Population pharmacokinetics of the humanised monoclonal antibody, HuHMFG1 (AS1402), derived from a phase I study on breast cancer.

Bernard Royer 1, 2, 3 W. Yin 4 M. Pegram 5 Nada Ibrahim 6 Christian Villanueva 7 D. Mir 4 F. Erlandsson 4 Xavier Pivot 2, 7
1 Service de Pharmacologie, toxicologie et pharmacovigilance [CHU Limoges]
2 HOTE GREFFON - Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098)
3 CICB - Centre d'Investigation Clinique de Besançon
4 Antisoma Research Limited
5 University of Miami Miller School of Medicine
6 MD Anderson Cancer Center [Houston]
7 Service d'oncologie Médicale
Abstract : BACKGROUND: HuHMFG1 (AS1402) is a humanised monoclonal antibody that has undergone a phase I trial in metastatic breast cancer. The aim of this study was to characterise the pharmacokinetics (PKs) of HuHMFG1 using a population PK model. METHOD: Data were derived from a phase I study of 26 patients receiving HuHMFG1 at doses ranging from 1 to 16 mg kg(-1). Data were analysed using NONMEM software and covariates were included. A limited sampling strategy (LSS) was developed using training and a validation data set. RESULTS: A linear two-compartment model was shown to be adequate to describe data. Covariate analysis indicated that weight was not related to clearance. An LSS was successfully developed on the basis of the model, in which one sample is collected immediately before the start of an infusion and the second is taken at the end of infusion. CONCLUSION: A two-compartment population PK model successfully describes HuHMFG1 behaviour. The model suggests using a fixed dose of HuHMFG1, which would simplify dosing. The model could be used to optimise dose level and dosing schedule if more data on the correlation between exposure and efficacy become available from future studies. The derived LSS could optimise further PK assessment of this antibody.
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Article dans une revue
British Journal of Cancer, Cancer Research UK, 2010, 102 (5), pp.827-32. 〈10.1038/sj.bjc.6605560〉
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http://www.hal.inserm.fr/inserm-00484827
Contributeur : Philippe Saas <>
Soumis le : mercredi 19 mai 2010 - 11:56:02
Dernière modification le : lundi 9 juillet 2018 - 13:12:02

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Bernard Royer, W. Yin, M. Pegram, Nada Ibrahim, Christian Villanueva, et al.. Population pharmacokinetics of the humanised monoclonal antibody, HuHMFG1 (AS1402), derived from a phase I study on breast cancer.. British Journal of Cancer, Cancer Research UK, 2010, 102 (5), pp.827-32. 〈10.1038/sj.bjc.6605560〉. 〈inserm-00484827〉

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