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Journal articles
Activity-dependent dendritic release of BDNF and biological consequences.
Abstract : Network construction and reorganization is modulated by the level and pattern of synaptic activity generated in the nervous system. During the past decades, neurotrophins, and in particular brain-derived neurotrophic factor (BDNF), have emerged as attractive candidates for linking synaptic activity and brain plasticity. Thus, neurotrophin expression and secretion are under the control of activity-dependent mechanisms and, besides their classical role in supporting neuronal survival neurotrophins, modulate nearly all key steps of network construction from neuronal migration to experience-dependent refinement of local connections. In this paper, we provide an overview of recent findings showing that BDNF can serve as a target-derived messenger for activity-dependent synaptic plasticity and development at the single cell level.
Cited literature [79 references]
https://www.hal.inserm.fr/inserm-00483180
Contributor : Roman Tyzio <>
Submitted on : Wednesday, May 12, 2010 - 5:14:00 PM
Last modification on : Tuesday, February 4, 2020 - 10:00:04 AM
Long-term archiving on: : Thursday, December 1, 2016 - 1:28:57 AM
Contributor : Roman Tyzio <>
Submitted on : Wednesday, May 12, 2010 - 5:14:00 PM
Last modification on : Tuesday, February 4, 2020 - 10:00:04 AM
Long-term archiving on: : Thursday, December 1, 2016 - 1:28:57 AM