[Kappa light chain deposition disease, presenting as Sjögren's syndrome, successfully treated by high-dose melphalan and autologous blood stem transplantation]

C. Foguem; Bernadette Kantelip; Eric Deconinck; Chafika Hafsaoui; Nadine Méaux-Ruault; Helder Gil; Nadine Magy-Bertrand; Jean-Louis Dupond

doi:10.1016/j.revmed.2008.08.003

Journal articles

[Kappa light chain deposition disease, presenting as Sjögren's syndrome, successfully treated by high-dose melphalan and autologous blood stem transplantation]

C. Foguem ^{1, 2} Bernadette Kantelip ^{1, 3} Eric Deconinck ^{1, 4} Chafika Hafsaoui ^{1, 2} Nadine Méaux-Ruault ^{1, 2} Helder Gil ^{1, 2} Nadine Magy-Bertrand ^{1, 2} Jean-Louis Dupond ^{1, 2}

1 Service d'hématologie

2 Service d'oncologie Médicale

3 Laboratoire d'anatomie pathologique [Besancon]

4 HOTE GREFFON - Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098)

Abstract : INTRODUCTION: Light chain deposition disease is a systemic disorder characterised by tissue deposition of monoclonal immunoglobulin light chains without tinctorial properties. It has been exceptionally reported with salivary involvement mimicking Sjögren's syndrome and peripheral neuropathy. CASE REPORT: We report a case of light chain deposition disease associated with plasma cell dyscrasia presenting as sicca syndrome with salivary glands hypertrophy and polyneuropathy successfully treated by high dose melphalan and autologous blood stem transplantation. CONCLUSION: Light chain deposition disease should be recognized as an aetiology of sicca syndrome and peripheral neuropathy. Further studies should assess the prevalence of sicca syndrome in light chain deposition disease and better characterise the neurological manifestations.

Document type :

Journal articles

Domain :

Life Sciences [q-bio] / Immunology

Complete list of metadatas

https://www.hal.inserm.fr/inserm-00484589
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Submitted on : Tuesday, May 18, 2010 - 4:08:56 PM
Last modification on : Wednesday, September 16, 2020 - 10:43:29 AM

[Kappa light chain deposition disease, presenting as Sjögren's syndrome, successfully treated by high-dose melphalan and autologous blood stem transplantation]

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[Kappa light chain deposition disease, presenting as Sjögren's syndrome, successfully treated by high-dose melphalan and autologous blood stem transplantation]

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