Abstract : The relative contribution of kainate receptors to ongoing glutamatergic activity is at present unknown. We report the presence of spontaneous, miniature, and minimal stimulation-evoked excitatory postsynaptic currents (EPSCs) that are mediated solely by kainate receptors (EPSC(kainate)) or by both AMPA and kainate receptors (EPSC(AMPA/kainate)). EPSC(kainate) and EPSC(AMPA/kainate) are selectively enriched in CA1 interneurons and mossy fibers synapses of CA3 pyramidal neurons, respectively. In CA1 interneurons, the decay time constant of EPSC(kainate) (circa 10 ms) is comparable to values obtained in heterologous expression systems. In both hippocampal neurons, the quantal release of glutamate generates kainate receptor-mediated EPSCs that provide as much as half of the total glutamatergic current. Kainate receptors are, therefore, key players of the ongoing glutamatergic transmission in the hippocampus.
http://www.hal.inserm.fr/inserm-00484870
Contributeur : Roman Tyzio
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Soumis le : mercredi 19 mai 2010 - 13:15:55
Dernière modification le : vendredi 2 février 2018 - 01:21:43
Document(s) archivé(s) le : jeudi 1 décembre 2016 - 00:54:37
Rosa Cossart, Jérôme Epsztein, Roman Tyzio, Hélène Becq, June Hirsch, et al.. Quantal release of glutamate generates pure kainate and mixed AMPA/kainate EPSCs in hippocampal neurons.. Neuron, Elsevier, 2002, 35 (1), pp.147-59. 〈inserm-00484870〉
