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Activity-dependent dendritic release of BDNF and biological consequences.

Abstract : Network construction and reorganization is modulated by the level and pattern of synaptic activity generated in the nervous system. During the past decades, neurotrophins, and in particular brain-derived neurotrophic factor (BDNF), have emerged as attractive candidates for linking synaptic activity and brain plasticity. Thus, neurotrophin expression and secretion are under the control of activity-dependent mechanisms and, besides their classical role in supporting neuronal survival neurotrophins, modulate nearly all key steps of network construction from neuronal migration to experience-dependent refinement of local connections. In this paper, we provide an overview of recent findings showing that BDNF can serve as a target-derived messenger for activity-dependent synaptic plasticity and development at the single cell level.
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Submitted on : Wednesday, May 12, 2010 - 5:14:00 PM
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Nicola Kuczewski, Christophe Porcher, Volkmar Lessmann, Igor Medina, Jean-Luc Gaiarsa. Activity-dependent dendritic release of BDNF and biological consequences.. Molecular Neurobiology, Humana Press, 2009, 39 (1), pp.37-49. ⟨10.1007/s12035-009-8050-7⟩. ⟨inserm-00483180⟩



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