Skip to Main content Skip to Navigation
Journal articles

A parturition-associated nonsynaptic coherent activity pattern in the developing hippocampus.

Abstract : Correlated neuronal activity is instrumental in the formation of networks, but its emergence during maturation is poorly understood. We have used multibeam two-photon calcium microscopy combined with targeted electrophysiological recordings in order to determine the development of population coherence from embryonic to postnatal stages in the hippocampus. At embryonic stages (E16-E19), synchronized activity is absent, and neurons are intrinsically active and generate L-type channel-mediated calcium spikes. At birth, small cell assemblies coupled by gap junctions spontaneously generate synchronous nonsynaptic calcium plateaus associated to recurrent burst discharges. The emergence of coherent calcium plateaus at birth is controlled by oxytocin, a maternal hormone initiating labour, and progressively shut down a few days later by the synapse-driven giant depolarizing potentials (GDPs) that synchronize the entire network. Therefore, in the developing hippocampus, delivery is an important signal that triggers the first coherent activity pattern, which is silenced by the emergence of synaptic transmission.
Document type :
Journal articles
Complete list of metadata

Cited literature [69 references]  Display  Hide  Download
Contributor : Roman Tyzio Connect in order to contact the contributor
Submitted on : Friday, May 14, 2010 - 2:10:42 PM
Last modification on : Wednesday, October 6, 2021 - 2:44:02 PM
Long-term archiving on: : Wednesday, November 30, 2016 - 11:56:31 PM


 Restricted access
To satisfy the distribution rights of the publisher, the document is embargoed until : jamais

Please log in to resquest access to the document




Valérie Crépel, Dmitriy Aronov, Isabel Jorquera, Alfonso Represa, Yehezkel Ben-Ari, et al.. A parturition-associated nonsynaptic coherent activity pattern in the developing hippocampus.. Neuron, Elsevier, 2007, 54 (1), pp.105-20. ⟨10.1016/j.neuron.2007.03.007⟩. ⟨inserm-00483533⟩



Record views