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Network mechanisms of spindle-burst oscillations in the neonatal rat barrel cortex in vivo.

Abstract : Early in development, cortical networks generate particular patterns of activity that participate in cortical development. The dominant pattern of electrical activity in the neonatal rat neocortex in vivo is a spatially confined spindle-burst. Here, we studied network mechanisms of generation of spindle-bursts in the barrel cortex of neonatal rats using a superfused cortex preparation in vivo. Both spontaneous and sensory-evoked spindle-bursts were present in the superfused barrel cortex. Pharmacological analysis revealed that spindle-bursts are driven by glutamatergic synapses with a major contribution of AMPA/kainate receptors, but slight participation of NMDA receptors and gap junctions. Although GABAergic synapses contributed minimally to the pacing the rhythm of spindle-burst oscillations, surround GABAergic inhibition appeared to be crucial for their compartmentalization. We propose that local spindle-burst oscillations, driven by glutamatergic synapses and spatially confined by GABAergic synapses, contribute to the development of barrel cortex during the critical period of developmental plasticity.
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Marat Minlebaev, Yehezkel Ben-Ari, Rustem Khazipov. Network mechanisms of spindle-burst oscillations in the neonatal rat barrel cortex in vivo.. Journal of Neurophysiology, American Physiological Society, 2007, 97 (1), pp.692-700. ⟨10.1152/jn.00759.2006⟩. ⟨inserm-00483860⟩

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