P. Ascher and L. Nowak, The role of divalent cations in the N-methyl-D-aspartate responses of mouse central neurones in culture., The Journal of Physiology, vol.399, issue.1, pp.247-266, 1988.
DOI : 10.1113/jphysiol.1988.sp017078

Y. Ben-ari, Limbic seizure and brain damage produced by kainic acid: Mechanisms and relevance to human temporal lobe epilepsy, Neuroscience, vol.14, issue.2, pp.375-403, 1985.
DOI : 10.1016/0306-4522(85)90299-4

Y. Ben-ari and R. Cossart, Kainate, a double agent that generates seizures: two decades of progress, Trends in Neurosciences, vol.23, issue.11, pp.580-587, 2000.
DOI : 10.1016/S0166-2236(00)01659-3
URL : https://hal.archives-ouvertes.fr/inserm-00485223

Y. Ben-ari and A. Represa, Brief seizure episodes induce long-term potentiation and mossy fibre sprouting in the hippocampus, Trends in Neurosciences, vol.13, issue.8, pp.312-318, 1990.
DOI : 10.1016/0166-2236(90)90135-W

M. Berry and V. Pentreath, Criteria for distinguishing between monosynaptic and polysynaptic transmission, Brain Research, vol.105, issue.1, pp.1-20, 1976.
DOI : 10.1016/0006-8993(76)90919-7

P. Buckmaster and F. Dudek, In vivo intracellular analysis of granule cell axon reorganization in epileptic rats, J Neurophysiol, vol.81, pp.712-721, 1999.

P. Buckmaster, G. Zhang, and R. Yamawaki, Axon sprouting in a model of temporal lobe epilepsy creates a predominantly excitatory feedback circuit, J Neurosci, vol.22, pp.6650-6658, 2002.

I. Bureau, S. Bischoff, S. Heinemann, and C. Mulle, Kainate receptormediated responses in the CA1 field of wild-type and GluR6-deficient mice, J Neurosci, vol.19, pp.653-663, 1999.

P. Castillo, R. Malenka, and R. Nicoll, Kainate receptors mediate a slow postsynaptic current in hippocampal CA3 neurons, Nature, vol.388, pp.182-186, 1997.

R. Cossart, M. Esclapez, J. Hirsch, C. Bernard, and B. Ari, GluR5 kainate receptor activation in interneurons increases tonic inhibition of pyramidal cells, Nature Neuroscience, vol.1, issue.6, pp.470-478, 1998.
DOI : 10.1038/2185
URL : https://hal.archives-ouvertes.fr/inserm-00487305

R. Cossart, J. Epsztein, R. Tyzio, H. Becq, J. Hirsch et al., Quantal Release of Glutamate Generates Pure Kainate and Mixed AMPA/Kainate EPSCs in Hippocampal Neurons, Neuron, vol.35, issue.1, pp.147-159, 2002.
DOI : 10.1016/S0896-6273(02)00753-5
URL : https://hal.archives-ouvertes.fr/inserm-00484870

S. Devries and E. Schwartz, Kainate receptors mediate synaptic transmission between cones and " off " bipolar cells in a mammalian retina, Nature, vol.397, issue.6715, pp.157-160, 1999.
DOI : 10.1038/16462

R. Dingledine, M. Hynes, and G. King, Involvement of N-methyl-D-aspartate receptors in epileptiform bursting in the rat hippocampal slice., The Journal of Physiology, vol.380, issue.1, pp.175-189, 1986.
DOI : 10.1113/jphysiol.1986.sp016279

L. Feng, P. Molnar, and J. Nadler, Short-term frequency-dependent plasticity at recurrent mossy fiber synapses of the epileptic brain, J Neurosci, vol.23, pp.5381-5390, 2003.

J. Franck, J. Pokorny, D. Kunkel, and P. Schwartzkroin, Physiologic and Morphologic Characteristics of Granule Cell Circuitry in Human Epileptic Hippocampus, Epilepsia, vol.10, issue.6, pp.543-558, 1995.
DOI : 10.1016/0006-8993(90)90615-I

J. Fremeau, S. Voglmaier, R. Seal, and R. Edwards, VGLUTs define subsets of excitatory neurons and suggest novel roles for glutamate, Trends in Neurosciences, vol.27, issue.2, pp.98-103, 2004.
DOI : 10.1016/j.tins.2003.11.005

M. Frerking and R. Nicoll, Synaptic kainate receptors, Current Opinion in Neurobiology, vol.10, issue.3, pp.342-351, 2000.
DOI : 10.1016/S0959-4388(00)00094-5

M. Frerking and P. Ohligre-frerking, AMPA receptors and kainate receptors encode different features of afferent activity, J Neurosci, vol.22, pp.7434-7443, 2002.

M. Frerking, R. Malenka, and R. Nicoll, Synaptic activation of kainate receptors on hippocampal interneurons, Nature Neuroscience, vol.1, issue.6, pp.479-486, 1998.
DOI : 10.1038/2194

S. Gabriel, M. Njunting, J. Pomper, M. Merschhemke, E. Sanabria et al., Stimulus and Potassium-Induced Epileptiform Activity in the Human Dentate Gyrus from Patients with and without Hippocampal Sclerosis, Journal of Neuroscience, vol.24, issue.46, pp.10416-10430, 2004.
DOI : 10.1523/JNEUROSCI.2074-04.2004

J. Gaiarsa, L. Zagrean, B. Ari, and Y. , Neonatal irradiation prevents the formation of hippocampal mossy fibers and the epileptic action of kainate on rat CA3 pyramidal neurons, J Neurophysiol, vol.71, pp.204-215, 1994.

J. Hardison, M. Okazaki, and J. Nadler, Modest increase in extracellular potassium unmasks effect of recurrent mossy fiber growth, J Neurophysiol, vol.84, pp.2380-2389, 2000.

D. Henze, N. Urban, and G. Barrionuevo, The multifarious hippocampal mossy fiber pathway: a review, Neuroscience, vol.98, issue.3, pp.407-427, 2000.
DOI : 10.1016/S0306-4522(00)00146-9

J. Huettner, Kainate receptors and synaptic transmission, Progress in Neurobiology, vol.70, issue.5, pp.387-407, 2003.
DOI : 10.1016/S0301-0082(03)00122-9

M. Isokawa, M. Levesque, T. Babb, and J. Engel, Single mossy fiber axonal systems of human dentate granule cells studied in hippocampal slices from patients with temporal-lobe epilepsy, J Neurosci, vol.13, pp.1511-1522, 1993.

H. Kamiya, H. Shinozaki, and C. Yamamoto, Activation of metabotropic glutamate receptor type 2/3 suppresses transmission at rat hippocampal mossy fibre synapses., The Journal of Physiology, vol.493, issue.2, pp.447-455, 1996.
DOI : 10.1113/jphysiol.1996.sp021395

C. Leranth, Z. Szeidemann, M. Hsu, and G. Buzsaki, AMPA receptors in the rat and primate hippocampus: a possible absence of GLUR2/3 subunits in most interneurons, Neuroscience, vol.70, issue.3, pp.631-652, 1996.
DOI : 10.1016/S0306-4522(96)83003-X

J. Lerma, Roles and rules of kainate receptors in synaptic transmission, Nature Reviews Neuroscience, vol.4, issue.6, pp.481-495, 2003.
DOI : 10.1038/nrn1118

H. Li and M. Rogawski, GluR5 kainate receptor mediated synaptic transmission in rat basolateral amygdala in vitro, Neuropharmacology, vol.37, issue.10-11, pp.1279-1286, 1998.
DOI : 10.1016/S0028-3908(98)00109-9

P. Li, T. Wilding, S. Kim, A. Calejesan, J. Huettner et al., Kainate-receptor-mediated sensory synaptic transmission in mammalian spinal cord, Nature, vol.397, pp.161-164, 1999.

M. Lynch and T. Sutula, Recurrent excitatory connectivity in the dentate gyrus of kindled and kainic acid-treated rats, J Neurophysiol, vol.83, pp.693-704, 2000.

C. Marchal and C. Mulle, Postnatal maturation of mossy fibre excitatory transmission in mouse CA3 pyramidal cells: a potential role for kainate receptors, The Journal of Physiology, vol.14, issue.1, pp.27-37, 2004.
DOI : 10.1113/jphysiol.2004.069922

L. Mello, E. Cavalheiro, A. Tan, W. Kupfer, J. Pretorius et al., Circuit Mechanisms of Seizures in the Pilocarpine Model of Chronic Epilepsy: Cell Loss and Mossy Fiber Sprouting, Epilepsia, vol.200, issue.6, pp.985-995, 1993.
DOI : 10.1002/syn.890030207

P. Molnar and J. Nadler, Mossy fiber-granule cell synapses in the normal and epileptic rat dentate gyrus studied with minimal laser photostimulation, J Neurophysiol, vol.82, pp.1883-1894, 1999.

D. Monaghan and C. Cotman, The distribution of [3H]kainic acid binding sites in rat CNS as determined by autoradiography, Brain Research, vol.252, issue.1, pp.91-100, 1982.
DOI : 10.1016/0006-8993(82)90981-7

C. Mulle, A. Sailer, I. Perez-otano, H. Dickinson-anson, P. Castillo et al., Altered synaptic physiology and reduced susceptibility to kainate-induced seizures in GluR6-deficient mice, Nature, vol.392, pp.601-605, 1998.

J. Nadler, The recurrent mossy fiber pathway of the epileptic brain, Neurochemical Research, vol.28, issue.11, pp.1649-1658, 2003.
DOI : 10.1023/A:1026004904199

M. Okazaki and J. Nadler, Glutamate receptor involvement in dentate granule cell epileptiform activity evoked by mossy fiber stimulation, Brain Research, vol.915, issue.1, pp.58-69, 2001.
DOI : 10.1016/S0006-8993(01)02824-4

M. Okazaki, D. Evenson, and J. Nadler, Hippocampal mossy fiber sprouting and synapse formation after status epilepticus in rats: Visualization after retrograde transport of biocytin, The Journal of Comparative Neurology, vol.76, issue.4, pp.515-534, 1995.
DOI : 10.1002/cne.903520404

P. Patrylo and F. Dudek, Physiological unmasking of new glutamatergic pathways in the dentate gyrus of hippocampal slices from kainateinduced epileptic rats, J Neurophysiol, vol.79, pp.418-429, 1998.

R. Racine, Modification of seizure activity by electrical stimulation: II. Motor seizure, Electroencephalography and Clinical Neurophysiology, vol.32, issue.3, pp.281-294, 1972.
DOI : 10.1016/0013-4694(72)90177-0

A. Represa, E. Tremblay, B. Ari, and Y. , Kainate binding sites in the hippocampal mossy fibers: Localization and plasticity, Neuroscience, vol.20, issue.3, pp.739-748, 1987.
DOI : 10.1016/0306-4522(87)90237-5

A. Represa, O. Robain, E. Tremblay, B. Ari, and Y. , Hippocampal plasticity in childhood epilepsy, Neuroscience Letters, vol.99, issue.3, pp.351-355, 1989.
DOI : 10.1016/0304-3940(89)90472-2

A. Represa, I. Jorquera, G. Lasalle, B. Ari, and Y. , Epilepsy induced collateral sprouting of hippocampal mossy fibers: Does it induce the development of ectopic synapses with granule cell dendrites?, Hippocampus, vol.5, issue.3, pp.257-268, 1993.
DOI : 10.1002/hipo.450030303

M. Rogawski, D. Gryder, D. Castaneda, W. Yonekawa, M. Banks et al., GluR5 Kainate Receptors, Seizures, and the Amygdala, Annals of the New York Academy of Sciences, vol.29, issue.Suppl 1, pp.150-162, 2003.
DOI : 10.1111/j.1749-6632.2003.tb07079.x

P. Salin, M. Scanziani, R. Malenka, and R. Nicoll, Distinct short-term plasticity at two excitatory synapses in the hippocampus, Proceedings of the National Academy of Sciences, vol.93, issue.23, pp.13304-13309, 1996.
DOI : 10.1073/pnas.93.23.13304

H. Scharfman, K. Smith, J. Goodman, and A. Sollas, Survival of dentate hilar mossy cells after pilocarpine-induced seizures and their synchronized burst discharges with area CA3 pyramidal cells, Neuroscience, vol.104, issue.3, pp.741-759, 2001.
DOI : 10.1016/S0306-4522(01)00132-4

H. Scharfman, A. Sollas, R. Berger, and J. Goodman, Electrophysiological Evidence of Monosynaptic Excitatory Transmission Between Granule Cells After Seizure-Induced Mossy Fiber Sprouting, Journal of Neurophysiology, vol.90, issue.4, pp.2536-2547, 2003.
DOI : 10.1152/jn.00251.2003

D. Schmitz, J. Mellor, and R. Nicoll, Presynaptic Kainate Receptor Mediation of Frequency Facilitation at Hippocampal Mossy Fiber Synapses, Science, vol.291, issue.5510, pp.1972-1976, 2001.
DOI : 10.1126/science.1057105

I. Smolders, Z. Bortolotto, V. Clarke, R. Warre, G. Khan et al., Antagonists of GLU(K5)- containing kainate receptors prevent pilocarpine-induced limbic seizures, Nat Neurosci, vol.5, pp.796-804, 2002.

T. Sutula, X. He, J. Cavazos, and G. Scott, Synaptic reorganization in the hippocampus induced by abnormal functional activity, Science, vol.239, issue.4844, pp.1147-1150, 1988.
DOI : 10.1126/science.2449733

T. Sutula, G. Cascino, J. Cavazos, I. Parada, and L. Ramirez, Mossy fiber synaptic reorganization in the epileptic human temporal lobe, Annals of Neurology, vol.14, issue.3, pp.321-330, 1989.
DOI : 10.1002/ana.410260303

D. Tauck and J. Nadler, Evidence of functional mossy fiber sprouting in hippocampal-formation of kainic acid-treated rats, J Neurosci, vol.5, pp.1016-1022, 1985.

M. Vignes and G. Collingridge, The synaptic activation of kainate receptors, Nature, vol.388, pp.179-182, 1997.
URL : https://hal.archives-ouvertes.fr/hal-00659452

M. Weisskopf, P. Castillo, R. Zalutsky, and R. Nicoll, Mediation of hippocampal mossy fiber long-term potentiation by cyclic AMP, Science, vol.265, issue.5180, pp.1878-1882, 1994.
DOI : 10.1126/science.7916482

J. Wuarin and F. Dudek, Electrographic seizures and new recurrent excitatory circuits in the dentate gyrus of hippocampal slices from kainatetreated epileptic rats, J Neurosci, vol.16, pp.4438-4448, 1996.

J. Wuarin and F. Dudek, Excitatory synaptic input to granule cells increases with time after kainate treatment, J Neurophysiol, vol.85, pp.1067-1077, 2001.