GABAergic hub neurons orchestrate synchrony in developing hippocampal networks.

Paolo Bonifazi 1 Miri Goldin 1 Michel Picardo 1 Isabel Jorquera 1 A. Cattani 1 Gregory Bianconi 2 Alfonso Represa 1 Yehezkel Ben-Ari 1 Rosa Cossart 1, *
* Auteur correspondant
1 INMED - Institut de neurobiologie de la Méditerranée
2 Department of Physics
Abstract : Brain function operates through the coordinated activation of neuronal assemblies. Graph theory predicts that scale-free topologies, which include "hubs" (superconnected nodes), are an effective design to orchestrate synchronization. Whether hubs are present in neuronal assemblies and coordinate network activity remains unknown. Using network dynamics imaging, online reconstruction of functional connectivity, and targeted whole-cell recordings in rats and mice, we found that developing hippocampal networks follow a scale-free topology, and we demonstrated the existence of functional hubs. Perturbation of a single hub influenced the entire network dynamics. Morphophysiological analysis revealed that hub cells are a subpopulation of gamma-aminobutyric acid-releasing (GABAergic) interneurons possessing widespread axonal arborizations. These findings establish a central role for GABAergic interneurons in shaping developing networks and help provide a conceptual framework for studying neuronal synchrony.
Type de document :
Article dans une revue
Science, American Association for the Advancement of Science, 2009, 326 (5958), pp.1419-24. 〈10.1126/science.1175509〉
Liste complète des métadonnées

Littérature citée [30 références]  Voir  Masquer  Télécharger
http://www.hal.inserm.fr/inserm-00483216
Contributeur : Roman Tyzio <>
Soumis le : mercredi 12 mai 2010 - 18:06:25
Dernière modification le : vendredi 2 février 2018 - 01:22:35
Document(s) archivé(s) le : jeudi 1 décembre 2016 - 00:39:42

Fichier

Bonifazi_Science_2009.pdf
Fichiers produits par l'(les) auteur(s)

Identifiants

Collections

UNIV-AMU | CERCLE

Citation

Paolo Bonifazi, Miri Goldin, Michel Picardo, Isabel Jorquera, A. Cattani, et al.. GABAergic hub neurons orchestrate synchrony in developing hippocampal networks.. Science, American Association for the Advancement of Science, 2009, 326 (5958), pp.1419-24. 〈10.1126/science.1175509〉. 〈inserm-00483216〉

Exporter

BibTeX TEI DC DCterms EndNote

Partager

Métriques

Consultations de la notice

176

Téléchargements de fichiers

572

Contact

support.ccsd.cnrs.fr
hal.support@ccsd.cnrs.fr
Logo CCSD