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Journal articles
Quantal release of glutamate generates pure kainate and mixed AMPA/kainate EPSCs in hippocampal neurons.
Abstract : The relative contribution of kainate receptors to ongoing glutamatergic activity is at present unknown. We report the presence of spontaneous, miniature, and minimal stimulation-evoked excitatory postsynaptic currents (EPSCs) that are mediated solely by kainate receptors (EPSC(kainate)) or by both AMPA and kainate receptors (EPSC(AMPA/kainate)). EPSC(kainate) and EPSC(AMPA/kainate) are selectively enriched in CA1 interneurons and mossy fibers synapses of CA3 pyramidal neurons, respectively. In CA1 interneurons, the decay time constant of EPSC(kainate) (circa 10 ms) is comparable to values obtained in heterologous expression systems. In both hippocampal neurons, the quantal release of glutamate generates kainate receptor-mediated EPSCs that provide as much as half of the total glutamatergic current. Kainate receptors are, therefore, key players of the ongoing glutamatergic transmission in the hippocampus.
Cited literature [22 references]
https://www.hal.inserm.fr/inserm-00484870
Contributor : Roman Tyzio <>
Submitted on : Wednesday, May 19, 2010 - 1:15:55 PM
Last modification on : Thursday, February 7, 2019 - 4:11:52 PM
Long-term archiving on: : Thursday, December 1, 2016 - 12:54:37 AM
Contributor : Roman Tyzio <>
Submitted on : Wednesday, May 19, 2010 - 1:15:55 PM
Last modification on : Thursday, February 7, 2019 - 4:11:52 PM
Long-term archiving on: : Thursday, December 1, 2016 - 12:54:37 AM