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Journal Articles Neuron Year : 2005

Epileptogenic actions of GABA and fast oscillations in the developing hippocampus.

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Abstract

GABA excites immature neurons and inhibits adult ones, but whether this contributes to seizures in the developing brain is not known. We now report that in the developing, but not the adult, hippocampus, seizures beget seizures only if GABAergic synapses are functional. In the immature hippocampus, seizures generated with functional GABAergic synapses include fast oscillations that are required to transform a naive network to an epileptic one: blocking GABA receptors prevents the long-lasting sequels of seizures. In contrast, in adult neurons, full blockade of GABA(A) receptors generates epileptogenic high-frequency seizures. Therefore, purely glutamatergic seizures are not epileptogenic in the developing hippocampus. We suggest that the density of glutamatergic synapses is not sufficient for epileptogenesis in immature neurons; excitatory GABAergic synapses are required for that purpose. We suggest that the synergistic actions of GABA and NMDA receptors trigger the cascades involved in epileptogenesis in the developing hippocampus.
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inserm-00484426 , version 1 (18-05-2010)

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Ilgam Khalilov, Michel Le van Quyen, Henri Gozlan, Yehezkel Ben-Ari. Epileptogenic actions of GABA and fast oscillations in the developing hippocampus.. Neuron, 2005, 48 (5), pp.787-96. ⟨10.1016/j.neuron.2005.09.026⟩. ⟨inserm-00484426⟩
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