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Presynaptic kainate receptors that enhance the release of GABA on CA1 hippocampal interneurons.

Abstract : We report that kainate receptors are present on presynaptic GABAergic terminals contacting interneurons and that their activation increases GABA release. Application of kainate increased the frequency of miniature inhibitory postsynaptic currents recorded in CA1 interneurons. Local applications of glutamate but not of AMPA or NMDA also increased GABA quantal release. Application of kainate as well as synaptically released glutamate reduced the number of failures of GABAergic neurotransmission between interneurons. Thus, activation of presynaptic kainate receptors increases the probability of GABA release at interneuron-interneuron synapses. Glutamate may selectively control the communication between interneurons by increasing their mutual inhibition.
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https://www.hal.inserm.fr/inserm-00484921
Contributor : Roman Tyzio Connect in order to contact the contributor
Submitted on : Wednesday, May 19, 2010 - 3:02:31 PM
Last modification on : Tuesday, October 19, 2021 - 11:03:43 AM
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  • HAL Id : inserm-00484921, version 1
  • PUBMED : 11239438

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Rosa Cossart, Roman Tyzio, Céline Dinocourt, Monique Esclapez, June C. Hirsch, et al.. Presynaptic kainate receptors that enhance the release of GABA on CA1 hippocampal interneurons.. Neuron, Elsevier, 2001, 29 (2), pp.497-508. ⟨inserm-00484921⟩

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