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Late-onset epileptogenesis and seizure genesis: lessons from models of cerebral ischemia.

Abstract : Patients surviving ischemic stroke often express delayed epileptic syndromes. Late poststroke seizures occur after a latency period lasting from several months to years after the insult. These seizures might result from ischemia-induced neuronal death and associated morphological and physiological changes that are only partly elucidated. This review summarizes the long-term morphofunctional alterations observed in animal models of both focal and global ischemia that could explain late-onset seizures and epileptogenesis. In particular, this review emphasizes the change in GABAergic and glutamatergic signaling leading to hyperexcitability and seizure genesis.
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https://www.hal.inserm.fr/inserm-00483497
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Submitted on : Friday, May 14, 2010 - 1:30:30 PM
Last modification on : Tuesday, February 4, 2020 - 10:00:04 AM
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Jérôme Epsztein, Yehezkel Ben-Ari, Alfonso Represa, Valérie Crépel. Late-onset epileptogenesis and seizure genesis: lessons from models of cerebral ischemia.. Neuroscientist, SAGE Publications, 2008, 14 (1), pp.78-90. ⟨10.1177/1073858407301681⟩. ⟨inserm-00483497⟩

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