Excitatory actions of gaba during development: the nature of the nurture.

Yehezkel Ben-Ari 1, *
* Corresponding author
Abstract : In the immature brain, GABA (gamma-aminobutyric acid) is excitatory, and GABA-releasing synapses are formed before glutamatergic contacts in a wide range of species and structures. GABA becomes inhibitory by the delayed expression of a chloride exporter, leading to a negative shift in the reversal potential for choride ions. I propose that this mechanism provides a solution to the problem of how to excite developing neurons to promote growth and synapse formation while avoiding the potentially toxic effects of a mismatch between GABA-mediated inhibition and glutamatergic excitation. As key elements of this cascade are activity dependent, the formation of inhibition adds an element of nurture to the construction of cortical networks.
Document type :
Journal articles
Liste complète des métadonnées

Cited literature [110 references]  Display  Hide  Download

Contributor : Roman Tyzio <>
Submitted on : Wednesday, May 19, 2010 - 12:39:40 PM
Last modification on : Monday, January 19, 2015 - 11:49:49 AM
Document(s) archivé(s) le : Wednesday, November 30, 2016 - 10:32:07 PM


 Restricted access
To satisfy the distribution rights of the publisher, the document is embargoed until : jamais

Please log in to resquest access to the document




Yehezkel Ben-Ari. Excitatory actions of gaba during development: the nature of the nurture.. Nature Reviews Neuroscience, Nature Publishing Group, 2002, 3 (9), pp.728-39. ⟨10.1038/nrn920⟩. ⟨inserm-00484852⟩



Record views