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Journal articles
Paradoxical anti-epileptic effects of a GluR5 agonist of kainate receptors.
Abstract : Kainate generates in adult hippocampal neurons a seizure but also a massive excitation of interneurons and a dramatic increase of the inhibitory drive that impinges on principal cells. This "overinhibition" is largely mediated by GluR5-containing kainate receptors that are enriched on interneurons. Here, using the neonatal intact hippocampus in vitro and the triple chamber, we first show that this mechanism is fully operative in neonatal neurons. We then report that application to one hippocampus of (RS)-2-amino-3-(5-tert-butyl-3-hydroxy-4-isoxazolyl)propionic acid-a relatively selective agonist of GluR5 containing kainate receptors-depresses the propagation of seizure generated in the opposite hippocampus by a convulsive agent. We conclude that the selective excitation of interneurons by GluR5-containing kainate receptor agonists opens a new therapeutic approach for the epilepsies.
Cited literature [21 references]
https://www.hal.inserm.fr/inserm-00484867
Contributor : Roman Tyzio <>
Submitted on : Wednesday, May 19, 2010 - 1:09:09 PM
Last modification on : Friday, April 16, 2021 - 3:10:03 AM
Long-term archiving on: : Wednesday, November 30, 2016 - 10:30:55 PM
Contributor : Roman Tyzio <>
Submitted on : Wednesday, May 19, 2010 - 1:09:09 PM
Last modification on : Friday, April 16, 2021 - 3:10:03 AM
Long-term archiving on: : Wednesday, November 30, 2016 - 10:30:55 PM
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Khalilov_JNeurophysiol_2002.pd...
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