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Misleading de novo detection of serum anti-HLA-A3 antibodies in kidney recipients having received ATG before transplantation.

Abstract : Anti-HLA antibody (Ab) monitoring is essential for the follow-up of transplant patients. However, it can be affected by drugs, especially Ab infused as a conditioning regimen for transplantation. ATG Fresenius, commonly used in this setting, is a polyclonal rabbit Ab raised against the Jurkat human T cell line (HLA-A3, 32; B7, 35). We report here the de novo detection by CDC and flow cytometry (Luminex) of anti-HLA-A3 Ab in the serum of kidney recipients treated with ATG Fresenius. The Ab, of rabbit origin, was detected in every assessable patient (n = 16), with the exception of the HLA-A3 recipients and/or recipients receiving an HLA-A3 graft, before becoming undetectable, at latest, at day 102 after transplantation. It is of major importance that transplantation monitoring laboratories bear in mind the possibility of therapeutic Ab detection when interpreting anti-HLA Ab results.
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https://www.hal.inserm.fr/inserm-00484267
Contributor : Philippe Saas <>
Submitted on : Tuesday, May 18, 2010 - 11:22:45 AM
Last modification on : Tuesday, October 27, 2020 - 2:35:50 PM

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Emeline Masson, Nadège Devillard, Jacqueline Chabod, Maria Yannaraki, Chantal Thevenin, et al.. Misleading de novo detection of serum anti-HLA-A3 antibodies in kidney recipients having received ATG before transplantation.. Human Immunology, Elsevier, 2010, 71 (2), pp.170-5. ⟨10.1016/j.humimm.2009.11.003⟩. ⟨inserm-00484267⟩

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