Service interruption on Monday 11 July from 12:30 to 13:00: all the sites of the CCSD (HAL, Epiciences, SciencesConf, AureHAL) will be inaccessible (network hardware connection).
Skip to Main content Skip to Navigation
Journal articles

Epileptogenic actions of GABA and fast oscillations in the developing hippocampus.

Abstract : GABA excites immature neurons and inhibits adult ones, but whether this contributes to seizures in the developing brain is not known. We now report that in the developing, but not the adult, hippocampus, seizures beget seizures only if GABAergic synapses are functional. In the immature hippocampus, seizures generated with functional GABAergic synapses include fast oscillations that are required to transform a naive network to an epileptic one: blocking GABA receptors prevents the long-lasting sequels of seizures. In contrast, in adult neurons, full blockade of GABA(A) receptors generates epileptogenic high-frequency seizures. Therefore, purely glutamatergic seizures are not epileptogenic in the developing hippocampus. We suggest that the density of glutamatergic synapses is not sufficient for epileptogenesis in immature neurons; excitatory GABAergic synapses are required for that purpose. We suggest that the synergistic actions of GABA and NMDA receptors trigger the cascades involved in epileptogenesis in the developing hippocampus.
Document type :
Journal articles
Complete list of metadata

Cited literature [61 references]  Display  Hide  Download
Contributor : Roman Tyzio Connect in order to contact the contributor
Submitted on : Tuesday, May 18, 2010 - 2:10:43 PM
Last modification on : Wednesday, January 26, 2022 - 3:12:17 AM
Long-term archiving on: : Thursday, December 1, 2016 - 1:49:17 AM


 Restricted access
To satisfy the distribution rights of the publisher, the document is embargoed until : jamais

Please log in to resquest access to the document




Ilgam Khalilov, Michel Le van Quyen, Henri Gozlan, yehezkel Ben-Ari. Epileptogenic actions of GABA and fast oscillations in the developing hippocampus.. Neuron, Elsevier, 2005, 48 (5), pp.787-96. ⟨10.1016/j.neuron.2005.09.026⟩. ⟨inserm-00484426⟩



Record views