L. Baez, N. Eskridge, and R. Schein, Postnatal development of dopaminergic and cholinergic catalepsy in the rat, European Journal of Pharmacology, vol.36, issue.1, pp.155-162, 1976.
DOI : 10.1016/0014-2999(76)90267-3

M. Banks and R. Pearce, Kinetic differences between synaptic and extrasynaptic GABA A receptors in CA1 pyramidal cells, J Neurosci, vol.20, pp.937-948, 2000.

V. Bouilleret, B. Schwaller, S. Schurmans, M. Celio, and J. Fritschy, Neurodegenerative and morphogenic changes in a mouse model of temporal lobe epilepsy do not depend on the expression of the calcium-binding proteins parvalbumin, calbindin, or calretinin, Neuroscience, vol.97, issue.1, pp.47-58, 2000.
DOI : 10.1016/S0306-4522(00)00017-8

S. Brickley, S. Cull-candy, and M. Farrant, Development of a tonic form of synaptic inhibition in rat cerebellar granule cells resulting from persistent activation of GABAA receptors., The Journal of Physiology, vol.497, issue.3, pp.753-759, 1996.
DOI : 10.1113/jphysiol.1996.sp021806

S. Brickley, S. Cull-candy, and M. Farrant, Single-channel properties of synaptic and extrasynaptic GABA A receptors suggest differential targeting of receptor subtypes, J Neurosci, vol.19, pp.2960-2973, 1999.

A. Brooks-kayal, M. Shumate, H. Jin, T. Rikhter, and D. Coulter, Selective changes in single cell GABAA receptor subunit expression and function in temporal lobe epilepsy, Nature Medicine, vol.70, issue.10, pp.1166-1172, 1998.
DOI : 10.1016/0306-4522(95)00348-M

I. Brünig, E. Scotti, C. Sidler, and J. Fritschy, Intact sorting, targeting, and clustering of ??-aminobutyric acid A receptor subtypes in hippocampal neurons in vitro, Journal of Comparative Neurology, vol.9, issue.1, pp.43-55, 2002.
DOI : 10.1002/cne.10102

P. Buckmaster and F. Dudek, Neuron loss, granule cell axon reorganization, and functional changes in the dentate gyrus of epileptic kainate???treated rats, The Journal of Comparative Neurology, vol.385, issue.3, pp.385-404, 1997.
DOI : 10.1002/(SICI)1096-9861(19970901)385:3<385::AID-CNE4>3.3.CO;2-Y

E. Buhl, T. Otis, and I. Mody, Zinc-Induced Collapse of Augmented Inhibition by GABA in a Temporal Lobe Epilepsy Model, Science, vol.271, issue.5247, pp.369-373, 1996.
DOI : 10.1126/science.271.5247.369

E. Burgard, E. Tietz, T. Neelands, and R. Macdonald, Properties of recombinant gamma-aminobutyric acid A receptor isoforms containing the 5 subunit subtype, Mol Pharmacol, vol.50, pp.119-127, 1996.

E. Cavalheiro, D. Silva, W. Turski, L. Calderazzo-filho, Z. Bortolotto et al., The susceptibility of rats to pilocarpine-induced seizures is age-dependent, Developmental Brain Research, vol.37, issue.1-2, pp.43-58, 1987.
DOI : 10.1016/0165-3806(87)90227-6

E. Cavalheiro, J. Leite, Z. Bortolotto, W. Turski, C. Ikonomidou et al., Long-Term Effects of Pilocarpine in Rats: Structural Damage of the Brain Triggers Kindling and Spontaneous I Recurrent Seizures, Epilepsia, vol.4, issue.6, pp.778-782, 1991.
DOI : 10.1002/syn.890030207

N. Collinson, F. Kuenzi, W. Jarolimek, K. Maubach, R. Cothliff et al., Enhanced learning and memory and altered GABAergic synaptic transmission in mice lacking the 5 subunit of the GABA A receptor, J Neurosci, vol.22, pp.5572-5580, 2002.

R. Cossart, C. Cinocourt, J. Hirsch, A. Merchan-perez, J. Defelipe et al., Dendritic but not somatic GABAergic inhibition is decreased in experimental epilepsy, Nature Neurosci, vol.4, pp.52-62, 2001.
URL : https://hal.archives-ouvertes.fr/inserm-00484880

D. Coulter and R. Delorenzo, Basic mechanisms of status epilepticus, Adv Neurol, vol.79, pp.725-733, 1999.

F. Crestani, R. Keist, J. Fritschy, D. Benke, K. Vogt et al., Trace fear conditioning involves hippocampal ??5 GABAA receptors, Proceedings of the National Academy of Sciences, vol.99, issue.13, pp.8980-8985, 2002.
DOI : 10.1073/pnas.142288699

M. During, K. Ryder, and D. Spencer, Hippocampal GABA transporter function in temporal-lobe epilepsy, Nature, vol.376, issue.6536, pp.174-177, 1995.
DOI : 10.1038/376174a0

M. Esclapez and C. Houser, Up-regulation of GAD65 and GAD67 in remaining hippocampal GABA neurons in a model of temporal lobe epilepsy, The Journal of Comparative Neurology, vol.15, issue.3, pp.488-505, 1999.
DOI : 10.1002/(SICI)1096-9861(19990927)412:3<488::AID-CNE8>3.0.CO;2-6

URL : https://hal.archives-ouvertes.fr/inserm-00487289

M. Esclapez, N. Tillakaratne, A. Tobin, and C. Houser, Comparative localization of mRNAs encoding two forms of glutamic acid decarboxylase with nonradioactive in situ hybridization methods, The Journal of Comparative Neurology, vol.8, issue.3, pp.339-362, 1993.
DOI : 10.1002/cne.903310305

M. Esclapez, J. Hirsch, Y. Ben-ari, and C. Bernard, Newly formed excitatory pathways provide a substrate for hyperexcitability in experimental temporal lobe epilepsy, The Journal of Comparative Neurology, vol.851, issue.4, pp.449-460, 1999.
DOI : 10.1002/(SICI)1096-9861(19990614)408:4<449::AID-CNE1>3.0.CO;2-R

T. Freund and G. Buzsaki, Interneurons of the hippocampus, Hippocampus, vol.495, issue.1, pp.347-470, 1996.
DOI : 10.1002/(SICI)1098-1063(1996)6:4<347::AID-HIPO1>3.0.CO;2-I

URL : https://hal.archives-ouvertes.fr/inserm-00484796

J. Fritschy and H. Mohler, GABAA-receptor heterogeneity in the adult rat brain: Differential regional and cellular distribution of seven major subunits, The Journal of Comparative Neurology, vol.127, issue.1, pp.154-194, 1995.
DOI : 10.1002/cne.903590111

J. Fritschy, D. Johnson, H. Mohler, and U. Rudolph, Independent assembly and subcellular targeting of GABAA-receptor subtypes demonstrated in mouse hippocampal and olfactory neurons in vivo, Neuroscience Letters, vol.249, issue.2-3, pp.99-102, 1998.
DOI : 10.1016/S0304-3940(98)00397-8

J. Fritschy, T. Kiener, V. Bouilleret, and F. Loup, GABAergic neurons and GABAA-receptors in temporal lobe epilepsy, Neurochemistry International, vol.34, issue.5, pp.435-445, 1999.
DOI : 10.1016/S0197-0186(99)00040-6

J. Gibbs, M. Shumate, and D. Coulter, Differential epilepsy-associated alterations in postsynaptic GABA A receptor function in dentate granule and CA1 neurons, J Neurophysiol, vol.77, pp.1924-1938, 1997.

C. Houser and M. Esclapez, Vulnerability and plasticity of the GABA system in the pilocarpine model of spontaneous recurrent seizures, Epilepsy Research, vol.26, issue.1, pp.207-218, 1996.
DOI : 10.1016/S0920-1211(96)00054-X

C. Houser, M. Esclapez, J. Fritschy, and H. Mohler, Decreased expression of the 5 subunit of the GABA-A receptor in a model of temporal lobe epilepsy, Soc Neurosci Abs, vol.21, p.1475, 1995.

F. Impagnatiello, C. Pesold, P. Longone, H. Caruncho, J. Fritschy et al., Modifications of -aminobutyric acid A receptor subunit expression in rat neocortex during tolerance to diazepam, Mol Pharmacol, vol.49, pp.822-831, 1996.

W. Kamphuis, T. Derijk, and F. Lopes-da-silva, Expression of GABAA receptor subunit mRNAs in hippocampal pyramidal and granular neurons in the kindling model of epileptogenesis: an in situ hybridization study, Molecular Brain Research, vol.31, issue.1-2, pp.33-47, 1995.
DOI : 10.1016/0169-328X(95)00022-K

M. Khrestchatisky, A. Maclennan, M. Chiang, W. Xu, M. Jackson et al., A novel ?? subunit in rat brain GABAA receptors, Neuron, vol.3, issue.6, pp.745-753, 1989.
DOI : 10.1016/0896-6273(89)90243-2

M. Li, A. Szabo, and H. Rosenberg, Down-regulation of benzodiazepine binding to 5 subunit-containing -aminobutyric acid A receptors in tolerant rat brain indicates particular involvement of the hippocampal CA1 region, J Pharmacol Exp Ther, vol.295, pp.689-696, 2000.

Z. Liu, T. Nagao, G. Desjardins, P. Gloor, and M. Avoli, Quantitative evaluation of neuronal loss in the dorsal hippocampus in rats with long-term pilocarpine seizures, Epilepsy Res, vol.17, pp.237-247, 1994.

W. Lu and S. Haber, In situ hybridization histochemistry: a new method for processing material stored for several years, Brain Research, vol.578, issue.1-2, pp.155-160, 1992.
DOI : 10.1016/0006-8993(92)90243-3

P. Malherbe, E. Sigel, R. Baur, E. Persohn, J. Richards et al., receptor in rat brain, FEBS Letters, vol.14, issue.2, pp.261-265, 1990.
DOI : 10.1016/0014-5793(90)80118-3

R. Mckernan, K. Quirk, R. Prince, P. Cox, N. Gillard et al., GABAA receptor subtypes immunopurified from rat brain with ?? subunit-specific antibodies have unique pharmacological properties, Neuron, vol.7, issue.4, pp.667-676, 1991.
DOI : 10.1016/0896-6273(91)90379-E

S. Mertens, D. Benke, and H. Mohler, GABA-A receptor populations with novel subunit combinations and drug binding profiles identified in brain by 5-and -subunit-specific immunopurification, J Biol Chem, vol.268, pp.5965-5973, 1993.

I. Mody, Distinguishing between GABA A receptors responsible for tonic and phasic conductances, Neurochemical Research, vol.26, issue.8/9, pp.907-913, 2001.
DOI : 10.1023/A:1012376215967

Z. Nusser and I. Mody, Selective modulation of tonic and phasic inhibitions in dentate gyrus granule cells, J Neurophysiol, vol.87, pp.2624-2628, 2002.

Z. Nusser, N. Hájos, P. Somogyi, and I. Mody, Increased number of synaptic GABA A receptors underlies potentiation at hippocampal inhibitory synapses, Nature, vol.395, issue.6698, pp.172-177, 1998.
DOI : 10.1038/25999

Z. Nusser, W. Sieghart, and P. Somogyi, Segregation of different GABA A receptors to synaptic and extrasynaptic membranes of cerebellar granule cells, J Comp Neurol, vol.18, pp.1693-1703, 1998.

G. Nyíri, T. Freund, P. Somogyi, . Houser, A. Obenaus et al., receptors in synapses of hippocampal pyramidal cells of the rat, European Journal of Neuroscience, vol.127, issue.3, pp.428-4424470, 1993.
DOI : 10.1046/j.1460-9568.2000.00915.x

O. Donovan, M. Buckland, P. Spurlock, G. Mcguffin, and P. , Bi-directional changes in the levels of messenger RNAs encoding ??-aminobutyric acidA receptor ?? subunits after flurazepam treatment, European Journal of Pharmacology: Molecular Pharmacology, vol.226, issue.4, pp.335-341, 1992.
DOI : 10.1016/0922-4106(92)90051-V

R. Olsen, T. Delorey, M. Gordey, and M. Kang, GABA receptor function and epilepsy, Adv Neurol, vol.79, pp.499-510, 1999.

T. Otis, K. Staley, and I. Mody, Perpetual inhibitory activity in mammalian brain slices generated by spontaneous GABA release, Brain Research, vol.545, issue.1-2, pp.142-150, 1991.
DOI : 10.1016/0006-8993(91)91280-E

Z. Peng, R. Olsen, and C. Houser, Altered expression of the delta subunit of the GABA A receptor in the dentate gyrus in a mouse model of temporal lobe epilepsy. Program No. 433.1 Abstract Viewer/ Itinerary Planner, CD-ROM, 2002.

S. Pirker, C. Schwarzer, A. Wieselthaler, W. Sieghart, and G. Sperk, GABAA receptors: immunocytochemical distribution of 13 subunits in the adult rat brain, Neuroscience, vol.101, issue.4, pp.815-850, 2000.
DOI : 10.1016/S0306-4522(00)00442-5

D. Pritchett and P. Seeburg, -Subunit Creates Novel Type II Benzodiazepine Receptor Pharmacology, Journal of Neurochemistry, vol.216, issue.5, pp.1802-1804, 1990.
DOI : 10.1016/0076-6879(87)53044-0

URL : https://hal.archives-ouvertes.fr/hal-00154733

A. Rice, A. Rafiq, S. Shapiro, E. Jakoi, D. Coulter et al., Long-lasting reduction of inhibitory function and gamma-aminobutyric acid type A receptor subunit mRNA expression in a model of temporal lobe epilepsy., Proceedings of the National Academy of Sciences, vol.93, issue.18, pp.9665-9669, 1996.
DOI : 10.1073/pnas.93.18.9665

D. Rossi and M. Hamann, Spillover-Mediated Transmission at Inhibitory Synapses Promoted by High Affinity ??6 Subunit GABAA Receptors and Glomerular Geometry, Neuron, vol.20, issue.4, pp.783-795, 1998.
DOI : 10.1016/S0896-6273(00)81016-8

P. Rutecki, R. Grossman, D. Armstrong, and S. Irish-loewen, Electrophysiological connections between the hippocampus and entorhinal cortex in patients with complex partial seizures, Journal of Neurosurgery, vol.70, issue.5, pp.667-675, 1989.
DOI : 10.3171/jns.1989.70.5.0667

C. Schwarzer, K. Tsunashima, C. Wanzenbock, K. Fuchs, W. Sieghart et al., GABAA receptor subunits in the rat hippocampus II: Altered distribution in kainic acid-induced temporal lobe epilepsy, Neuroscience, vol.80, issue.4, pp.1001-1017, 1997.
DOI : 10.1016/S0306-4522(97)00145-0

R. Sloviter, Decreased hippocampal inhibition and a selective loss of interneurons in experimental epilepsy, Science, vol.235, issue.4784, pp.73-76, 1987.
DOI : 10.1126/science.2879352

B. Smith and F. Dudek, Network interactions mediated by new excitatory connections between CA1 pyramidal cells in rats with kainateinduced epilepsy, J Neurophysiol, vol.87, pp.1655-1658, 2002.

P. Somogyi, J. Fritschy, D. Benke, J. Roberts, and W. Sieghart, The ??2 Subunit of the GABAA Receptor is Concentrated in Synaptic Junctions Containing the ??1 and ?? Subunits in Hippocampus, Cerebellum and Globus Pallidus, Neuropharmacology, vol.35, issue.9-10, pp.1425-1444, 1996.
DOI : 10.1016/S0028-3908(96)00086-X

G. Sperk, J. Marksteiner, B. Gruber, R. Bellmann, M. Mahata et al., Functional changes in neuropeptide Y- and somatostatin-containing neurons induced by limbic seizures in the rat, Neuroscience, vol.50, issue.4, pp.831-846, 1992.
DOI : 10.1016/0306-4522(92)90207-I

G. Sperk, C. Schwarzer, K. Tsunashima, J. Fuchs, and W. Sieghart, GABAA receptor subunits in the rat hippocampus I: Immunocytochemical distribution of 13 subunits, Neuroscience, vol.80, issue.4, pp.987-1000, 1997.
DOI : 10.1016/S0306-4522(97)00146-2

A. Thomson, A. Bannister, D. Hughes, and H. Pawelzik, Differential sensitivity to Zolpidem of IPSPs activated by morphologically identified CA1 interneurons in slices of rat hippocampus, European Journal of Neuroscience, vol.510, issue.2, pp.425-436, 2000.
DOI : 10.1046/j.1460-9568.2000.00915.x

E. Tietz, X. Huang, X. Weng, H. Rosenberg, and T. Chiu, Expression of ??1, ??5, and ??2 GABAA receptor subunit mRNAs measuredIn Situ in rat hippocampus and cortex following chronic flurazepam administration, Journal of Molecular Neuroscience, vol.45, issue.4, pp.277-292, 1994.
DOI : 10.1007/BF02821559

E. Tietz, X. Huang, S. Chen, and W. Ferencak, Temporal and regional regulation of ??1, ??2 and ??3, but not ??2, ??4, ??5, ??6, ??1 or ??2 GABAA receptor subunit messenger RNAs following one-week oral flurazepam administration, Neuroscience, vol.91, issue.1, pp.327-341, 2002.
DOI : 10.1016/S0306-4522(98)00516-8

K. Tsunashima, C. Schwarzer, E. Kirchmair, W. Sieghart, and G. Sperk, GABAA receptor subunits in the rat hippocampus III: altered messenger RNA expression in kainic acid-induced epilepsy, Neuroscience, vol.80, issue.4, pp.1019-1032, 1997.
DOI : 10.1016/S0306-4522(97)00144-9

W. Turski, E. Cavalheiro, M. Schwarz, S. Czuczwar, Z. Kleinrok et al., Limbic seizures produced by pilocarpine in rats: Behavioural, electroencephalographic and neuropathological study, Behavioural Brain Research, vol.9, issue.3, pp.315-336, 1983.
DOI : 10.1016/0166-4328(83)90136-5

W. Wei, I. Mody, N. Zhang, Z. Peng, and C. Houser, Overspill dependent activation and anatomical localization of subunit containing GABA A receptors in the mouse dentate gyrus. Program No. 148.6 Abstract Viewer/Itinerary Planner, CD-ROM, 2002.

W. Wisden, D. Laurie, M. Monyer, and P. Seeburg, The distribution of 13 GABA A receptor subunit mRNAs in the rat brain. I. Telencephalon , diencephalon, mesencephalon, J Neurosci, vol.12, pp.1040-1062, 1992.

T. Zhao, T. Chiu, and H. Rosenberg, Reduced expression of -aminobutyric acid type A/benzodiazepine receptor 2 and 5 subunit mRNAs in brain regions of flurazepam-treated rats, Mol Pharmacol, vol.45, pp.657-663, 1994.