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Evidence for anti-tumour effect of allogeneic haematopoietic SCT in cases without sustained donor engraftment.

Abstract : Remissions of haematological malignancies have been reported after allo-SCT, despite donor cell rejection, suggesting that sustained allogeneic engraftment is not mandatory to obtain a lasting anti-tumour effect. To evaluate the potential benefit from transient post-allo-SCT alloreactivity, we took advantage of the Société Française de Greffe de Moëlle et Thérapie Cellulaire (SFGM-TC) registry to colligate 14 patients with an efficient and long-lasting allogeneic (GVL) effect after allo-SCT for haematological malignancies, despite transient or absent engraftment. None received a second allogeneic graft after autologous recovery. The median duration of remission after autologous reconstitution was 118 (12-252) months. Although we cannot exclude the possibility that some patients were cured before allo-SCT, this retrospective analysis does strongly suggest that an efficient GVL effect can be observed without sustained donor engraftment, and that the transient presence of donor T cells might be sufficient to induce a powerful GVL effect.
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https://www.hal.inserm.fr/inserm-00484316
Contributor : Philippe Saas <>
Submitted on : Tuesday, May 18, 2010 - 12:03:45 PM
Last modification on : Wednesday, September 16, 2020 - 10:43:29 AM

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E. Daguindau, B. Lioure, A. Buzyn, M. Robin, C. Faucher, et al.. Evidence for anti-tumour effect of allogeneic haematopoietic SCT in cases without sustained donor engraftment.. Bone Marrow Transplantation, Nature Publishing Group, 2010, 45 (1), pp.177-80. ⟨10.1038/bmt.2009.96⟩. ⟨inserm-00484316⟩

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