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Journal articles
Late-onset epileptogenesis and seizure genesis: lessons from models of cerebral ischemia.
Abstract : Patients surviving ischemic stroke often express delayed epileptic syndromes. Late poststroke seizures occur after a latency period lasting from several months to years after the insult. These seizures might result from ischemia-induced neuronal death and associated morphological and physiological changes that are only partly elucidated. This review summarizes the long-term morphofunctional alterations observed in animal models of both focal and global ischemia that could explain late-onset seizures and epileptogenesis. In particular, this review emphasizes the change in GABAergic and glutamatergic signaling leading to hyperexcitability and seizure genesis.
Cited literature [173 references]
https://www.hal.inserm.fr/inserm-00483497
Contributor : Roman Tyzio <>
Submitted on : Friday, May 14, 2010 - 1:30:30 PM
Last modification on : Tuesday, November 10, 2020 - 3:09:47 AM
Long-term archiving on: : Wednesday, November 30, 2016 - 10:01:48 PM
Contributor : Roman Tyzio <>
Submitted on : Friday, May 14, 2010 - 1:30:30 PM
Last modification on : Tuesday, November 10, 2020 - 3:09:47 AM
Long-term archiving on: : Wednesday, November 30, 2016 - 10:01:48 PM