Ixabepilone: a new active chemotherapy in the treatment of breast cancer.

Cristian Villanueva 1 Antoine Thiery Vuillemin 1 Martin Demarchi 1 Fernando Bazan 1 Loïc Chaigneau 1 Xavier Pivot 1, 2
1 Service d'oncologie Médicale
2 HOTE GREFFON - Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098)
Abstract : Ixabepilone (BMS247550) is a semisynthetic derivative of the natural product that optimizes the properties observed with epothilone B. This compound has some similarities with taxanes in targeting and stabilizing microtubules, but it also has major differences. Interestingly, ixabepilone was evaluated in patients with well-characterized resistance to taxanes and was able to overcome the overexpression of multidrug resistance and was unaffected by mutations in the beta-tubulin genes. The interest in ixabepilone was clinically confirmed in Phase II and III clinical studies, which have demonstrated a strong activity in patients with metastatic breast cancer resistant to taxanes and in patients suffering from other types of chemoresistant tumors.
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Article dans une revue
Womens Health (Lond Engl), 2009, 5 (2), pp.115-21. 〈10.2217/17455057.5.2.115〉
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http://www.hal.inserm.fr/inserm-00484429
Contributeur : Philippe Saas <>
Soumis le : mardi 18 mai 2010 - 14:11:08
Dernière modification le : lundi 9 juillet 2018 - 13:12:02

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UNIV-FCOMTE | UMR645

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Cristian Villanueva, Antoine Thiery Vuillemin, Martin Demarchi, Fernando Bazan, Loïc Chaigneau, et al.. Ixabepilone: a new active chemotherapy in the treatment of breast cancer.. Womens Health (Lond Engl), 2009, 5 (2), pp.115-21. 〈10.2217/17455057.5.2.115〉. 〈inserm-00484429〉

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