Inhibition of glutamate transporters results in a "suppression-burst" pattern and partial seizures in the newborn rat.

Abstract : PURPOSE: To determine the electrophysiological pattern and propose a clinical relevance of a deficient glutamate transport in the developing brain. METHODS: (a) Surface EEG-video monitoring in freely moving pups; (b) intracortical multiple unit activity (MUA) and local field potential recordings in 5- to 7-day-old rats after pharmacological inhibition of the glutamate transporters by DL-TBOA. RESULTS: Glutamate transporters inhibition alters the background cortical electrical activity inducing a dominant and persistent pattern of bilateral recurrent paroxysmal bursts alternating with periods of hypoactivity and also partial seizures. Intracortical local field recordings show that paroxysmal bursts are associated with multiunits and gamma oscillations separated by periods of silence. This cortical activity involves the activation of ionotropic glutamate receptors and was not observed after kainate and pilocarpine administration. CONCLUSIONS: We show that a dysfunction of glutamate transporters in immature rats leads to a singular cortical activity that is reminiscent of a "suppression-burst" pattern. We propose that an early deficiency of glutamate transport may underlie some early onset epilepsies.
Type de document :
Article dans une revue
Epilepsia, Wiley, 2007, 48 (1), pp.169-74. 〈10.1111/j.1528-1167.2006.00839.x〉
Liste complète des métadonnées

Littérature citée [27 références]  Voir  Masquer  Télécharger

http://www.hal.inserm.fr/inserm-00483529
Contributeur : Roman Tyzio <>
Soumis le : vendredi 14 mai 2010 - 14:06:08
Dernière modification le : mardi 28 août 2018 - 01:08:57
Document(s) archivé(s) le : jeudi 1 décembre 2016 - 01:44:16

Fichier

 Accès restreint
Fichier visible le : jamais

Connectez-vous pour demander l'accès au fichier

Identifiants

Collections

Citation

Mathieu Milh, Hélène Becq, Nathalie Villeneuve, Yehezkel Ben-Ari, Laurent Aniksztejn. Inhibition of glutamate transporters results in a "suppression-burst" pattern and partial seizures in the newborn rat.. Epilepsia, Wiley, 2007, 48 (1), pp.169-74. 〈10.1111/j.1528-1167.2006.00839.x〉. 〈inserm-00483529〉

Partager

Métriques

Consultations de la notice

65