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Journal articles
High-dose therapy followed by autologous purged stem cell transplantation and doxorubicin-based chemotherapy in patients with advanced follicular lymphoma: a randomized multicenter study by the GOELAMS with final results after a median follow-up of 9 years.
Emmanuel Gyan
1
Charles Foussard
2
Philippe Bertrand
3
Patrick Michenet
4
Steven Le Gouill
5
Christian Berthou
6
Hervé Maisonneuve
7
Vincent Delwail
8
Rémi Gressin
9
Philippe Quittet
10
Jean-Pierre Vilque
11
Bernard Desablens
12
Jérôme Jaubert
13
Jean-François Ramée
14
Nina Arakelyan
15
Antoine Thyss
16
Cécile Moluçon-Chabrot
17
Roselyne Delépine
1
Noël Milpied
18
Philippe Colombat
1
Eric Deconinck
19
Emmanuel Gyan 1
Author
Charles Foussard 2
Author
Philippe Bertrand 3
Author
Patrick Michenet 4
Author
Steven Le Gouill 5
Author
Christian C. Berthou 6
Author
Hervé Maisonneuve 7
Author
Vincent Delwail 8
Author
Rémi Gressin 9
Author
Philippe Quittet 10
Author
Jean-Pierre Vilque 11
Author
Bernard Desablens 12
Author
Jérôme Jaubert 13
Author
Jean-François Ramée 14
Author
Nina Arakelyan 15
Author
Antoine Thyss 16
Author
Cécile Moluçon-Chabrot 17
Author
Roselyne Delépine 1
Author
Noël N. Milpied 18
Author
Philippe Colombat 1
Author
Eric Deconinck 19
Author
1
Service d'hématologie [Tours] (France)
2
Service d'hématologie (Angers - France)
- CHU Angers - Centre Hospitalier Universitaire d'Angers (4 rue Larrey - 49933 Angers cedex 9 - France)
- Hôtel Dieu (France)
5
Service d'hématologie (France)
6
Service d'hématologie (France)
8
Service Hématologie (2 rue de la Milétrie 86000 Poitiers - France)
- CHU Poitiers - Centre hospitalier universitaire de Poitiers (2 Rue de la Milétrie, 86021 Poitiers - France)
- Hôpital Jean Bernard (France)
10
Service d'hématologie (France)
- CHRU Montpellier - Centre Hospitalier Régional Universitaire [Montpellier] (191 avenue du doyen Gaston Giraud 34295 Montpellier cedex 5 - France)
11
UNICANCER/CRLC - Centre Régional de Lutte contre le Cancer François Baclesse [Caen] (3 avenue général Harris, 14000 Caen - France)
- UNICANCER (101, rue de Tolbiac, 75654 Paris Cedex 13 - France)
- TCBN - Tumorothèque de Caen Basse-Normandie (3 avenue du Général Harris 14076 Caen cedex 5 - France)
- NU - Normandie Université (Esplanade de la Paix - CS 14032 - 14032 Caen Cedex 5 - France)
12
Laboratoire d'Hématologie (Avenue René Laënnec 80054 Amiens cedex 1 - France)
- CHU Amiens-Picardie (France)
- Hôpital Sud (France)
15
Service d'hématologie (Paris - France)
- AP-HP - Assistance publique - Hôpitaux de Paris (AP-HP) (France)
- HEGP - Hôpital Européen Georges Pompidou [APHP] (20, rue Leblanc, 75015 Paris - France)
16
UNICANCER/CAL - Centre de Lutte contre le Cancer Antoine Lacassagne [Nice] (33, avenue de Valombrose, 06189 Nice - France)
- UNICANCER (101, rue de Tolbiac, 75654 Paris Cedex 13 - France)
- UCA - Université Côte d'Azur (Parc Valrose, 28 avenue Valrose 06108 Nice Cedex 2 - France)
18
Service d'hématologie (France)
- CHU Bordeaux [Bordeaux] (place Amélie Raba Léon 33076 BORDEAUX CEDEX - France)
19
RIGHT - Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098) (I.B.C.T.
Bâtiment Inserm
240 Route de Dole/Rue F. Dolto
25000 Besançon - France)
- INSERM - Institut National de la Santé et de la Recherche Médicale : U1098 (101, rue de Tolbiac, 75013 Paris - France)
- EFS [Bourgogne-Franche-Comté] - Etablissement français du sang [Bourgogne-Franche-Comté] (1 Boulevard Fleming 25020 Besançon cedex - France)
- UFC - Université de Franche-Comté (1 rue Goudimel 25030 Besançon cedex - France)
Abstract : Autologous stem cell transplantation (ASCT) as first-line therapy for follicular lymphoma (FL) remains controversial. The multicenter study randomized 172 patients with untreated FL for either immunochemotherapy or high-dose therapy (HDT) followed by purged ASCT. Conditioning was performed with total body irradiation (TBI) and cyclophosphamide. The 9-year overall survival (OS) was similar in the HDT and conventional chemotherapy groups (76% and 80%, respectively). The 9-year progression-free survival (PFS) was higher in the ASCT than the chemotherapy group (64% vs 39%; P = .004). A PFS plateau was observed in the HDT group after 7 years. On multivariate analysis, OS and PFS were independently affected by the per-formance status score, the number of nodal areas involved, and the treatment group. Secondary malignancies were more frequent in the HDT than in the chemotherapy group (6 secondary myelodysplastic syndrome/acute myeloid leukemia and 6 second solid tumor cancers vs 1 acute myeloid leukemia, P = .01). The occurrence of a PFS plateau suggests that a subgroup of patients might have their FL cured by ASCT. However, the increased rate of secondary malignancies may discourage the use of purged ASCT in combination with TBI as first-line treatment for FL. This trial has been registered with ClinicalTrials.gov under identifier NCT00696735.
Document type :
Journal articles
Domain :
Complete list of metadatas
https://www.hal.inserm.fr/inserm-00484585
Contributor : Philippe Saas <>
Submitted on : Tuesday, May 18, 2010 - 4:07:31 PM
Last modification on : Thursday, January 21, 2021 - 2:10:03 PM
Contributor : Philippe Saas <>
Submitted on : Tuesday, May 18, 2010 - 4:07:31 PM
Last modification on : Thursday, January 21, 2021 - 2:10:03 PM
Identifiers
- HAL Id : inserm-00484585, version 1
- DOI : 10.1182/blood-2008-05-160200
- PUBMED : 18955565
Collections
INSERM | UNIV-FCOMTE | UMR645 | UNAM | COMUE-NORMANDIE | UNIV-COTEDAZUR
Citation
Emmanuel Gyan, Charles Foussard, Philippe Bertrand, Patrick Michenet, Steven Le Gouill, et al.. High-dose therapy followed by autologous purged stem cell transplantation and doxorubicin-based chemotherapy in patients with advanced follicular lymphoma: a randomized multicenter study by the GOELAMS with final results after a median follow-up of 9 years.. Blood, American Society of Hematology, 2009, 113 (5), pp.995-1001. ⟨10.1182/blood-2008-05-160200⟩. ⟨inserm-00484585⟩
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