Skip to Main content Skip to Navigation
Journal articles

Clinical, biometric and structural evaluation of the long-term effects of a topical treatment with ascorbic acid and madecassoside in photoaged human skin.

Abstract : Skin ageing is a complex process determined by the genetic endowment of individual and environmental factors, such as sun exposure. The effects of skin ageing are mostly encountered in the superficial dermis and in the epidermis. We have previously demonstrated in vivo the beneficial effect of a topically applied formula of 5% vitamin C in the treatment of skin ageing. Another active compound, madecassoside extracted from Centella asiatica, known to induce collagen expression and/or to modulate inflammatory mediators, might thus prevent and correct some signs of ageing. A randomized double-blind study was carried out on photoaged skin of 20 female volunteers to investigate the effects of topically applied 5% vitamin C and 0.1% madecassoside on the clinical, biophysical and structural skin properties. After 6 months of treatment, we observed a significant improvement of the clinical score for deep and superficial wrinkles, suppleness, firmness, roughness and skin hydration. These results were corroborated by measurements of skin elasticity and semi-quantitative histological assessment of the elastic fibre network in the papillary dermis. Two-thirds of the subjects showed an improvement. The re-appearance of a normally structured elastic fibre network was observed. Our results revealed a functional and structural remodelling of chronically sun-damaged skin.
Document type :
Journal articles
Complete list of metadatas

https://www.hal.inserm.fr/inserm-00483431
Contributor : Philippe Saas <>
Submitted on : Friday, May 14, 2010 - 11:50:52 AM
Last modification on : Wednesday, September 16, 2020 - 10:43:29 AM

Links full text

Identifiers

Collections

Citation

Marek Haftek, Sophie Mac-Mary, Marie-Aude Le Bitoux, Pierre Creidi, Sophie Seité, et al.. Clinical, biometric and structural evaluation of the long-term effects of a topical treatment with ascorbic acid and madecassoside in photoaged human skin.. Experimental Dermatology, Wiley, 2008, 17 (11), pp.946-52. ⟨10.1111/j.1600-0625.2008.00732.x⟩. ⟨inserm-00483431⟩

Share

Metrics

Record views

198