Skip to Main content Skip to Navigation
Journal articles

A noncanonical release of GABA and glutamate modulates neuronal migration.

Abstract : Immature neurons express GABA and glutamate receptors before synapse formation, and both transmitters are released at an early developmental stage. We have now tested the hypothesis that the ongoing release of GABA and glutamate modulates neuronal migration. Using 5-bromo-2'-deoxyuridine labeling and cocultures of hippocampal slices obtained from naive and green fluorescent protein-transgenic mice, we report that migration is severely affected by GABA(A) or NMDA receptor antagonist treatments. These effects were also present in munc18-1 knock-out slices in which soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE)-dependent vesicular secretion of transmitters has been deleted. GABA(A) antagonists were more efficient than NMDA antagonists to reduce cell migration, in keeping with the earlier maturation of GABAergic mechanisms. We conclude that GABA and, to a lesser degree, glutamate released in a SNARE-independent mechanism exert a paracrine action on neuronal migration.
Document type :
Journal articles
Complete list of metadatas

Cited literature [52 references]  Display  Hide  Download

https://www.hal.inserm.fr/inserm-00484364
Contributor : Roman Tyzio <>
Submitted on : Tuesday, May 18, 2010 - 1:32:43 PM
Last modification on : Tuesday, November 10, 2020 - 3:09:42 AM
Long-term archiving on: : Thursday, September 16, 2010 - 3:11:07 PM

File

ManentJNeurosci2005.pdf
Publisher files allowed on an open archive

Identifiers

Collections

Citation

Jean-Bernard Manent, Michaël Demarque, Isabel Jorquera, Christophe Pellegrino, Yehezkel Ben-Ari, et al.. A noncanonical release of GABA and glutamate modulates neuronal migration.. Journal of Neuroscience, Society for Neuroscience, 2005, 25 (19), pp.4755-65. ⟨10.1523/JNEUROSCI.0553-05.2005⟩. ⟨inserm-00484364⟩

Share

Metrics

Record views

440

Files downloads

1836