L. Acsady, A. Kamondi, A. Sik, T. Freund, and G. Buzsaki, GABAergic cells are the major postsynaptic targets of mossy fibers in the rat hippocampus, J Neurosci, vol.18, pp.3386-3403, 1998.

N. Afsar, D. Kaya, S. Aktan, and C. Sykut-bingol, Stroke and status epilepticus: stroke type, type of status epilepticus, and prognosis, Seizure, vol.12, issue.1, pp.23-27, 2003.
DOI : 10.1016/S1059131102001437

D. Arabadzisz and T. Freund, Changes in excitatory and inhibitory circuits of the rat hippocampus 12???14 months after complete forebrain ischemia, Neuroscience, vol.92, issue.1, pp.27-45, 1999.
DOI : 10.1016/S0306-4522(98)00736-2

P. Ascher and L. Nowak, The role of divalent cations in the N-methyl-D-aspartate responses of mouse central neurones in culture., The Journal of Physiology, vol.399, issue.1, pp.247-266, 1988.
DOI : 10.1113/jphysiol.1988.sp017078

M. Bartos, I. Vida, M. Frotscher, A. Meyer, H. Monyer et al., Fast synaptic inhibition promotes synchronized gamma oscillations in hippocampal interneuron networks, Proceedings of the National Academy of Sciences, vol.99, issue.20, pp.13222-13227, 2002.
DOI : 10.1073/pnas.192233099

C. Bladin, A. Alexandrov, A. Bellavance, N. Bornstein, B. Chambers et al., Seizures After Stroke, Archives of Neurology, vol.57, issue.11, pp.1617-1622, 2000.
DOI : 10.1001/archneur.57.11.1617

A. Bragin, E. Jr, J. Wilson, C. Fried, I. Mathern et al., Hippocampal and Entorhinal Cortex High-Frequency Oscillations (100-500 Hz) in Human Epileptic Brain and in Kainic Acid-Treated Rats with Chronic Seizures, Epilepsia, vol.37, issue.2, pp.127-137, 1999.
DOI : 10.1016/0920-1211(89)90030-2

A. Bragin, I. Mody, C. Wilson, E. Jr, and J. , Local generation of fast ripples in epileptic brain, J Neurosci, vol.22, pp.2012-2021, 2002.

A. Bragin, C. Wilson, J. Almajano, I. Mody, E. Jr et al., High-frequency Oscillations after Status Epilepticus: Epileptogenesis and Seizure Genesis, Epilepsia, vol.19, issue.9, pp.1017-1023, 2004.
DOI : 10.1002/ana.10291

J. Brierley and J. Cooper, CEREBRAL COMPLICATIONS OF HYPOTENSIVE ANAESTHESIA IN A HEALTHY ADULT, Journal of Neurology, Neurosurgery & Psychiatry, vol.25, issue.1, pp.24-30, 1962.
DOI : 10.1136/jnnp.25.1.24

A. Brooks-kayal, M. Shumate, H. Jin, T. Rikhter, and D. Coulter, Selective changes in single cell GABAA receptor subunit expression and function in temporal lobe epilepsy, Nature Medicine, vol.70, issue.10, pp.1166-1172, 1998.
DOI : 10.1016/0306-4522(95)00348-M

P. Buckmaster and F. Dudek, In vivo intracellular analysis of granule cell axon reorganization in epileptic rats, J Neurophysiol, vol.81, pp.712-721, 1999.

P. Buckmaster and A. Jongen-relo, Highly specific neuron loss preserves lateral inhibitory circuits in the dentate gyrus of kainate-induced epileptic rats, J Neurosci, vol.19, pp.9519-9529, 1999.

G. Buzsaki, Z. Horvath, R. Urioste, J. Hetke, and K. Wise, High-frequency network oscillation in the hippocampus, Science, vol.256, issue.5059, pp.1025-1027, 1992.
DOI : 10.1126/science.1589772

M. Calcagnotto, M. Paredes, T. Tihan, N. Barbaro, and S. Baraban, Dysfunction of Synaptic Inhibition in Epilepsy Associated with Focal Cortical Dysplasia, Journal of Neuroscience, vol.25, issue.42, pp.9649-9657, 2005.
DOI : 10.1523/JNEUROSCI.2687-05.2005

P. Castillo, R. Malenka, and R. Nicoll, Kainate receptors mediate a slow postsynaptic current in hippocampal CA3 neurons, Nature, vol.388, pp.182-186, 1997.

F. Chaudhry, R. Reimer, E. Bellocchio, N. Danbolt, K. Osen et al., The vesicular GABA transporter, VGAT, localizes to synaptic vesicles in sets of glycinergic as well as GABAergic neurons, J Neurosci, vol.18, pp.9733-9750, 1998.

S. Cobb, E. Buhl, K. Halasy, O. Paulsen, and P. Somogyi, Synchronization of neuronal activity in hippocampus by individual GABAergic interneurons, Nature, vol.378, issue.6552, pp.75-78, 1995.
DOI : 10.1038/378075a0

L. Cocito, E. Favale, and L. Reni, Epileptic seizures in cerebral arterial occlusive disease, Stroke, vol.13, issue.2, pp.189-195, 1982.
DOI : 10.1161/01.STR.13.2.189

P. Congar, J. Gaiarsa, T. Popovici, B. Ari, Y. Crépel et al., Permanent reduction of seizure threshold in post-ischemic CA3 pyramidal neurons, J Neurophysiol, vol.83, pp.2040-2046, 2000.
URL : https://hal.archives-ouvertes.fr/inserm-00485226

R. Cossart, C. Dinocourt, J. Hirsch, A. Merchan-perez, D. Felipe et al., Dendritic but not somatic GABAergic inhibition is decreased in experimental epilepsy, Nat Neurosci, vol.4, pp.52-62, 2001.
URL : https://hal.archives-ouvertes.fr/inserm-00484880

R. Cossart, J. Epsztein, R. Tyzio, H. Becq, J. Hirsch et al., Quantal Release of Glutamate Generates Pure Kainate and Mixed AMPA/Kainate EPSCs in Hippocampal Neurons, Neuron, vol.35, issue.1, pp.147-159, 2002.
DOI : 10.1016/S0896-6273(02)00753-5
URL : https://hal.archives-ouvertes.fr/inserm-00484870

R. Cossart, C. Bernard, B. Ari, and Y. , Multiple facets of GABAergic neurons and synapses: multiple fates of GABA signalling in epilepsies, Trends in Neurosciences, vol.28, issue.2, pp.108-115, 2005.
DOI : 10.1016/j.tins.2004.11.011
URL : https://hal.archives-ouvertes.fr/inserm-00484541

V. Crépel, A. Represa, M. Beaudoin, and Y. Ben-ari, Hippocampal damage induced by ischemia and intra-amygdaloid kainate injection: Effects on N-methyl-d-aspartate, N-(1-[2-thienyl]cyclohexyl)piperidine and glycine binding sites, Neuroscience, vol.31, issue.3, pp.605-612, 1989.
DOI : 10.1016/0306-4522(89)90426-0

V. Crépel, J. Epsztein, B. Ari, and Y. , Ischemia induces short- and long-term remodeling of synaptic activity in the hippocampus, Journal of Cellular and Molecular Medicine, vol.83, issue.4, pp.401-407, 2003.
DOI : 10.1007/BF00716267

J. Csicsvari, B. Jamieson, K. Wise, and G. Buzsaki, Mechanisms of Gamma Oscillations in the Hippocampus of the Behaving Rat, Neuron, vol.37, issue.2, pp.311-322, 2003.
DOI : 10.1016/S0896-6273(02)01169-8

C. Dinocourt, Z. Petanjek, T. Freund, B. Ari, Y. Esclapez et al., Loss of interneurons innervating pyramidal cell dendrites and axon initial segments in the CA1 region of the hippocampus following pilocarpine-induced seizures, The Journal of Comparative Neurology, vol.459, issue.4, pp.407-425, 2003.
DOI : 10.1002/cne.10622
URL : https://hal.archives-ouvertes.fr/inserm-00484796

A. Draguhn, R. Traub, D. Schmitz, and J. Jefferys, Electrical coupling underlies high-frequency oscillations in the hippocampus in vitro, Nature, vol.391, issue.6689, pp.189-192, 1998.
DOI : 10.1038/28184

V. Dzhala and K. Staley, Transition from interictal to ictal activity in limbic networks in vitro, J Neurosci, vol.23, pp.7873-7880, 2003.

V. Dzhala and K. Staley, Mechanisms of Fast Ripples in the Hippocampus, Journal of Neuroscience, vol.24, issue.40, pp.8896-8906, 2004.
DOI : 10.1523/JNEUROSCI.3112-04.2004

J. Epsztein, A. Represa, I. Jorquera, B. Ari, Y. Crépel et al., Recurrent Mossy Fibers Establish Aberrant Kainate Receptor-Operated Synapses on Granule Cells from Epileptic Rats, Journal of Neuroscience, vol.25, issue.36, pp.8229-8239, 2005.
DOI : 10.1523/JNEUROSCI.1469-05.2005
URL : https://hal.archives-ouvertes.fr/inserm-00484549

M. Esclapez, J. Hirsch, B. Ari, Y. Bernard, and C. , Newly formed excitatory pathways provide a substrate for hyperexcitability in experimental temporal lobe epilepsy, The Journal of Comparative Neurology, vol.851, issue.4, pp.449-460, 1999.
DOI : 10.1002/(SICI)1096-9861(19990614)408:4<449::AID-CNE1>3.0.CO;2-R

A. Fisahn, F. Pike, E. Buhl, and O. Paulsen, Cholinergic induction of network oscillations at 40???Hz in the hippocampus in vitro, Nature, vol.243, issue.6689, pp.186-189, 1998.
DOI : 10.1038/28179

T. Freund, Interneuron Diversity series: Rhythm and mood in perisomatic inhibition, Trends in Neurosciences, vol.26, issue.9, pp.489-495, 2003.
DOI : 10.1016/S0166-2236(03)00227-3

T. Freund and G. Buzsaki, Interneurons of the hippocampus, Hippocampus, vol.495, issue.1, pp.347-470, 1996.
DOI : 10.1002/(SICI)1098-1063(1996)6:4<347::AID-HIPO1>3.0.CO;2-I
URL : https://hal.archives-ouvertes.fr/inserm-00484796

T. Freund and Z. Magloczky, Early degeneration of calretinin-containing neurons in the rat hippocampus after ischemia, Neuroscience, vol.56, issue.3, pp.581-596, 1993.
DOI : 10.1016/0306-4522(93)90358-M

T. Freund, G. Buzsaki, A. Leon, K. Baimbridge, and P. Somogyi, Relationship of neuronal vulnerability and calcium binding protein immunoreactivity in ischemia, Experimental Brain Research, vol.83, issue.1, pp.55-66, 1991.
DOI : 10.1007/BF00232193

J. Fritschy and I. Brunig, Formation and plasticity of GABAergic synapses: physiological mechanisms and pathophysiological implications, Pharmacology & Therapeutics, vol.98, issue.3, pp.299-323, 2003.
DOI : 10.1016/S0163-7258(03)00037-8

M. Ginsberg and R. Busto, Rodent models of cerebral ischemia, Stroke, vol.20, issue.12, pp.1627-1642, 1989.
DOI : 10.1161/01.STR.20.12.1627

P. Gloor, ABSTRACT:, Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, vol.2, issue.S4, pp.554-558, 1991.
DOI : 10.1007/978-3-642-71103-9_9

P. Goldstein, F. Elsen, S. Ying, C. Ferguson, G. Homanics et al., Prolongation of Hippocampal Miniature Inhibitory Postsynaptic Currents in Mice Lacking the GABAA Receptor alpha 1 Subunit, Journal of Neurophysiology, vol.88, issue.6, pp.3208-3217, 2002.
DOI : 10.1152/jn.00885.2001

A. Gulyas, N. Hajos, and T. Freund, Interneurons containing calretinin are specialized to control other interneurons in the rat hippocampus, J Neurosci, vol.16, pp.3397-3411, 1996.

N. Hajos, J. Palhalmi, E. Mann, B. Nemeth, O. Paulsen et al., Spike Timing of Distinct Types of GABAergic Interneuron during Hippocampal Gamma Oscillations In Vitro, Journal of Neuroscience, vol.24, issue.41, pp.9127-9137, 2004.
DOI : 10.1523/JNEUROSCI.2113-04.2004

S. Hefft and J. P. , Asynchronous GABA release generates long-lasting inhibition at a hippocampal interneuron???principal neuron synapse, Nature Neuroscience, vol.488, issue.10, pp.1319-1328, 2005.
DOI : 10.1073/pnas.0304752101

J. Hirsch, C. Agassandian, A. Merchan-perez, B. Ari, Y. Defelipe et al., Deficit of quantal release of GABA in experimental models of temporal lobe epilepsy, Nat Neurosci, vol.2, pp.499-500, 1999.
URL : https://hal.archives-ouvertes.fr/inserm-00486214

M. Hsu and G. Buzsaki, Vulnerability of mossy fiber targets in the rat hippocampus to forebrain ischemia, J Neurosci, vol.13, pp.3964-3979, 1993.

M. Kobayashi and P. Buckmaster, Reduced inhibition of dentate granule cells in a model of temporal lobe epilepsy, J Neurosci, vol.23, pp.2440-2452, 2003.

J. Leite, T. Babb, J. Pretorius, P. Kuhlman, K. Yeoman et al., Neuron loss, mossy fiber sprouting, and interictal spikes after intrahippocampal kainate in developing rats, Epilepsy Research, vol.26, issue.1, pp.219-231, 1996.
DOI : 10.1016/S0920-1211(96)00055-1

M. Lossius, O. Ronning, G. Slapo, P. Mowinckel, and L. Gjerstad, Poststroke Epilepsy: Occurrence and Predictors-A Long-term Prospective Controlled Study (Akershus Stroke Study), Epilepsia, vol.33, issue.8, pp.1246-1251, 2005.
DOI : 10.1111/j.1600-0404.2004.00273.x

S. Mcintire, R. Reimer, K. Schuske, R. Edwards, and E. Jorgensen, Identification and characterization of the vesicular GABA transporter, Nature, vol.389, pp.870-876, 1997.

J. Mcnamara, Human hypoxia and seizures: effects and interactions, Adv Neurol, vol.26, pp.137-143, 1979.

. Menendez-dlp, G. Huberfeld, I. Cohen, and R. Miles, Threshold Behavior in the Initiation of Hippocampal Population Bursts, Neuron, vol.49, issue.1, pp.131-142, 2006.
DOI : 10.1016/j.neuron.2005.10.034

R. Miles and R. Wong, Inhibitory control of local excitatory circuits in the guinea-pig hippocampus., The Journal of Physiology, vol.388, issue.1, pp.611-629, 1987.
DOI : 10.1113/jphysiol.1987.sp016634

T. Mittmann, M. Qu, K. Zilles, and H. Luhmann, Long-term cellular dysfunction after focal cerebral ischemia: in vitro analyses, Neuroscience, vol.85, issue.1, pp.15-27, 1998.
DOI : 10.1016/S0306-4522(97)00638-6

L. Mudrick and K. Baimbridge, Long-term structural changes in the rat hippocampal formation following cerebral ischemia, Brain Research, vol.493, issue.1, pp.179-184, 1989.
DOI : 10.1016/0006-8993(89)91014-7

. Epsztein, ? Morpho-Functional Study of Post-Ischemic CA3 Area, J. Neurosci, issue.26, pp.7082-7092, 2006.

M. Okazaki, D. Evenson, and J. Nadler, Hippocampal mossy fiber sprouting and synapse formation after status epilepticus in rats: Visualization after retrograde transport of biocytin, The Journal of Comparative Neurology, vol.76, issue.4, pp.515-534, 1995.
DOI : 10.1002/cne.903520404

T. Pedley, Interictal epileptiform discharges: discriminating characteristics and clinical correlations, Am J EEG Technol, vol.20, pp.101-119, 1980.

W. Pulsinelli, Selective Neuronal Vulnerability: Morphological and Molecular Characteristics, Prog Brain Res, vol.63, pp.29-37, 1985.
DOI : 10.1016/S0079-6123(08)61973-1

W. Pulsinelli and J. Brierley, A new model of bilateral hemispheric ischemia in the unanesthetized rat, Stroke, vol.10, issue.3, pp.267-272, 1979.
DOI : 10.1161/01.STR.10.3.267

A. Represa, E. Tremblay, and Y. Ben-ari, Kainate binding sites in the hippocampal mossy fibers: Localization and plasticity, Neuroscience, vol.20, issue.3, pp.739-748, 1987.
DOI : 10.1016/0306-4522(87)90237-5

A. Represa, V. Crépel, and B. Ari, Transient cerebral ischemia induces changes in SRIF mRNA in the fascia dentata, Molecular Brain Research, vol.10, issue.4, pp.337-342, 1991.
DOI : 10.1016/0169-328X(91)90092-C

V. Salanova, O. Markand, and R. Worth, Longitudinal Follow-Up in 145 Patients with Medically Refractory Temporal Lobe Epilepsy Treated Surgically Between 1984 and 1995, Epilepsia, vol.51, issue.10, pp.1417-1423, 1984.
DOI : 10.1002/ana.410320613

R. Schmidt-kastner and T. Freund, Selective vulnerability of the hippocampus in brain ischemia, Neuroscience, vol.40, issue.3, pp.599-636, 1991.
DOI : 10.1016/0306-4522(91)90001-5

L. Shao and F. Dudek, Changes in mIPSCs and sIPSCs After Kainate Treatment: Evidence for Loss of Inhibitory Input to Dentate Granule Cells and Possible Compensatory Responses, Journal of Neurophysiology, vol.94, issue.2, pp.952-960, 2005.
DOI : 10.1152/jn.01342.2004

B. Siesjo, Cell Damage in the Brain: A Speculative Synthesis, Journal of Cerebral Blood Flow & Metabolism, vol.328, issue.2, pp.155-185, 1981.
DOI : 10.1126/science.175.4023.720

A. Sik, N. Tamamaki, and T. Freund, Complete Axon Arborization of a Single CA3 Pyramidal Cell in the Rat Hippocampus, and its Relationship With Postsynaptic Parvalbumin-containing Interneurons, European Journal of Neuroscience, vol.280, issue.12, pp.1719-1728, 1993.
DOI : 10.1111/j.1460-9568.1993.tb00239.x

I. Silverman, L. Restrepo, and G. Mathews, Poststroke Seizures, Archives of Neurology, vol.59, issue.2, pp.195-201, 2002.
DOI : 10.1001/archneur.59.2.195

P. Somogyi and T. Klausberger, Defined types of cortical interneurone structure space and spike timing in the hippocampus, The Journal of Physiology, vol.441, issue.1, pp.9-26, 2005.
DOI : 10.1113/jphysiol.2004.078915

J. Somogyi, A. Baude, Y. Omori, H. Shimizu, E. Mestikawy et al., GABAergic basket cells expressing cholecystokinin contain vesicular glutamate transporter type 3 (VGLUT3) in their synaptic terminals in hippocampus and isocortex of the rat, European Journal of Neuroscience, vol.238, issue.3, pp.552-569, 2004.
DOI : 10.1016/S0169-328X(96)00209-4

K. Staley, J. Hellier, and F. Dudek, Do Interictal Spikes Drive Epileptogenesis?, The Neuroscientist, vol.85, issue.3, pp.272-276, 2005.
DOI : 10.1177/1073858405278239

M. Sundaram, R. Sadler, G. Young, and N. Pillay, EEG in Epilepsy: Current Perspectives, Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques, vol.12, issue.04, pp.255-262, 1999.
DOI : 10.1016/0013-4694(91)90013-T

T. Sutula, X. He, J. Cavazos, and G. Scott, Synaptic reorganization in the hippocampus induced by abnormal functional activity, Science, vol.239, issue.4844, pp.1147-1150, 1988.
DOI : 10.1126/science.2449733

R. Wennberg, F. Quesney, A. Olivier, and T. Rasmussen, Electrocorticography and outcome in frontal lobe epilepsy, Electroencephalography and Clinical Neurophysiology, vol.106, issue.4, pp.357-368, 1998.
DOI : 10.1016/S0013-4694(97)00148-X

J. Wuarin and F. Dudek, Excitatory synaptic input to granule cells increases with time after kainate treatment, J Neurophysiol, vol.85, pp.1067-1077, 2001.

S. Zola-morgan, L. Squire, and D. Amaral, Human amnesia and the medial temporal region: enduring memory impairment following a bilateral lesion limited to field CA1 of the hippocampus, Neurocase, vol.2, issue.4, pp.2950-2967, 1986.
DOI : 10.1093/neucas/2.4.259-aw