 (19-05-2010)

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  • HAL Id : inserm-00484921 , version 1
  • PUBMED : 11239438

Cite

Rosa Cossart, Roman Tyzio, Céline Dinocourt, Monique Esclapez, June C. Hirsch, et al.. Presynaptic kainate receptors that enhance the release of GABA on CA1 hippocampal interneurons.. Neuron, 2001, 29 (2), pp.497-508. ⟨inserm-00484921⟩

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