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Journal articles
Network mechanisms of spindle-burst oscillations in the neonatal rat barrel cortex in vivo.
Abstract : Early in development, cortical networks generate particular patterns of activity that participate in cortical development. The dominant pattern of electrical activity in the neonatal rat neocortex in vivo is a spatially confined spindle-burst. Here, we studied network mechanisms of generation of spindle-bursts in the barrel cortex of neonatal rats using a superfused cortex preparation in vivo. Both spontaneous and sensory-evoked spindle-bursts were present in the superfused barrel cortex. Pharmacological analysis revealed that spindle-bursts are driven by glutamatergic synapses with a major contribution of AMPA/kainate receptors, but slight participation of NMDA receptors and gap junctions. Although GABAergic synapses contributed minimally to the pacing the rhythm of spindle-burst oscillations, surround GABAergic inhibition appeared to be crucial for their compartmentalization. We propose that local spindle-burst oscillations, driven by glutamatergic synapses and spatially confined by GABAergic synapses, contribute to the development of barrel cortex during the critical period of developmental plasticity.
Cited literature [35 references]
https://www.hal.inserm.fr/inserm-00483860
Contributor : Roman Tyzio <>
Submitted on : Monday, May 17, 2010 - 1:39:05 PM
Last modification on : Thursday, March 5, 2020 - 6:59:40 PM
Long-term archiving on: : Thursday, December 1, 2016 - 12:42:14 AM
Contributor : Roman Tyzio <>
Submitted on : Monday, May 17, 2010 - 1:39:05 PM
Last modification on : Thursday, March 5, 2020 - 6:59:40 PM
Long-term archiving on: : Thursday, December 1, 2016 - 12:42:14 AM
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MinlebaevJNeurophysiol2007.pdf
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