Evidence for anti-tumour effect of allogeneic haematopoietic SCT in cases without sustained donor engraftment.

E. Daguindau 1, 2 B. Lioure 3 A. Buzyn 4 M. Robin 5 C. Faucher 6 Mathieu Kuentz 7 Pierre Tiberghien 1, 2 Eric Deconinck 1, 2
1 Service d'hématologie
2 HOTE GREFFON - Interactions hôte-greffon-tumeur, ingénierie cellulaire et génique - UFC (UMR INSERM 1098)
3 Département d'Oncologie et Hématologie [Strasbourg]
4 Service d'immuno-hématologie pédiatrique [CHU Necker]
5 Service greffe de moelle osseuse
6 Unité de Transplantation et de Thérapie Cellulaire
7 Service d'hématologie clinique
Abstract : Remissions of haematological malignancies have been reported after allo-SCT, despite donor cell rejection, suggesting that sustained allogeneic engraftment is not mandatory to obtain a lasting anti-tumour effect. To evaluate the potential benefit from transient post-allo-SCT alloreactivity, we took advantage of the Société Française de Greffe de Moëlle et Thérapie Cellulaire (SFGM-TC) registry to colligate 14 patients with an efficient and long-lasting allogeneic (GVL) effect after allo-SCT for haematological malignancies, despite transient or absent engraftment. None received a second allogeneic graft after autologous recovery. The median duration of remission after autologous reconstitution was 118 (12-252) months. Although we cannot exclude the possibility that some patients were cured before allo-SCT, this retrospective analysis does strongly suggest that an efficient GVL effect can be observed without sustained donor engraftment, and that the transient presence of donor T cells might be sufficient to induce a powerful GVL effect.
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Bone Marrow Transplantation, Nature Publishing Group, 2010, 45 (1), pp.177-80. 〈10.1038/bmt.2009.96〉
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Contributeur : Philippe Saas <>
Soumis le : mardi 18 mai 2010 - 12:03:45
Dernière modification le : mercredi 29 août 2018 - 01:10:29

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UNIV-FCOMTE | UMR645 | UNIV-PARIS5 | UPEC | UPEC-UPEM | USPC

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E. Daguindau, B. Lioure, A. Buzyn, M. Robin, C. Faucher, et al.. Evidence for anti-tumour effect of allogeneic haematopoietic SCT in cases without sustained donor engraftment.. Bone Marrow Transplantation, Nature Publishing Group, 2010, 45 (1), pp.177-80. 〈10.1038/bmt.2009.96〉. 〈inserm-00484316〉

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