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Ixabepilone, a novel epothilone analog in the treatment of breast cancer.

Abstract : BACKGROUND: Natural epothilones and their analogs promote tumor cell death by binding to tubulin and stabilizing microtubules, causing cell death. Ixabepilone (BMS-247550, Ixempra) is an epothilone analog that optimizes the properties naturally observed with epothilone B. OBJECTIVE: To provide an overview of the results achieved by ixabepilone in metastatic breast cancer. METHODS: A PubMed search was performed to provide an extensive review of all published data on ixabepilone, in addition to all data reported from international congresses, from 2003 to 2007. RESULTS/CONCLUSION: There is a clear need for new agents active against resistant metastatic breast cancer and ixabepilone might be a welcome new compound in this situation.
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https://www.hal.inserm.fr/inserm-00483392
Contributor : Philippe Saas <>
Submitted on : Friday, May 14, 2010 - 11:24:54 AM
Last modification on : Tuesday, October 27, 2020 - 2:35:50 PM

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Xavier Pivot, Christian Villanueva, Loïc Chaigneau, Thierry Nguyen, Martin Demarchi, et al.. Ixabepilone, a novel epothilone analog in the treatment of breast cancer.. Expert Opinion on Investigational Drugs, Taylor & Francis, 2008, 17 (4), pp.593-9. ⟨10.1517/13543784.17.4.593⟩. ⟨inserm-00483392⟩

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